Effects of folinic acid and fluorouracil chemotherapy on right ventricle functions as assessed with tricuspid annular plane systolic excursion

Aim: This study aimed to investigate the effects of folinic acid and fluorouracil (bolus FUFA regimen) chemotherapy on right ventricle (RV) functions. Materials and Methods: Thirty-four gastrointestinal (GI) cancer patients treated with antineoplastic drugs were included the study. All participants received FUFA chemotherapy protocol for colorectal, gastric and pancreatic cancer (i.e. fluorouracil 400-425 mg/m2 intravenous day 1-5 + folinic acid 20-25 mg/m2 intravenous day 1-5 every 28 days x6 cycles) with or without radiation therapy according to the cancer and patient status. All participants have undergone complete physical and laboratory examination and complete echocardiographic evaluation including detailed right ventricle functional evaluations before the onset of chemotherapy and 6 months after the start of treatment. Results: Mean RV thickness was 0.49 cm before chemotherapy and 0.62 cm at the end of the treatment (p=0.29). Mean tricuspid annular plane systolic excursion (TAPSE) values were 2.08 ± 0.3 and 2.00 ± 0.39 cm, respectively (p=0.25). RV total ejection isovolumic (Tei) index related to the chemotherapy did not change significantly (0.24 and 0.29, respectively, p=0.07). Also we did not find significant chance in the RV end diastolic diameter, RV end systolic diameter, vena cava diameter on inspiration and expiration. Conclusion: Bolus FUFA regimen chemotherapy does not diminish the RV functions as assessed by TAPSE and RV Tei index in GI cancer patients. © 2014, Hippokratia General Hospital of Thessaloniki. All rights reserved.

Dergi Adı Hippokratia
Dergi Cilt Bilgisi 18
Dergi Sayısı 4
Sayfalar 346 - 349
Yayın Yılı 2014
Eser Adı
[dc.title]
Effects of folinic acid and fluorouracil chemotherapy on right ventricle functions as assessed with tricuspid annular plane systolic excursion
Yazar
[dc.contributor.author]
Bilir C.
Yazar
[dc.contributor.author]
Engin H.
Yazar
[dc.contributor.author]
Karabag T.
Yazar
[dc.contributor.author]
Colak D.
Yayın Yılı
[dc.date.issued]
2014
Yayıncı
[dc.publisher]
Lithografia Antoniadis I - Psarras Th G.P.
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Aim: This study aimed to investigate the effects of folinic acid and fluorouracil (bolus FUFA regimen) chemotherapy on right ventricle (RV) functions. Materials and Methods: Thirty-four gastrointestinal (GI) cancer patients treated with antineoplastic drugs were included the study. All participants received FUFA chemotherapy protocol for colorectal, gastric and pancreatic cancer (i.e. fluorouracil 400-425 mg/m2 intravenous day 1-5 + folinic acid 20-25 mg/m2 intravenous day 1-5 every 28 days x6 cycles) with or without radiation therapy according to the cancer and patient status. All participants have undergone complete physical and laboratory examination and complete echocardiographic evaluation including detailed right ventricle functional evaluations before the onset of chemotherapy and 6 months after the start of treatment. Results: Mean RV thickness was 0.49 cm before chemotherapy and 0.62 cm at the end of the treatment (p=0.29). Mean tricuspid annular plane systolic excursion (TAPSE) values were 2.08 ± 0.3 and 2.00 ± 0.39 cm, respectively (p=0.25). RV total ejection isovolumic (Tei) index related to the chemotherapy did not change significantly (0.24 and 0.29, respectively, p=0.07). Also we did not find significant chance in the RV end diastolic diameter, RV end systolic diameter, vena cava diameter on inspiration and expiration. Conclusion: Bolus FUFA regimen chemotherapy does not diminish the RV functions as assessed by TAPSE and RV Tei index in GI cancer patients. © 2014, Hippokratia General Hospital of Thessaloniki. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Chemotherapy
Konu Başlıkları
[dc.subject]
Fluorouracil
Konu Başlıkları
[dc.subject]
Folinic acid
Konu Başlıkları
[dc.subject]
Right ventricular function
Konu Başlıkları
[dc.subject]
Total ejection isovolumic index
Konu Başlıkları
[dc.subject]
Tricuspid annular plane systolic excursion
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1108-4189
İlk Sayfa Sayısı
[dc.identifier.startpage]
346
Son Sayfa Sayısı
[dc.identifier.endpage]
349
Dergi Adı
[dc.relation.journal]
Hippokratia
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
18
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5474
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
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Görüntülenme
241
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
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10 Haziran 2024 22:51
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chemotherapy cancer diameter treatment systolic participants complete respectively before intravenous fluorouracil functions folinic patients ventricle ejection isovolumic diminish Hippokratia General values Hospital (TAPSE) excursion Thessaloniki rights annular reserved related assessed regimen Conclusion expiration inspiration diastolic
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