Cytomorphometric characteristics of buccal mucosal cells in Behçet's disease patients

Background. The aim of this study was to compare the cytomorphometric characteristics of the buccal cells of Behçet's disease patients with those of healthy controls. Methods. This case-control study compared a group of 30 patients with Behçet's disease with an age- and gender-matched control group of 30 healthy individuals. The buccal mucosal smears were stained using the Papanicolaou technique for cytomorphometric analyses. The nuclear and cytoplasmic areas were evaluated using digital image analysis; the ratio of nuclear to cytoplasmic areas and nuclear roundness are presented. Results. The nuclear and cytoplasmic areas of the BD patients' cells were significantly smaller than those of the healthy controls' cells, while the nucleus-to-cytoplasm ratio and neutrophil infiltration rate did not differ significantly between the groups. However, the nuclear area, cytoplasmic area, nucleus-to-cytoplasm ratio, and nuclear roundness factor were significantly higher in patients without aphthae. The neutrophil infiltration rate did not differ significantly in patients with or without aphthae. Conclusion. Behçet's disease can produce cytomorphometric changes in buccal cells that are detectable by exfoliative cytology and cytomorphometric analysis techniques. © 2016 Erol Aktunc et al.

Yazar Aktunc E.
Oz Z.S.
Bektas S.
Altinyazar C.
Koca R.
Bostan S.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4974
Tek Biçim Adres 10.1155/2016/6035801
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Analytical Cellular Pathology
Dergi Cilt Bilgisi 2016
Sayfalar -
Yayın Yılı 2016
Eser Adı
[dc.title]
Cytomorphometric characteristics of buccal mucosal cells in Behçet's disease patients
Yazar
[dc.contributor.author]
Aktunc E.
Yazar
[dc.contributor.author]
Oz Z.S.
Yazar
[dc.contributor.author]
Bektas S.
Yazar
[dc.contributor.author]
Altinyazar C.
Yazar
[dc.contributor.author]
Koca R.
Yazar
[dc.contributor.author]
Bostan S.
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
Hindawi Limited
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background. The aim of this study was to compare the cytomorphometric characteristics of the buccal cells of Behçet's disease patients with those of healthy controls. Methods. This case-control study compared a group of 30 patients with Behçet's disease with an age- and gender-matched control group of 30 healthy individuals. The buccal mucosal smears were stained using the Papanicolaou technique for cytomorphometric analyses. The nuclear and cytoplasmic areas were evaluated using digital image analysis; the ratio of nuclear to cytoplasmic areas and nuclear roundness are presented. Results. The nuclear and cytoplasmic areas of the BD patients' cells were significantly smaller than those of the healthy controls' cells, while the nucleus-to-cytoplasm ratio and neutrophil infiltration rate did not differ significantly between the groups. However, the nuclear area, cytoplasmic area, nucleus-to-cytoplasm ratio, and nuclear roundness factor were significantly higher in patients without aphthae. The neutrophil infiltration rate did not differ significantly in patients with or without aphthae. Conclusion. Behçet's disease can produce cytomorphometric changes in buccal cells that are detectable by exfoliative cytology and cytomorphometric analysis techniques. © 2016 Erol Aktunc et al.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
2210-7177
Dergi Adı
[dc.relation.journal]
Analytical Cellular Pathology
Dergi Cilt Bilgisi
[dc.identifier.volume]
2016
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1155/2016/6035801
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4974
Görüntülenme Sayısı ( Şehir )
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16
09.12.2022 tarihinden bu yana
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1
09.12.2022 tarihinden bu yana
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09 Şubat 2024 09:28
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nuclear patients cytomorphometric significantly cytoplasmic healthy disease Behçet buccal roundness analysis differ nucleus-to-cytoplasm without aphthae neutrophil infiltration controls produce Aktunc between groups techniques However cytology exfoliative factor higher detectable changes Conclusion Background evaluated control compare
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