Examination of lung toxicity, oxidant/antioxidant status and effect of erdosteine in rats kept in coal mine ambience

Occupational exposure to coal dust causes pneumoconiosis and other diseases. Reactive oxygen species (ROS) have been implicated in the pathogenesis of coal dust-induced lung toxicity. In this experimental study, we investigated the oxidant/antioxidant status, nitric oxide (NO) and hydroxyproline (HP) levels in lungs and blood of rats exposed to coal dust in mine ambience. In addition, we also investigated the attenuating effects of erdosteine. At the end of the experiment processes, tissue levels of HP, malondialdehyde (MDA) and NO, as well as the activities of superoxide dismutase, glutathione peroxidase, catalase, xanthine oxidase (XO), myeloperoxidase (MPO) and proinflammatory cytokines (IL-6 and TNF-?) were evaluated in the lung tissues, plasma samples or erythrocytes of rats. Exposure to coal dust resulted in a significant increase in the oxidant parameters (MDA, NO levels, and XO activity) and HP levels, as compared to the controls. A decrease in activities of antioxidant enzymes, and an increase in MPO activity were found in the study group, compared to the controls. Increased NO levels of lung were found in the study groups, that were significantly reduced by erdosteine. Our studies provide evidence that supports the hypothesis for ROS mediated coal workers' pneumoconiosis. Erdosteine may be beneficial in the coal dust-induced lung toxicity via antioxidant and free radical scavenger properties. © 2007 Elsevier B.V. All rights reserved.

Yazar Armutcu F.
Gun B.D.
Altin R.
Gurel A.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/5802
Tek Biçim Adres 10.1016/j.etap.2007.03.002
Konu Başlıkları Antioxidant enzymes
Coal mine ambience
Erdosteine
Oxidative stress
Rats
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Environmental Toxicology and Pharmacology
Dergi Cilt Bilgisi 24
Dergi Sayısı 2
Sayfalar 106 - 113
Yayın Yılı 2007
Eser Adı
[dc.title]
Examination of lung toxicity, oxidant/antioxidant status and effect of erdosteine in rats kept in coal mine ambience
Yazar
[dc.contributor.author]
Armutcu F.
Yazar
[dc.contributor.author]
Gun B.D.
Yazar
[dc.contributor.author]
Altin R.
Yazar
[dc.contributor.author]
Gurel A.
Yayın Yılı
[dc.date.issued]
2007
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Occupational exposure to coal dust causes pneumoconiosis and other diseases. Reactive oxygen species (ROS) have been implicated in the pathogenesis of coal dust-induced lung toxicity. In this experimental study, we investigated the oxidant/antioxidant status, nitric oxide (NO) and hydroxyproline (HP) levels in lungs and blood of rats exposed to coal dust in mine ambience. In addition, we also investigated the attenuating effects of erdosteine. At the end of the experiment processes, tissue levels of HP, malondialdehyde (MDA) and NO, as well as the activities of superoxide dismutase, glutathione peroxidase, catalase, xanthine oxidase (XO), myeloperoxidase (MPO) and proinflammatory cytokines (IL-6 and TNF-?) were evaluated in the lung tissues, plasma samples or erythrocytes of rats. Exposure to coal dust resulted in a significant increase in the oxidant parameters (MDA, NO levels, and XO activity) and HP levels, as compared to the controls. A decrease in activities of antioxidant enzymes, and an increase in MPO activity were found in the study group, compared to the controls. Increased NO levels of lung were found in the study groups, that were significantly reduced by erdosteine. Our studies provide evidence that supports the hypothesis for ROS mediated coal workers' pneumoconiosis. Erdosteine may be beneficial in the coal dust-induced lung toxicity via antioxidant and free radical scavenger properties. © 2007 Elsevier B.V. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Antioxidant enzymes
Konu Başlıkları
[dc.subject]
Coal mine ambience
Konu Başlıkları
[dc.subject]
Erdosteine
Konu Başlıkları
[dc.subject]
Oxidative stress
Konu Başlıkları
[dc.subject]
Rats
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1382-6689
Sponsor YAYINCI
[dc.description.sponsorship]
Fundamental Research Fund of Shandong University
Sponsor YAYINCI
[dc.description.sponsorship]
This study was supported by a grant (2002/019) of the Zonguldak Karaelmas University Research Fund.
İlk Sayfa Sayısı
[dc.identifier.startpage]
106
Son Sayfa Sayısı
[dc.identifier.endpage]
113
Dergi Adı
[dc.relation.journal]
Environmental Toxicology and Pharmacology
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
24
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.etap.2007.03.002
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5802
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
33
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
19 Şubat 2024 13:38
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levels controls erdosteine dust-induced toxicity compared activities investigated increase antioxidant pneumoconiosis activity Increased groups Occupational enzymes decrease activity) parameters oxidant significant resulted significantly hypothesis reduced reserved rights Elsevier properties scavenger radical beneficial Erdosteine workers mediated
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