Comparison of the Analgesic Effects of Dexketoprofen and Diclofenac during Shockwave Lithotripsy: A randomized, double-blind clinical trial

Background and Purpose: This prospective, randomized, and double-blind clinical study aimed to assess the analgesic efficacy of single-dose intramuscular (IM) injection of dexketoprofen (group DE) compared with single-dose IM injection of diclofenac (group DI) in patients who were undergoing shockwave lithotripsy (SWL). Patients and Methods: A total of 70 men with single renal or ureteral stones were randomly separated into two groups. The 40 men in group DI received 75mg IM diclofenac sodium and 30 men in Group DE received 50mg IM dexketoprofen trometamol 30 minutes before SWL. A 10-point visual analog scale was used to evaluate pain. Results: The age, body mass index, and mean stone burden were comparable between the two groups (P>0.05). The mean visual analog scale score for group DE was statistically lower compared with the score for group DI (P=0.02). In 34 (85%) of the 40 men in group DI, the SWL procedure was performed with no, minor, or tolerable pain. In group DE, however, 28 (93.3%) of 30 patients evaluated the pain severity as no, minor, or tolerable (p=0.01). No major/minor adverse effects were observed in group DI, whereas in one patient in group DE, dyspepsia after injection was noticed (P=0.423). Conclusions: The severity of SWL-related pain was significantly better tolerated with dexketoprofen trometamol. During an SWL procedure, the analgesic efficacy of dexketoprofen was greater than that of diclofenac sodium. Although statistically insignificant, a little increased risk for gastric irritation was noticed with dexketoprofen. © Mary Ann Liebert, Inc. 2010.

Yazar Tokgoz H.
Yurtlu S.
Hanci V.
Turksoy O.
Erol B.
Akduman B.
Mungan A.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4837
Tek Biçim Adres 10.1089/end.2009.0257
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Journal of Endourology
Dergi Cilt Bilgisi 24
Dergi Sayısı 6
Sayfalar 1031 - 1035
Yayın Yılı 2010
Eser Adı
[dc.title]
Comparison of the Analgesic Effects of Dexketoprofen and Diclofenac during Shockwave Lithotripsy: A randomized, double-blind clinical trial
Yazar
[dc.contributor.author]
Tokgoz H.
Yazar
[dc.contributor.author]
Yurtlu S.
Yazar
[dc.contributor.author]
Hanci V.
Yazar
[dc.contributor.author]
Turksoy O.
Yazar
[dc.contributor.author]
Erol B.
Yazar
[dc.contributor.author]
Akduman B.
Yazar
[dc.contributor.author]
Mungan A.
Yayın Yılı
[dc.date.issued]
2010
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background and Purpose: This prospective, randomized, and double-blind clinical study aimed to assess the analgesic efficacy of single-dose intramuscular (IM) injection of dexketoprofen (group DE) compared with single-dose IM injection of diclofenac (group DI) in patients who were undergoing shockwave lithotripsy (SWL). Patients and Methods: A total of 70 men with single renal or ureteral stones were randomly separated into two groups. The 40 men in group DI received 75mg IM diclofenac sodium and 30 men in Group DE received 50mg IM dexketoprofen trometamol 30 minutes before SWL. A 10-point visual analog scale was used to evaluate pain. Results: The age, body mass index, and mean stone burden were comparable between the two groups (P>0.05). The mean visual analog scale score for group DE was statistically lower compared with the score for group DI (P=0.02). In 34 (85%) of the 40 men in group DI, the SWL procedure was performed with no, minor, or tolerable pain. In group DE, however, 28 (93.3%) of 30 patients evaluated the pain severity as no, minor, or tolerable (p=0.01). No major/minor adverse effects were observed in group DI, whereas in one patient in group DE, dyspepsia after injection was noticed (P=0.423). Conclusions: The severity of SWL-related pain was significantly better tolerated with dexketoprofen trometamol. During an SWL procedure, the analgesic efficacy of dexketoprofen was greater than that of diclofenac sodium. Although statistically insignificant, a little increased risk for gastric irritation was noticed with dexketoprofen. © Mary Ann Liebert, Inc. 2010.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0892-7790
İlk Sayfa Sayısı
[dc.identifier.startpage]
1031
Son Sayfa Sayısı
[dc.identifier.endpage]
1035
Dergi Adı
[dc.relation.journal]
Journal of Endourology
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
24
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1089/end.2009.0257
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4837
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
24
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 09:32
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dexketoprofen diclofenac injection visual procedure groups statistically received analog sodium tolerable severity trometamol noticed efficacy single-dose (group analgesic compared patients evaluated significantly gastric however irritation Liebert performed major/minor increased greater Conclusions better dyspepsia patient tolerated
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