Effect of Topical and Intravenously Applied Tranexamic Acid Compared to Control Group on Bleeding in Primary Unilateral Total Knee Arthroplasty

We aimed to answer the following three questions in this study: (1) Does tranexamic acid (TA) reduce the amount of bleeding in total knee arthroplasty (TKA)? (2) Does TA reduce requirement for blood transfusion? (3) Is there any difference on reliability and efficacy between topical and intravenous (IV) applications of TA? Patients were allocated into three groups randomly by a software program as topical, IV, and control group. TA was applied as 20 mg/kg to the IV group and as 3 g/100 mL saline to the topical group. The hemoglobin values were recorded preoperatively and postoperatively on the same day and on day 1 and day 2. Removal of the drain postoperatively and length of hospital stay, as well as any complications such as pulmonary embolism or deep venous thrombosis, were also noted. The study comprised 40 patients in the IV group, 42 in the topical group, and 41 in the control group. The drain output values were similar in the IV and topical groups (p = 0.161), while those of the control group were significantly higher than both the IV and topical groups (p < 0.001 and < 0.001). Transfusion was applied to 19.5% of cases in the control group, 4.8% in the topical group, and 5.1% of the IV group (? 2 = 6.522; p = 0.038). The results of the study showed that 20 mg/kg single-dose IV bolus or 3 g topical TA application reduced blood loss and transfusion requirement without increasing the rate of thromboembolic complications in unilateral primary TKA. © Copyright 2017 by Thieme Medical Publishers, Inc.

Yazar Ugurlu M.
Aksekili M.A.E.
Çaglar C.
Yüksel K.
Şahin E.
Akyol M.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/5398
Tek Biçim Adres 10.1055/s-0036-1583270
Konu Başlıkları hemoglobin
intravenous
topical
total knee arthroplasty
tranexamic acid
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Journal of Knee Surgery
Dergi Cilt Bilgisi 30
Dergi Sayısı 2
Sayfalar 152 - 157
Yayın Yılı 2017
Eser Adı
[dc.title]
Effect of Topical and Intravenously Applied Tranexamic Acid Compared to Control Group on Bleeding in Primary Unilateral Total Knee Arthroplasty
Yazar
[dc.contributor.author]
Ugurlu M.
Yazar
[dc.contributor.author]
Aksekili M.A.E.
Yazar
[dc.contributor.author]
Çaglar C.
Yazar
[dc.contributor.author]
Yüksel K.
Yazar
[dc.contributor.author]
Şahin E.
Yazar
[dc.contributor.author]
Akyol M.
Yayın Yılı
[dc.date.issued]
2017
Yayıncı
[dc.publisher]
Georg Thieme Verlag
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
We aimed to answer the following three questions in this study: (1) Does tranexamic acid (TA) reduce the amount of bleeding in total knee arthroplasty (TKA)? (2) Does TA reduce requirement for blood transfusion? (3) Is there any difference on reliability and efficacy between topical and intravenous (IV) applications of TA? Patients were allocated into three groups randomly by a software program as topical, IV, and control group. TA was applied as 20 mg/kg to the IV group and as 3 g/100 mL saline to the topical group. The hemoglobin values were recorded preoperatively and postoperatively on the same day and on day 1 and day 2. Removal of the drain postoperatively and length of hospital stay, as well as any complications such as pulmonary embolism or deep venous thrombosis, were also noted. The study comprised 40 patients in the IV group, 42 in the topical group, and 41 in the control group. The drain output values were similar in the IV and topical groups (p = 0.161), while those of the control group were significantly higher than both the IV and topical groups (p < 0.001 and < 0.001). Transfusion was applied to 19.5% of cases in the control group, 4.8% in the topical group, and 5.1% of the IV group (? 2 = 6.522; p = 0.038). The results of the study showed that 20 mg/kg single-dose IV bolus or 3 g topical TA application reduced blood loss and transfusion requirement without increasing the rate of thromboembolic complications in unilateral primary TKA. © Copyright 2017 by Thieme Medical Publishers, Inc.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
hemoglobin
Konu Başlıkları
[dc.subject]
intravenous
Konu Başlıkları
[dc.subject]
topical
Konu Başlıkları
[dc.subject]
total knee arthroplasty
Konu Başlıkları
[dc.subject]
tranexamic acid
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1538-8506
İlk Sayfa Sayısı
[dc.identifier.startpage]
152
Son Sayfa Sayısı
[dc.identifier.endpage]
157
Dergi Adı
[dc.relation.journal]
Journal of Knee Surgery
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
30
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1055/s-0036-1583270
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5398
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
23
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 12:07
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topical control groups postoperatively values requirement reduce complications applied Transfusion significantly similar output higher without increasing thromboembolic unilateral primary Copyright Thieme Medical Publishers transfusion reduced application results showed single-dose patients comprised (TKA)? intravenous between efficacy
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