Effects of short-term treatment with simvastatin on serum lipids in patients with hypercholesterolemia

Hypolipidemic effects of simvastatin, a competitive inhibitor of 3-hydroxymethyl glutaryl coenzyme A (HMG CoA) reductase in thirteen patients (8 women and 5 men, aged between 55-74 years) with hypercholesterolemia were investigated. Hypercholesterolemic patients were treated with simvastatin in a dose of 10 mg daily for 4 weeks. No drug was used these patients in the weeks 5-8. At the end of these period, Simvastatin was given again in a dose of 20 mg daily in the weeks 9-12. Serum total, LDL and HDL-cholesterol and triglycerides in patients with hypercholesterolemia were determined before and under treatment with 10 or 20 mg of simvastatin daily. Blood samples were drawn at every 4 weeks for serum lipids. Serum lipids were also determined for thirteen healthy subjects. Significant decreases were noted under treatment with 10 mg of simvastatin/day in serum cholesterol and low density lipoprotein-cholesterol (p<0.05) in the weeks 1-4, however an unaltered levels in serum triglycerides and high density lipoprotein-cholesterol were observed. Total and LDL-cholesterol increased at the end of untreated period (p<0.05), but HDL-cholesterol and triglycerides did not change significantly. After 12 weeks serum total and LDL-cholesterol were reduced with 20 mg of simvastatin/day (p<0.05), but triglycerides and HDL-cholesterol remained unchanged under simvastatin treatment. We conclude that simvastatin is effective in lowering total and LDL-cholesterol in patients with hypercholesterolemia during short-term administration.

Yazar Can C.
Gönenç A.
Açikgöz Ş.
Şimşek B.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/5525
Konu Başlıkları Hypercholesterolemia
Lipids
Simvastatin
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Gazi Universitesi Eczacilik Fakultesi Dergisi
Dergi Cilt Bilgisi 19
Dergi Sayısı 2
Sayfalar 93 - 100
Yayın Yılı 2002
Eser Adı
[dc.title]
Effects of short-term treatment with simvastatin on serum lipids in patients with hypercholesterolemia
Yazar
[dc.contributor.author]
Can C.
Yazar
[dc.contributor.author]
Gönenç A.
Yazar
[dc.contributor.author]
Açikgöz Ş.
Yazar
[dc.contributor.author]
Şimşek B.
Yayın Yılı
[dc.date.issued]
2002
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Hypolipidemic effects of simvastatin, a competitive inhibitor of 3-hydroxymethyl glutaryl coenzyme A (HMG CoA) reductase in thirteen patients (8 women and 5 men, aged between 55-74 years) with hypercholesterolemia were investigated. Hypercholesterolemic patients were treated with simvastatin in a dose of 10 mg daily for 4 weeks. No drug was used these patients in the weeks 5-8. At the end of these period, Simvastatin was given again in a dose of 20 mg daily in the weeks 9-12. Serum total, LDL and HDL-cholesterol and triglycerides in patients with hypercholesterolemia were determined before and under treatment with 10 or 20 mg of simvastatin daily. Blood samples were drawn at every 4 weeks for serum lipids. Serum lipids were also determined for thirteen healthy subjects. Significant decreases were noted under treatment with 10 mg of simvastatin/day in serum cholesterol and low density lipoprotein-cholesterol (p<0.05) in the weeks 1-4, however an unaltered levels in serum triglycerides and high density lipoprotein-cholesterol were observed. Total and LDL-cholesterol increased at the end of untreated period (p<0.05), but HDL-cholesterol and triglycerides did not change significantly. After 12 weeks serum total and LDL-cholesterol were reduced with 20 mg of simvastatin/day (p<0.05), but triglycerides and HDL-cholesterol remained unchanged under simvastatin treatment. We conclude that simvastatin is effective in lowering total and LDL-cholesterol in patients with hypercholesterolemia during short-term administration.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Hypercholesterolemia
Konu Başlıkları
[dc.subject]
Lipids
Konu Başlıkları
[dc.subject]
Simvastatin
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1015-9592
İlk Sayfa Sayısı
[dc.identifier.startpage]
93
Son Sayfa Sayısı
[dc.identifier.endpage]
100
Dergi Adı
[dc.relation.journal]
Gazi Universitesi Eczacilik Fakultesi Dergisi
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
19
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5525
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
153
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
15 Temmuz 2024 21:10
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simvastatin patients triglycerides HDL-cholesterol LDL-cholesterol treatment hypercholesterolemia period density determined thirteen lipoprotein-cholesterol lipids simvastatin/day effective lowering cholesterol short-term administration however during change Significant significantly untreated reduced remained unchanged increased conclude observed levels unaltered decreases Hypolipidemic
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