Effect of defective collagen synthesis on epithelial implant interface: Lathyritic model in dogs. An experimental preliminary study

Peri-implant mucosa is composed of 2 compartments: a marginal junctional epithelium and a zone of connective tissue attachment. Both structures consist mainly of collagen. Lathyrism is characterized by defective collagen synthesis due to inhibition of lysyl oxidase, an enzyme that is essential for interfibrillar collagen cross-linking. The lathyritic agent beta- aminoproprionitrile (ß-APN) is considered a suitable agent to disrupt the connective tissue metabolism. Therefore, the purpose of this study was to assess the effect of defective connective tissue metabolism on epithelial implant interface by using ß-APN created chronic lathyrism in the canine model. Two 1-year-old male dogs were included in this study. A ß-APN dosage of 5 mg/0.4 mL/volume 100 g/body weight was given to the test dog for 10 months, until lathyritic symptoms developed. After this, the mandibular premolar teeth (p2, p3, p4) of both dogs were atraumatically extracted, and the investigators waited 3 months before implants were placed. In the test dog, 3 implants were placed in the left mandible, and 2 implants were placed in the right mandible. In the control dog, 2 implants were placed in the left mandibular premolar site. The dogs were sacrificed 10 months after healing. Periimplant tissues obtained from the dogs were examined histomorphologically and histopathologically. Bone to implant contact (BIC) values and bone volumes (BV) were lower in the lathyritic group compared to the control group; however, no statistical significance was found. Significant histologic and histomorphometric changes were observed in periimplant bone, connective tissue, and peri-implant mucosal width between test and control implants. Defective collagen metabolism such as lathyrism may negatively influence the interface between implant and surrounding soft tissue attachment.

Yazar Cengiz M.I.
Lu T.K.
Acikgoz G.
Trisi P.
Wang H.-L.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/5295
Tek Biçim Adres 10.1563/AAID-JOI-D-09-00133
Konu Başlıkları Collagen crosslinking
Defective collagen synthesis
Peri-implant mucosa
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Journal of Oral Implantology
Dergi Cilt Bilgisi 38
Dergi Sayısı 2
Sayfalar 105 - 114
Yayın Yılı 2012
Eser Adı
[dc.title]
Effect of defective collagen synthesis on epithelial implant interface: Lathyritic model in dogs. An experimental preliminary study
Yazar
[dc.contributor.author]
Cengiz M.I.
Yazar
[dc.contributor.author]
Lu T.K.
Yazar
[dc.contributor.author]
Acikgoz G.
Yazar
[dc.contributor.author]
Trisi P.
Yazar
[dc.contributor.author]
Wang H.-L.
Yayın Yılı
[dc.date.issued]
2012
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Peri-implant mucosa is composed of 2 compartments: a marginal junctional epithelium and a zone of connective tissue attachment. Both structures consist mainly of collagen. Lathyrism is characterized by defective collagen synthesis due to inhibition of lysyl oxidase, an enzyme that is essential for interfibrillar collagen cross-linking. The lathyritic agent beta- aminoproprionitrile (ß-APN) is considered a suitable agent to disrupt the connective tissue metabolism. Therefore, the purpose of this study was to assess the effect of defective connective tissue metabolism on epithelial implant interface by using ß-APN created chronic lathyrism in the canine model. Two 1-year-old male dogs were included in this study. A ß-APN dosage of 5 mg/0.4 mL/volume 100 g/body weight was given to the test dog for 10 months, until lathyritic symptoms developed. After this, the mandibular premolar teeth (p2, p3, p4) of both dogs were atraumatically extracted, and the investigators waited 3 months before implants were placed. In the test dog, 3 implants were placed in the left mandible, and 2 implants were placed in the right mandible. In the control dog, 2 implants were placed in the left mandibular premolar site. The dogs were sacrificed 10 months after healing. Periimplant tissues obtained from the dogs were examined histomorphologically and histopathologically. Bone to implant contact (BIC) values and bone volumes (BV) were lower in the lathyritic group compared to the control group; however, no statistical significance was found. Significant histologic and histomorphometric changes were observed in periimplant bone, connective tissue, and peri-implant mucosal width between test and control implants. Defective collagen metabolism such as lathyrism may negatively influence the interface between implant and surrounding soft tissue attachment.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Collagen crosslinking
Konu Başlıkları
[dc.subject]
Defective collagen synthesis
Konu Başlıkları
[dc.subject]
Peri-implant mucosa
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0160-6972
İlk Sayfa Sayısı
[dc.identifier.startpage]
105
Son Sayfa Sayısı
[dc.identifier.endpage]
114
Dergi Adı
[dc.relation.journal]
Journal of Oral Implantology
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
38
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1563/AAID-JOI-D-09-00133
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5295
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
3
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Kasım 2023 06:51
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Tıklayınız
implants tissue collagen connective placed lathyritic metabolism control implant months premolar lathyrism ß-APN defective interface mandibular attachment between mandible waited atraumatically obtained tissues Periimplant healing sacrificed before extracted investigators Peri-implant examined Defective changes observed periimplant
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