Effect of oophorectomy and exogenous estrogen replacement on liver injury in experimental obstructive jaundice

Aim: To investigate the role of estrogen on liver injury in an experimental obstructive jaundice model. Methods: Three groups of female rats were constituted; group 1 was oophorectomized and given E2 (n 14), group 2 was oophorectomized and given placebo (n 14), and group 3 was sham operated (n = 14). Fourteen days following constitution of bile duct ligation, all groups were compared in terms of serum tests, histopathologic parameters, and tissue levels of IFN-? and IL-6. Results: The parameters representing both the injury and/or the reactive response and healing were more pronounced in groups 1 and 2 (? 2 = 17.2, ?2 = 10.20; ?2 = 12.4, P < 0.05). In the sham operated or E2 administered groups significantly lower tissue levels of IFN-? and higher IL-6 levels Were found. In contrast, high IFN-? and low IL-6 tissue levels were found in the oophorectomized and placebo group (P < 0.001). Kupffer cell alterations were observed to be more pronounced in the groups 1 and 3 (?2 = 6.13, P < 0.05). Conclusion: Our study indicates that E2 impaired liver functions, accelerated both the liver damage and healing. In the conditions of bile duct obstruction, estrogen significantly changed the cytokine milieu in the liver. © 2008 WJG. All rights reserved.

Yazar Uçan H.B.
Kaplan M.
Salman B.
Yilmaz U.
Menteş B.B.
Aybay C.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/5352
Tek Biçim Adres 10.3748/wjg.14.2818
Konu Başlıkları Estrogen
Liver injury
Obstructive jaundice
Oophorectomy
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı World Journal of Gastroenterology
Dergi Cilt Bilgisi 14
Dergi Sayısı 18
Sayfalar 2818 - 2824
Yayın Yılı 2008
Eser Adı
[dc.title]
Effect of oophorectomy and exogenous estrogen replacement on liver injury in experimental obstructive jaundice
Yazar
[dc.contributor.author]
Uçan H.B.
Yazar
[dc.contributor.author]
Kaplan M.
Yazar
[dc.contributor.author]
Salman B.
Yazar
[dc.contributor.author]
Yilmaz U.
Yazar
[dc.contributor.author]
Menteş B.B.
Yazar
[dc.contributor.author]
Aybay C.
Yayın Yılı
[dc.date.issued]
2008
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Aim: To investigate the role of estrogen on liver injury in an experimental obstructive jaundice model. Methods: Three groups of female rats were constituted; group 1 was oophorectomized and given E2 (n 14), group 2 was oophorectomized and given placebo (n 14), and group 3 was sham operated (n = 14). Fourteen days following constitution of bile duct ligation, all groups were compared in terms of serum tests, histopathologic parameters, and tissue levels of IFN-? and IL-6. Results: The parameters representing both the injury and/or the reactive response and healing were more pronounced in groups 1 and 2 (? 2 = 17.2, ?2 = 10.20; ?2 = 12.4, P < 0.05). In the sham operated or E2 administered groups significantly lower tissue levels of IFN-? and higher IL-6 levels Were found. In contrast, high IFN-? and low IL-6 tissue levels were found in the oophorectomized and placebo group (P < 0.001). Kupffer cell alterations were observed to be more pronounced in the groups 1 and 3 (?2 = 6.13, P < 0.05). Conclusion: Our study indicates that E2 impaired liver functions, accelerated both the liver damage and healing. In the conditions of bile duct obstruction, estrogen significantly changed the cytokine milieu in the liver. © 2008 WJG. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Estrogen
Konu Başlıkları
[dc.subject]
Liver injury
Konu Başlıkları
[dc.subject]
Obstructive jaundice
Konu Başlıkları
[dc.subject]
Oophorectomy
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1007-9327
İlk Sayfa Sayısı
[dc.identifier.startpage]
2818
Son Sayfa Sayısı
[dc.identifier.endpage]
2824
Dergi Adı
[dc.relation.journal]
World Journal of Gastroenterology
Dergi Sayısı
[dc.identifier.issue]
18
Dergi Cilt Bilgisi
[dc.identifier.volume]
14
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.3748/wjg.14.2818
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5352
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
16
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Mart 2024 18:56
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Tıklayınız
groups levels tissue oophorectomized pronounced parameters significantly healing estrogen operated placebo injury higher Kupffer contrast alterations observed conditions reserved rights milieu cytokine changed obstruction damage accelerated functions impaired indicates Conclusion administered Fourteen constituted female Methods
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