Effect of prophylactic antibiotic use in the development of antibiotic resistance in children with recurrent urinary tract infections [Tekrarlayan idrar yolu enfeksiyonunda profilaktik amaçlı antibiyotik kullanımının çocuklarda antibiyotik direnç gelişimine etkisi]

Aim: Although prophylactic antibiotic treatment is still debatable, it is currently in use in recurrent urinary tract infections (UTIs). In the present study, we aimed to observe if prophylactic antibiotic use had any effect on the development of antibiotic resistance in patients with recurrent UTIs who we followed up in our clinic. Methods: The present study was performed on patients aged between one month and 16 years, who had recurrent UTIs, and were followed up by the Department of Pediatrics at Bülent Ecevit University Medical School. Patient files were retrospectively reviewed, and 50 patients who received antibiotic prophylaxis and 100 patients without prophylaxis were enrolled in the study. Urinary tests, subsequent urinary culture results, and antibiotic resistances were compared between the groups. Results: The mean age was 42.7±44.2 months. The most frequently cultured isolated bacterium was Escherichia coli (E. coli) (58.4%). No difference was determined in bacteria in cultures between prophylaxis receivers and non-receivers. Isolation rate of E. coli was higher in urinary cultures in females than in males (p<0.001). When antibiotic resistance of all urinary culture-isolated bacteria was compared between the two groups, there was no statistically significant difference. However, an increased resistance against amoxicillin/clavulanic acid, ceftriaxone, and piperacillin was determined in prophylaxis group in whom E. coli was grown. In this study, general antibiotic resistance was most frequently observed against ampicillin (71.9%). Conclusion: In the present study, we observed that prophylaxis did not contribute so much to resistance other than E. coli. We recommend not preferring antibiotics which have increased resistance in our institution especially in children receiving prophylaxis for empirical treatment. © 2017 by The Medical Bulletin of University of Health Sciences Haseki Training and Research Hospital The Medical Bulletin of Haseki published by Galenos Yayınevi.

Yazar Karacı M.
Karagöz K.
Örnek Z.
Yaşar A.
Yüce N.
Okumuş Ö.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/5366
Tek Biçim Adres 10.4274/haseki.98608
Konu Başlıkları Antibiotic resistance
Childhood
Prophylaxis
Urinary tract infection
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Haseki Tip Bulteni
Dergi Cilt Bilgisi 55
Dergi Sayısı 3
Sayfalar 221 - 228
Yayın Yılı 2017
Eser Adı
[dc.title]
Effect of prophylactic antibiotic use in the development of antibiotic resistance in children with recurrent urinary tract infections [Tekrarlayan idrar yolu enfeksiyonunda profilaktik amaçlı antibiyotik kullanımının çocuklarda antibiyotik direnç gelişimine etkisi]
Yazar
[dc.contributor.author]
Karacı M.
Yazar
[dc.contributor.author]
Karagöz K.
Yazar
[dc.contributor.author]
Örnek Z.
Yazar
[dc.contributor.author]
Yaşar A.
Yazar
[dc.contributor.author]
Yüce N.
Yazar
[dc.contributor.author]
Okumuş Ö.
Yayın Yılı
[dc.date.issued]
2017
Yayıncı
[dc.publisher]
Galenos
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Aim: Although prophylactic antibiotic treatment is still debatable, it is currently in use in recurrent urinary tract infections (UTIs). In the present study, we aimed to observe if prophylactic antibiotic use had any effect on the development of antibiotic resistance in patients with recurrent UTIs who we followed up in our clinic. Methods: The present study was performed on patients aged between one month and 16 years, who had recurrent UTIs, and were followed up by the Department of Pediatrics at Bülent Ecevit University Medical School. Patient files were retrospectively reviewed, and 50 patients who received antibiotic prophylaxis and 100 patients without prophylaxis were enrolled in the study. Urinary tests, subsequent urinary culture results, and antibiotic resistances were compared between the groups. Results: The mean age was 42.7±44.2 months. The most frequently cultured isolated bacterium was Escherichia coli (E. coli) (58.4%). No difference was determined in bacteria in cultures between prophylaxis receivers and non-receivers. Isolation rate of E. coli was higher in urinary cultures in females than in males (p<0.001). When antibiotic resistance of all urinary culture-isolated bacteria was compared between the two groups, there was no statistically significant difference. However, an increased resistance against amoxicillin/clavulanic acid, ceftriaxone, and piperacillin was determined in prophylaxis group in whom E. coli was grown. In this study, general antibiotic resistance was most frequently observed against ampicillin (71.9%). Conclusion: In the present study, we observed that prophylaxis did not contribute so much to resistance other than E. coli. We recommend not preferring antibiotics which have increased resistance in our institution especially in children receiving prophylaxis for empirical treatment. © 2017 by The Medical Bulletin of University of Health Sciences Haseki Training and Research Hospital The Medical Bulletin of Haseki published by Galenos Yayınevi.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Antibiotic resistance
Konu Başlıkları
[dc.subject]
Childhood
Konu Başlıkları
[dc.subject]
Prophylaxis
Konu Başlıkları
[dc.subject]
Urinary tract infection
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1302-0072
İlk Sayfa Sayısı
[dc.identifier.startpage]
221
Son Sayfa Sayısı
[dc.identifier.endpage]
228
Dergi Adı
[dc.relation.journal]
Haseki Tip Bulteni
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
55
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.4274/haseki.98608
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5366
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
11
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Şubat 2024 12:40
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Tıklayınız
antibiotic prophylaxis resistance urinary patients between present Medical recurrent increased against frequently University followed groups compared observed determined bacteria cultures Haseki difference Bulletin treatment prophylactic ceftriaxone piperacillin females amoxicillin/clavulanic However culture-isolated significant statistically Health children
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