Erdosteine ameliorates PTZ-induced oxidative stress in mice seizure model

The role of oxygen-derived free radicals has been suggested in genesis of epilepsy and in the post seizure neuronal death. The aim of this study was to investigate whether erdosteine has a preventive effect against epilepsy and postepileptic oxidative stress. The mice (n = 27) were divided into three groups: (i) PTZ-induced-epilepsy group (n = 9); (ii) PTZ-induced-epilepsy + erdosteine group (n = 9); (iii) control group (n = 9). The animals were observed for a period of 30 min for latency to first seizure onset, total seizure duration, the number of seizure episodes. Then they were sacrificed and the brains were quickly removed, and frozen for biochemical analysis. Malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD) and xanthine oxidase (XO) activities were carried out in the brain tissue. The latent period between PTZ induction and seizure are longer in the PTZ + erdosteine group than in PTZ-induced-epilepsy group (P < 0.05). Biochemical analyses of brain tissue, revealed a significant increase in the MDA, XO and NO levels in the PTZ group according to erdosteine group. SOD level did not change in this group. While MDA and XO levels are significantly lower, SOD level is significantly higher in the PTZ + erdosteine group compared to PTZ and control groups (P < 0.01). The present study demonstrated that erdosteine treatment both may increase latent interval between seizures and may decrease oxidative stress, thus may ameliorate neuronal death in brain during seizures. It may be used as an adjunct therapy in epilepsy. © 2005 Elsevier Inc. All rights reserved.

Yazar Ilhan A.
Aladag M.A.
Kocer A.
Boluk A.
Gurel A.
Armutcu F.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/5659
Tek Biçim Adres 10.1016/j.brainresbull.2005.02.027
Konu Başlıkları Brain
Epilepsy
Erdosteine
Oxidative damage
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Brain Research Bulletin
Dergi Cilt Bilgisi 65
Dergi Sayısı 6
Sayfalar 495 - 499
Yayın Yılı 2005
Eser Adı
[dc.title]
Erdosteine ameliorates PTZ-induced oxidative stress in mice seizure model
Yazar
[dc.contributor.author]
Ilhan A.
Yazar
[dc.contributor.author]
Aladag M.A.
Yazar
[dc.contributor.author]
Kocer A.
Yazar
[dc.contributor.author]
Boluk A.
Yazar
[dc.contributor.author]
Gurel A.
Yazar
[dc.contributor.author]
Armutcu F.
Yayın Yılı
[dc.date.issued]
2005
Yayıncı
[dc.publisher]
Elsevier Inc.
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The role of oxygen-derived free radicals has been suggested in genesis of epilepsy and in the post seizure neuronal death. The aim of this study was to investigate whether erdosteine has a preventive effect against epilepsy and postepileptic oxidative stress. The mice (n = 27) were divided into three groups: (i) PTZ-induced-epilepsy group (n = 9); (ii) PTZ-induced-epilepsy + erdosteine group (n = 9); (iii) control group (n = 9). The animals were observed for a period of 30 min for latency to first seizure onset, total seizure duration, the number of seizure episodes. Then they were sacrificed and the brains were quickly removed, and frozen for biochemical analysis. Malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD) and xanthine oxidase (XO) activities were carried out in the brain tissue. The latent period between PTZ induction and seizure are longer in the PTZ + erdosteine group than in PTZ-induced-epilepsy group (P < 0.05). Biochemical analyses of brain tissue, revealed a significant increase in the MDA, XO and NO levels in the PTZ group according to erdosteine group. SOD level did not change in this group. While MDA and XO levels are significantly lower, SOD level is significantly higher in the PTZ + erdosteine group compared to PTZ and control groups (P < 0.01). The present study demonstrated that erdosteine treatment both may increase latent interval between seizures and may decrease oxidative stress, thus may ameliorate neuronal death in brain during seizures. It may be used as an adjunct therapy in epilepsy. © 2005 Elsevier Inc. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Brain
Konu Başlıkları
[dc.subject]
Epilepsy
Konu Başlıkları
[dc.subject]
Erdosteine
Konu Başlıkları
[dc.subject]
Oxidative damage
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0361-9230
İlk Sayfa Sayısı
[dc.identifier.startpage]
495
Son Sayfa Sayısı
[dc.identifier.endpage]
499
Dergi Adı
[dc.relation.journal]
Brain Research Bulletin
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
65
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.brainresbull.2005.02.027
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5659
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
19
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Nisan 2024 01:22
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Tıklayınız
erdosteine seizure epilepsy PTZ-induced-epilepsy groups tissue increase between control seizures levels period significantly latent neuronal stress oxidative Biochemical therapy reserved significant revealed analyses decrease adjunct longer rights induction according ameliorate during Elsevier treatment demonstrated interval
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