Effects of hyaluronic acid on postoperative adhesion of tendo calcaneus surgery: An experimental study in rats

Adhesions are a significant problem after tendon surgery. The effects of hyaluronic acid on adhesion formation of the tendo calcaneus were investigated in this study. Twenty Wistar rats were utilized. Both tendo calcanei were incised transversely, and then repaired. Hyaluronic acid (0.2 cc) was injected into peritendinous tissue on the right side, while the same amount of normal saline was injected to the left side as a control. The animals were sacrificed 40days after the experiment. Both the right and left tendon adhesions were evaluated both macroscopically and microscopically for the presence of adhesions (grading scale 0-4). Throughout the experimental period, there was no difference in range of motion of the ankle between the two groups. Macroscopically, there were fewer adhesions in the experimental group (mean 0.6 ± 0.8) compared to the controls (mean 1.1 ± 0.2). This difference was not statistically significant (p =. 096). Histopathologically, these parameters were similar in both the experimental (mean 1.15 ± 0.98) and the control groups (mean 1.9 ± 1.25). This difference was significant (p =. 043). Hyaluronic acid may be effective for prevention of adhesions in the tendo calcaneus though this effect could not be demonstrated experimentally.

Yazar Tuncay I.
Ozbek H.
Atik B.
Ozen S.
Akpinar F.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/5484
Tek Biçim Adres 10.1016/S1067-2516(02)80033-3
Konu Başlıkları Adhesion
Hyaluronic acid
Tendo calcaneus
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Journal of Foot and Ankle Surgery
Dergi Cilt Bilgisi 41
Dergi Sayısı 2
Sayfalar 104 - 108
Yayın Yılı 2002
Eser Adı
[dc.title]
Effects of hyaluronic acid on postoperative adhesion of tendo calcaneus surgery: An experimental study in rats
Yazar
[dc.contributor.author]
Tuncay I.
Yazar
[dc.contributor.author]
Ozbek H.
Yazar
[dc.contributor.author]
Atik B.
Yazar
[dc.contributor.author]
Ozen S.
Yazar
[dc.contributor.author]
Akpinar F.
Yayın Yılı
[dc.date.issued]
2002
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Adhesions are a significant problem after tendon surgery. The effects of hyaluronic acid on adhesion formation of the tendo calcaneus were investigated in this study. Twenty Wistar rats were utilized. Both tendo calcanei were incised transversely, and then repaired. Hyaluronic acid (0.2 cc) was injected into peritendinous tissue on the right side, while the same amount of normal saline was injected to the left side as a control. The animals were sacrificed 40days after the experiment. Both the right and left tendon adhesions were evaluated both macroscopically and microscopically for the presence of adhesions (grading scale 0-4). Throughout the experimental period, there was no difference in range of motion of the ankle between the two groups. Macroscopically, there were fewer adhesions in the experimental group (mean 0.6 ± 0.8) compared to the controls (mean 1.1 ± 0.2). This difference was not statistically significant (p =. 096). Histopathologically, these parameters were similar in both the experimental (mean 1.15 ± 0.98) and the control groups (mean 1.9 ± 1.25). This difference was significant (p =. 043). Hyaluronic acid may be effective for prevention of adhesions in the tendo calcaneus though this effect could not be demonstrated experimentally.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Adhesion
Konu Başlıkları
[dc.subject]
Hyaluronic acid
Konu Başlıkları
[dc.subject]
Tendo calcaneus
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1067-2516
İlk Sayfa Sayısı
[dc.identifier.startpage]
104
Son Sayfa Sayısı
[dc.identifier.endpage]
108
Dergi Adı
[dc.relation.journal]
Journal of Foot and Ankle Surgery
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
41
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/S1067-2516(02)80033-3
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5484
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
6
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
22 Ocak 2024 04:08
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Tıklayınız
adhesions experimental difference significant Hyaluronic control injected calcaneus tendon groups motion Macroscopically between Adhesions compared experimentally demonstrated effect though prevention effective controls similar parameters statistically Histopathologically experiment Wistar repaired transversely incised calcanei utilized Twenty investigated
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