Detailed spectral profile analysis of penicillin-induced epileptiform activity in anesthetized rats

Penicillin model is a widely used experimental model for epilepsy research. In the present study we aimed to portray a detailed spectral analysis of penicillin-induced epileptiform activity in comparison with basal brain activity in anesthetized Wistar rats. Male Wistar rats were anesthetized with i.p. urethane and connected to an electrocorticogram setup. After a short period of basal activity recording, epileptic focus was induced by injecting 400 IU/2 µl penicillin-G potassium into the left lateral ventricle while the cortical activity was continuously recorded. Basal activity, latent period and the penicillin-induced epileptiform activity periods were then analyzed using both conventional methods and spectral analysis. Spectral analyses were conducted by dividing the whole spectrum into different frequency bands including delta, theta (slow and fast), alpha-sigma, beta (1 and 2) and gamma (1 and 2) bands. Our results show that the most affected frequency bands were delta, theta, beta-2 and gamma-2 bands during the epileptiform activity and there were marked differences in terms of spectral densities between three investigated episodes (basal activity, latent period and epileptiform activity). Our results may help to analyze novel data obtained using similar experimental models and the simple analysis method described here can be used in similar studies to investigate the basic neuronal mechanism of this or other types of experimental epilepsies. © 2008 Elsevier B.V. All rights reserved.

Dergi Adı Epilepsy Research
Dergi Cilt Bilgisi 82
Dergi Sayısı 1
Sayfalar 7 - 14
Yayın Yılı 2008
Eser Adı
[dc.title]
Detailed spectral profile analysis of penicillin-induced epileptiform activity in anesthetized rats
Yazar
[dc.contributor.author]
Canan S.
Yazar
[dc.contributor.author]
Ankarali S.
Yazar
[dc.contributor.author]
Marangoz C.
Yayın Yılı
[dc.date.issued]
2008
Yayıncı
[dc.publisher]
Elsevier
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Penicillin model is a widely used experimental model for epilepsy research. In the present study we aimed to portray a detailed spectral analysis of penicillin-induced epileptiform activity in comparison with basal brain activity in anesthetized Wistar rats. Male Wistar rats were anesthetized with i.p. urethane and connected to an electrocorticogram setup. After a short period of basal activity recording, epileptic focus was induced by injecting 400 IU/2 µl penicillin-G potassium into the left lateral ventricle while the cortical activity was continuously recorded. Basal activity, latent period and the penicillin-induced epileptiform activity periods were then analyzed using both conventional methods and spectral analysis. Spectral analyses were conducted by dividing the whole spectrum into different frequency bands including delta, theta (slow and fast), alpha-sigma, beta (1 and 2) and gamma (1 and 2) bands. Our results show that the most affected frequency bands were delta, theta, beta-2 and gamma-2 bands during the epileptiform activity and there were marked differences in terms of spectral densities between three investigated episodes (basal activity, latent period and epileptiform activity). Our results may help to analyze novel data obtained using similar experimental models and the simple analysis method described here can be used in similar studies to investigate the basic neuronal mechanism of this or other types of experimental epilepsies. © 2008 Elsevier B.V. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Electrocorticogram
Konu Başlıkları
[dc.subject]
Fast Fourier transformation
Konu Başlıkları
[dc.subject]
Penicillin-induced epileptiform activity
Konu Başlıkları
[dc.subject]
Rat
Konu Başlıkları
[dc.subject]
Spectral analysis
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0920-1211
Sponsor YAYINCI
[dc.description.sponsorship]
Ondokuz Mayis Üniversitesi
Sponsor YAYINCI
[dc.description.sponsorship]
This study was supported in part by Ondokuz Mayis University Research Fund.
İlk Sayfa Sayısı
[dc.identifier.startpage]
7
Son Sayfa Sayısı
[dc.identifier.endpage]
14
Dergi Adı
[dc.relation.journal]
Epilepsy Research
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
82
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.eplepsyres.2008.06.005
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5022
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
137
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
11 Haziran 2024 03:49
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Tıklayınız
activity epileptiform spectral analysis period experimental similar Wistar anesthetized penicillin-induced frequency results latent episodes between investigated densities Penicillin differences marked during gamma-2 beta-2 activity) affected (basal method mechanism reserved rights Elsevier epilepsies neuronal investigate studies
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