Autologous serum skin test versus autologous plasma skin test in patients with chronic spontaneous urticaria

Previous studies indicate that 25-45% of chronic urticaria patients have an autoimmune etiology. Autologous serum skin test (ASST) and autologous plasma skin test (APST) are simple tests for diagnosing chronic autoimmune urticaria (CAU). However, there are still some questions about the specificity of these tests. This study consisted of 50 patients with chronic spontaneous urticaria (CSU) and 50 sex- and age-matched healthy individuals aged 18 years, and older. A total of 31 (62%) patients and 5 (10%) control patients had positive ASST; 21 (42%) patients and 3 (6%) control patients had positive APST. Statistically significant differences were noted in ASST and APST positivity between the patient and control groups (ASST P<0.001; APST P<0.001). Thirteen (26%) patients and 5 (10%) control patients had antithyroglobulin antibodies or antithyroid peroxidase antibody positivity. No statistically significant differences were noted in thyroid autoantibodies between the patient and control groups (anti-TG P=0.317; anti-TPO P=0.269). We consider that the ASST and APST can both be used as in vivo tests for the assessment of autoimmunity in the etiology of CSU and that thyroid autoantibodies should be checked even when thyroid function tests reveal normal results in patients with CSU. © 2013 Aysegul Alpay et al.

Yazar Alpay A.
Solak Tekin N.
Tekin I.Ö.
Altinyazar H.C.
Koca R.
Çnar S.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4454
Tek Biçim Adres 10.1155/2013/267278
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Dermatology Research and Practice
Dergi Cilt Bilgisi 2013
Sayfalar -
Yayın Yılı 2013
Eser Adı
[dc.title]
Autologous serum skin test versus autologous plasma skin test in patients with chronic spontaneous urticaria
Yazar
[dc.contributor.author]
Alpay A.
Yazar
[dc.contributor.author]
Solak Tekin N.
Yazar
[dc.contributor.author]
Tekin I.Ö.
Yazar
[dc.contributor.author]
Altinyazar H.C.
Yazar
[dc.contributor.author]
Koca R.
Yazar
[dc.contributor.author]
Çnar S.
Yayın Yılı
[dc.date.issued]
2013
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Previous studies indicate that 25-45% of chronic urticaria patients have an autoimmune etiology. Autologous serum skin test (ASST) and autologous plasma skin test (APST) are simple tests for diagnosing chronic autoimmune urticaria (CAU). However, there are still some questions about the specificity of these tests. This study consisted of 50 patients with chronic spontaneous urticaria (CSU) and 50 sex- and age-matched healthy individuals aged 18 years, and older. A total of 31 (62%) patients and 5 (10%) control patients had positive ASST; 21 (42%) patients and 3 (6%) control patients had positive APST. Statistically significant differences were noted in ASST and APST positivity between the patient and control groups (ASST P<0.001; APST P<0.001). Thirteen (26%) patients and 5 (10%) control patients had antithyroglobulin antibodies or antithyroid peroxidase antibody positivity. No statistically significant differences were noted in thyroid autoantibodies between the patient and control groups (anti-TG P=0.317; anti-TPO P=0.269). We consider that the ASST and APST can both be used as in vivo tests for the assessment of autoimmunity in the etiology of CSU and that thyroid autoantibodies should be checked even when thyroid function tests reveal normal results in patients with CSU. © 2013 Aysegul Alpay et al.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1687-6113
Dergi Adı
[dc.relation.journal]
Dermatology Research and Practice
Dergi Cilt Bilgisi
[dc.identifier.volume]
2013
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1155/2013/267278
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4454
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13
09.12.2022 tarihinden bu yana
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09.12.2022 tarihinden bu yana
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patients control urticaria chronic thyroid autoantibodies significant positive differences positivity between patient groups autoimmune etiology Thirteen normal results antibodies antithyroglobulin assessment function Aysegul reveal antithyroid autoimmunity should consider checked anti-TPO (anti-TG statistically antibody peroxidase Previous
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