5-fluorouracil encapsulated chitosan nanoparticles for pH-stimulated drug delivery: Evaluation of controlled release kinetics

Nanoparticles consisting of human therapeutic drugs are suggested as a promising strategy for targeted and localized drug delivery to tumor cells. In this study, 5-fluorouracil (5-FU) encapsulated chitosan nanoparticles were prepared in order to investigate potentials of localized drug delivery for tumor environment due to pH sensitivity of chitosan nanoparticles. Optimization of chitosan and 5-FU encapsulated nanoparticles production revealed 148.8±1.1 nm and 243.1±17.9 nm particle size diameters with narrow size distributions, which are confirmed by scanning electron microscope (SEM) images. The challenge was to investigate drug delivery of 5-FU encapsulated chitosan nanoparticles due to varied pH changes. To achieve this objective, pH sensitivity of prepared chitosan nanoparticle was evaluated and results showed a significant swelling response for pH 5 with particle diameter of ~450nm. In vitro release studies indicated a controlled and sustained release of 5-FU from chitosan nanoparticles with the release amounts of 29.1-60.8% due to varied pH environments after 408 h of the incubation period. pH sensitivity is confirmed by mathematical modeling of release kinetics since chitosan nanoparticles showed stimuli-induced release. Results suggested that 5-FU encapsulated chitosan nanoparticles can be launched as pH-responsive smart drug delivery agents for possible applications of cancer treatments. © 2012 R. Seda Tl Aydn and Mehlika Pulat.

Yazar Tigli Aydin R.S.
Pulat M.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3860
Tek Biçim Adres 10.1155/2012/313961
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Journal of Nanomaterials
Dergi Cilt Bilgisi 2012
Sayfalar -
Yayın Yılı 2012
Eser Adı
[dc.title]
5-fluorouracil encapsulated chitosan nanoparticles for pH-stimulated drug delivery: Evaluation of controlled release kinetics
Yazar
[dc.contributor.author]
Tigli Aydin R.S.
Yazar
[dc.contributor.author]
Pulat M.
Yayın Yılı
[dc.date.issued]
2012
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Nanoparticles consisting of human therapeutic drugs are suggested as a promising strategy for targeted and localized drug delivery to tumor cells. In this study, 5-fluorouracil (5-FU) encapsulated chitosan nanoparticles were prepared in order to investigate potentials of localized drug delivery for tumor environment due to pH sensitivity of chitosan nanoparticles. Optimization of chitosan and 5-FU encapsulated nanoparticles production revealed 148.8±1.1 nm and 243.1±17.9 nm particle size diameters with narrow size distributions, which are confirmed by scanning electron microscope (SEM) images. The challenge was to investigate drug delivery of 5-FU encapsulated chitosan nanoparticles due to varied pH changes. To achieve this objective, pH sensitivity of prepared chitosan nanoparticle was evaluated and results showed a significant swelling response for pH 5 with particle diameter of ~450nm. In vitro release studies indicated a controlled and sustained release of 5-FU from chitosan nanoparticles with the release amounts of 29.1-60.8% due to varied pH environments after 408 h of the incubation period. pH sensitivity is confirmed by mathematical modeling of release kinetics since chitosan nanoparticles showed stimuli-induced release. Results suggested that 5-FU encapsulated chitosan nanoparticles can be launched as pH-responsive smart drug delivery agents for possible applications of cancer treatments. © 2012 R. Seda Tl Aydn and Mehlika Pulat.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1687-4110
Dergi Adı
[dc.relation.journal]
Journal of Nanomaterials
Dergi Cilt Bilgisi
[dc.identifier.volume]
2012
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1155/2012/313961
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3860
Görüntülenme Sayısı ( Şehir )
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Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
57
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
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16 Temmuz 2024 13:55
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chitosan nanoparticles release encapsulated delivery sensitivity varied prepared investigate confirmed localized suggested showed particle incubation period Nanoparticles environments sustained controlled indicated studies amounts launched mathematical applications Mehlika treatments cancer possible modeling agents pH-responsive diameter Results
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