A controversial new approach to address hematological parameters in Hashimoto's thyroiditis

Background: Hashimoto's thyroiditis (HT) is a common autoimmune disorder. Genetic, environmental, and immunological factors all play a role in the pathogenesis of HT, but the effects of lymphocytes and platelets on the pathophysiology of HT are still unknown. In this study, we evaluated the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in HT groups and HT subgroups with low cardiovascular risks. Methods: This study included 92 patients with HT and 38 control subjects. Among the HT patients, three subgroups were formed according to thyroid function: overt (n = 12), subclinical (n = 38), and euthyroid (normally functioning thyroid; n = 42). Results: Age and gender distributions were similar between the patient and control groups. Body mass index was higher in the patient group than in the control group. The C reactive protein level was higher in patients than controls (p = 0.064). The thyroid stimulating hormone (TSH) level was higher and the mean free thyroxine level lower in the patient group than in the control group (p < 0.05). There were no differences between the groups with regard to leukocytes, neutrophils, platelets, or MPV (p > 0.05). The NLR and PLR were significantly different in one subgroup of HT patients relative to healthy subjects (p < 0.05). However, we did not find any statistical differences in the MPV among the three subgroups (p = 0.547). A positive correlation was found among the NLR, anti-thyroglobulin (TG) antibodies, and anti-thyroid peroxidase (TPO) antibodies (p < 0.01), although there was a negative correlation between the PLR, TSH, anti-TPO, and anti-TG (p < 0.001). Conclusions: A single marker or panel of biomarkers is not a consistent indicator of HT, but NLR combined with PLR testing may offer a more reliable diagnosis. © 2016, Verlag Klinisches Labor GmbH. All rights reserved.

Yazar Arpaci D.
Gürol G.
Ergenc H.
Yazar H.
Tocoglu A.G.
Ciftci I.H.
Tamer A.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3921
Tek Biçim Adres 10.7754/Clin.Lab.2015.150927
Konu Başlıkları Hashimoto's
Mean platelet volume
Neutrophil lymphocyte ratio
thyroiditis
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Clinical Laboratory
Dergi Cilt Bilgisi 62
Dergi Sayısı 7
Sayfalar 1225 - 1231
Yayın Yılı 2016
Eser Adı
[dc.title]
A controversial new approach to address hematological parameters in Hashimoto's thyroiditis
Yazar
[dc.contributor.author]
Arpaci D.
Yazar
[dc.contributor.author]
Gürol G.
Yazar
[dc.contributor.author]
Ergenc H.
Yazar
[dc.contributor.author]
Yazar H.
Yazar
[dc.contributor.author]
Tocoglu A.G.
Yazar
[dc.contributor.author]
Ciftci I.H.
Yazar
[dc.contributor.author]
Tamer A.
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
Verlag Klinisches Labor GmbH
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: Hashimoto's thyroiditis (HT) is a common autoimmune disorder. Genetic, environmental, and immunological factors all play a role in the pathogenesis of HT, but the effects of lymphocytes and platelets on the pathophysiology of HT are still unknown. In this study, we evaluated the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in HT groups and HT subgroups with low cardiovascular risks. Methods: This study included 92 patients with HT and 38 control subjects. Among the HT patients, three subgroups were formed according to thyroid function: overt (n = 12), subclinical (n = 38), and euthyroid (normally functioning thyroid; n = 42). Results: Age and gender distributions were similar between the patient and control groups. Body mass index was higher in the patient group than in the control group. The C reactive protein level was higher in patients than controls (p = 0.064). The thyroid stimulating hormone (TSH) level was higher and the mean free thyroxine level lower in the patient group than in the control group (p < 0.05). There were no differences between the groups with regard to leukocytes, neutrophils, platelets, or MPV (p > 0.05). The NLR and PLR were significantly different in one subgroup of HT patients relative to healthy subjects (p < 0.05). However, we did not find any statistical differences in the MPV among the three subgroups (p = 0.547). A positive correlation was found among the NLR, anti-thyroglobulin (TG) antibodies, and anti-thyroid peroxidase (TPO) antibodies (p < 0.01), although there was a negative correlation between the PLR, TSH, anti-TPO, and anti-TG (p < 0.001). Conclusions: A single marker or panel of biomarkers is not a consistent indicator of HT, but NLR combined with PLR testing may offer a more reliable diagnosis. © 2016, Verlag Klinisches Labor GmbH. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Hashimoto's
Konu Başlıkları
[dc.subject]
Mean platelet volume
Konu Başlıkları
[dc.subject]
Neutrophil lymphocyte ratio
Konu Başlıkları
[dc.subject]
thyroiditis
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1433-6510
İlk Sayfa Sayısı
[dc.identifier.startpage]
1225
Son Sayfa Sayısı
[dc.identifier.endpage]
1231
Dergi Adı
[dc.relation.journal]
Clinical Laboratory
Dergi Sayısı
[dc.identifier.issue]
7
Dergi Cilt Bilgisi
[dc.identifier.volume]
62
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.7754/Clin.Lab.2015.150927
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3921
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
20
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
19 Şubat 2024 18:47
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Tıklayınız
patients control groups between patient thyroid subgroups higher subjects correlation antibodies differences platelets relative statistical neutrophils significantly healthy different regard leukocytes subgroup However Background combined testing reliable diagnosis consistent Verlag Klinisches rights reserved indicator biomarkers
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