Associations of Trauma Severity with Mean Platelet Volume and Levels of Systemic Inflammatory Markers (IL1 ß, IL6, TNF ?, and CRP)

We investigated the associations of injury severity scores (ISSs) with the mean platelet volume, the serum levels of two interleukins (IL1ß and IL6), and the serum levels of tumour necrosis factor-? (TNF?) and C-reactive protein (CRP). We sought to identify biochemical parameters that could be used as components of a new biochemical parameter-based ISS system. The levels of CRP, TNF?, IL1ß, and IL6 differed significantly (all p values < 0.05) between severely injured patients and controls. The mean platelet volume (MPV) did not correlate with the ISSs (p > 0.05). The TNF? and IL6 levels were useful for determining the severity of injury, and the CRP level was elevated in all trauma patients but did not correlate with the ISS. The IL1ß level was higher in the study group but did not increase as the ISS increased. IL6 and TNF? levels were higher in the study group and increased as the ISS increased. We found no significant difference between the trauma group and healthy individuals in terms of MPV values. IL6 and TNF? levels can be used to assess trauma severity. However, neither the MPV nor the CRP or IL1ß level is useful for this purpose. © 2016 Baris Alper et al.

Yazar Alper B.
Erdogan B.
Erdogan M.Ö.
Bozan K.
Can M.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4420
Tek Biçim Adres 10.1155/2016/9894716
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Mediators of Inflammation
Dergi Cilt Bilgisi 2016
Sayfalar -
Yayın Yılı 2016
Eser Adı
[dc.title]
Associations of Trauma Severity with Mean Platelet Volume and Levels of Systemic Inflammatory Markers (IL1 ß, IL6, TNF ?, and CRP)
Yazar
[dc.contributor.author]
Alper B.
Yazar
[dc.contributor.author]
Erdogan B.
Yazar
[dc.contributor.author]
Erdogan M.Ö.
Yazar
[dc.contributor.author]
Bozan K.
Yazar
[dc.contributor.author]
Can M.
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
Hindawi Limited
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
We investigated the associations of injury severity scores (ISSs) with the mean platelet volume, the serum levels of two interleukins (IL1ß and IL6), and the serum levels of tumour necrosis factor-? (TNF?) and C-reactive protein (CRP). We sought to identify biochemical parameters that could be used as components of a new biochemical parameter-based ISS system. The levels of CRP, TNF?, IL1ß, and IL6 differed significantly (all p values < 0.05) between severely injured patients and controls. The mean platelet volume (MPV) did not correlate with the ISSs (p > 0.05). The TNF? and IL6 levels were useful for determining the severity of injury, and the CRP level was elevated in all trauma patients but did not correlate with the ISS. The IL1ß level was higher in the study group but did not increase as the ISS increased. IL6 and TNF? levels were higher in the study group and increased as the ISS increased. We found no significant difference between the trauma group and healthy individuals in terms of MPV values. IL6 and TNF? levels can be used to assess trauma severity. However, neither the MPV nor the CRP or IL1ß level is useful for this purpose. © 2016 Baris Alper et al.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0962-9351
Dergi Adı
[dc.relation.journal]
Mediators of Inflammation
Dergi Cilt Bilgisi
[dc.identifier.volume]
2016
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1155/2016/9894716
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4420
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
15
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
10 Şubat 2024 02:10
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levels increased trauma severity values higher correlate patients between injury platelet volume useful biochemical determining individuals difference significant elevated purpose healthy neither increase However assess necrosis sought protein C-reactive (TNF?) factor-? tumour parameters (IL1ß interleukins
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