Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers

Background: Cytokines appear to play a key role in some inflammatory reactions affecting the interactions among pro- and anti-inflammatory mechanisms that result in several diseases such as coal workers' pneumoconiosis (CWP). In this study, to determine the cytokine gene profiles of Turkish coal miners, we performed genotyping analysis to investigate the polymorphisms of CWP-related pro-inflammatory (TNFA, IL1A, IL1B, and IL6) and anti-inflammatory cytokines (IL-1RN and TGFB1). An additional goal was to observe whether these cytokine gene polymorphisms influence the development risk and severity of. Methods: Genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results: TNFA (-238) gene polymorphism principally affected CWP development and severity (OR = 3.47: 95% CI, 1.12-10.77 and OR = 4.30: 95% CI, 1.25-14.74, respectively) and also risk of CWP (OR = 3.79: 95% CI, 1.37-10.46). The TNFA (-308) variant was associated with a risk for the CWP severity (OR = 2.84: 95% CI, 1.08-7.39). A protective effect of IL6 was found on the development (OR = 0.48: 95% CI, 0.21-0.93) and severity of CWP (OR = 0.37: 95% CI, 0.15-0.91). Conclusions: We suggest that TNFA (-238) variant may be a risk factor in both development and the severity of CWP, while TNFA (-308) variant seems to be important only in disease severity. On the other hand, IL6 variant may have a protective effect on the development and disease severity. © 2008 Wiley-Liss, Inc.

Dergi Adı American Journal of Industrial Medicine
Dergi Cilt Bilgisi 51
Dergi Sayısı 10
Sayfalar 741 - 747
Yayın Yılı 2008
Eser Adı
[dc.title]
Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers
Yazar
[dc.contributor.author]
Ates I.
Yazar
[dc.contributor.author]
Suzen H.S.
Yazar
[dc.contributor.author]
Yucesoy B.
Yazar
[dc.contributor.author]
Tekin I.O.
Yazar
[dc.contributor.author]
Karakaya A.
Yayın Yılı
[dc.date.issued]
2008
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: Cytokines appear to play a key role in some inflammatory reactions affecting the interactions among pro- and anti-inflammatory mechanisms that result in several diseases such as coal workers' pneumoconiosis (CWP). In this study, to determine the cytokine gene profiles of Turkish coal miners, we performed genotyping analysis to investigate the polymorphisms of CWP-related pro-inflammatory (TNFA, IL1A, IL1B, and IL6) and anti-inflammatory cytokines (IL-1RN and TGFB1). An additional goal was to observe whether these cytokine gene polymorphisms influence the development risk and severity of. Methods: Genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results: TNFA (-238) gene polymorphism principally affected CWP development and severity (OR = 3.47: 95% CI, 1.12-10.77 and OR = 4.30: 95% CI, 1.25-14.74, respectively) and also risk of CWP (OR = 3.79: 95% CI, 1.37-10.46). The TNFA (-308) variant was associated with a risk for the CWP severity (OR = 2.84: 95% CI, 1.08-7.39). A protective effect of IL6 was found on the development (OR = 0.48: 95% CI, 0.21-0.93) and severity of CWP (OR = 0.37: 95% CI, 0.15-0.91). Conclusions: We suggest that TNFA (-238) variant may be a risk factor in both development and the severity of CWP, while TNFA (-308) variant seems to be important only in disease severity. On the other hand, IL6 variant may have a protective effect on the development and disease severity. © 2008 Wiley-Liss, Inc.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Coal workers' pneumoconiosis
Konu Başlıkları
[dc.subject]
Cytokine gene polymorphisms
Konu Başlıkları
[dc.subject]
Cytokines
Konu Başlıkları
[dc.subject]
Occupational exposure
Konu Başlıkları
[dc.subject]
Turkish coal workers
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0271-3586
İlk Sayfa Sayısı
[dc.identifier.startpage]
741
Son Sayfa Sayısı
[dc.identifier.endpage]
747
Dergi Adı
[dc.relation.journal]
American Journal of Industrial Medicine
Dergi Sayısı
[dc.identifier.issue]
10
Dergi Cilt Bilgisi
[dc.identifier.volume]
51
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1002/ajim.20632
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4415
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
5
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 10:40
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Tıklayınız
severity development variant polymorphism polymorphisms protective effect cytokine (-238) (-308) disease anti-inflammatory respectively) important Wiley-Liss Conclusions suggest factor associated Background reaction-restriction affected several miners Turkish profiles determine pneumoconiosis workers diseases result performed mechanisms interactions affecting
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