Colorectal carcinomas: Clinicopathologic investigation, correlation with expression of estrogen and progesterone receptors

Correlation in mortality data between breast cancer and colonic cancer, and increased incidence of colonic cancer in women with breast cancer suggest common factors in their etiology. Similarly protective effect of increasing parity from colonic cancer, and relatively better prognosis in women may imply a common role for sex steroid hormones. In this study clinicopathologic parameters as well as estrogen and progesterone receptor expressions of 60 cases of colorec-tal adenocarcinoma were investigated. Most carcinomas were moderately differentiated; stage B2 tumors were predominately located in the rectosigmoid area. Immu-nohistochemically, no nuclear staining was demonstrated for estrogen or progesterone receptors; only six displayed cytoplasmic staining with estrogen receptor. Although potential importance of estrogen and progesterone receptors has been emphasized by certain reports, its importance is still controversial in terms of both prognosis and management. Moreover, it is unclear whether to exclude cy-toplasmic staining. The significance of these receptors in colorectal carcinoma needs to be further studied.

Yazar Ekem T.E.
Bahadir B.
Gün B.D.
Bektaş S.
Kertj¸ G.
Yurdakan G.
Özdamar Ş.O.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4748
Konu Başlıkları Colorectal adenocarcinoma
Estrogen receptor
Progesterone receptor
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Turkish Journal of Cancer
Dergi Cilt Bilgisi 38
Dergi Sayısı 3
Sayfalar 118 - 122
Yayın Yılı 2008
Eser Adı
[dc.title]
Colorectal carcinomas: Clinicopathologic investigation, correlation with expression of estrogen and progesterone receptors
Yazar
[dc.contributor.author]
Ekem T.E.
Yazar
[dc.contributor.author]
Bahadir B.
Yazar
[dc.contributor.author]
Gün B.D.
Yazar
[dc.contributor.author]
Bektaş S.
Yazar
[dc.contributor.author]
Kertj¸ G.
Yazar
[dc.contributor.author]
Yurdakan G.
Yazar
[dc.contributor.author]
Özdamar Ş.O.
Yayın Yılı
[dc.date.issued]
2008
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Correlation in mortality data between breast cancer and colonic cancer, and increased incidence of colonic cancer in women with breast cancer suggest common factors in their etiology. Similarly protective effect of increasing parity from colonic cancer, and relatively better prognosis in women may imply a common role for sex steroid hormones. In this study clinicopathologic parameters as well as estrogen and progesterone receptor expressions of 60 cases of colorec-tal adenocarcinoma were investigated. Most carcinomas were moderately differentiated; stage B2 tumors were predominately located in the rectosigmoid area. Immu-nohistochemically, no nuclear staining was demonstrated for estrogen or progesterone receptors; only six displayed cytoplasmic staining with estrogen receptor. Although potential importance of estrogen and progesterone receptors has been emphasized by certain reports, its importance is still controversial in terms of both prognosis and management. Moreover, it is unclear whether to exclude cy-toplasmic staining. The significance of these receptors in colorectal carcinoma needs to be further studied.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Colorectal adenocarcinoma
Konu Başlıkları
[dc.subject]
Estrogen receptor
Konu Başlıkları
[dc.subject]
Progesterone receptor
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1019-3103
İlk Sayfa Sayısı
[dc.identifier.startpage]
118
Son Sayfa Sayısı
[dc.identifier.endpage]
122
Dergi Adı
[dc.relation.journal]
Turkish Journal of Cancer
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
38
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4748
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
286
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
16 Temmuz 2024 09:02
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Tıklayınız
cancer estrogen progesterone receptors colonic staining importance common breast prognosis receptor potential Correlation Although cytoplasmic displayed emphasized demonstrated nuclear controversial exclude studied further carcinoma colorectal significance cy-toplasmic whether certain unclear Moreover management reports Immu-nohistochemically carcinomas
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