Alterations in Plasma Essential Trace Elements Selenium, Manganese, Zinc, Copper, and Iron Concentrations and the Possible Role of these Elements on Oxidative Status in Patients with Childhood Asthma

The aim of the present study is to evaluate the status of plasma essential trace element selenium (Se), manganese (Mn), copper (Cu), zinc (Zn), and iron (Fe) concentrations and the effect of these elements on oxidative status in patients with childhood asthma. Plasma Se, Mn, Cu, and Zn concentrations were determined by atomic absorption spectrophotometry (AAS) and Fe concentrations, malondialdehyde (MDA), and total antioxidant capacity (TAC) were determined by the colorimetric method. The plasma MDA/TAC ratio was calculated as an index of oxidative status. Plasma albumin levels were measured to determine nutritional status. Plasma Fe concentrations, MDA levels and the MDA/TAC ratio were significantly higher (p<0.001, p<0.001, and p<0.01, respectively) and Se and Mn concentrations and TAC were lower (p<0.01, p<0.05, and p<0.01, respectively) in patients when compared to the healthy subjects. Plasma Zn, Cu, and albumin levels were not found to be significantly different in patients and controls (p>0.05). There were positive relationships between plasma MDA and Fe (r=0.545, p<0.001) and TAC and Se (r= 0.485, p<0.021), and a negative correlation between TAC and MDA values (r= -0.337, p<0.031) in patients with childhood asthma. However, there was no correlation between these trace elements and albumin content in patient groups. These observations suggest that increased Fe and decreased Se concentrations in patients with childhood asthma may be responsible for the oxidant/antioxidant imbalance.

Dergi Adı Biological Trace Element Research
Dergi Cilt Bilgisi 97
Dergi Sayısı 1
Sayfalar 31 - 41
Yayın Yılı 2004
Eser Adı
[dc.title]
Alterations in Plasma Essential Trace Elements Selenium, Manganese, Zinc, Copper, and Iron Concentrations and the Possible Role of these Elements on Oxidative Status in Patients with Childhood Asthma
Yazar
[dc.contributor.author]
Kocyigit A.
Yazar
[dc.contributor.author]
Armutcu F.
Yazar
[dc.contributor.author]
Gurel A.
Yazar
[dc.contributor.author]
Ermis B.
Yayın Yılı
[dc.date.issued]
2004
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The aim of the present study is to evaluate the status of plasma essential trace element selenium (Se), manganese (Mn), copper (Cu), zinc (Zn), and iron (Fe) concentrations and the effect of these elements on oxidative status in patients with childhood asthma. Plasma Se, Mn, Cu, and Zn concentrations were determined by atomic absorption spectrophotometry (AAS) and Fe concentrations, malondialdehyde (MDA), and total antioxidant capacity (TAC) were determined by the colorimetric method. The plasma MDA/TAC ratio was calculated as an index of oxidative status. Plasma albumin levels were measured to determine nutritional status. Plasma Fe concentrations, MDA levels and the MDA/TAC ratio were significantly higher (p<0.001, p<0.001, and p<0.01, respectively) and Se and Mn concentrations and TAC were lower (p<0.01, p<0.05, and p<0.01, respectively) in patients when compared to the healthy subjects. Plasma Zn, Cu, and albumin levels were not found to be significantly different in patients and controls (p>0.05). There were positive relationships between plasma MDA and Fe (r=0.545, p<0.001) and TAC and Se (r= 0.485, p<0.021), and a negative correlation between TAC and MDA values (r= -0.337, p<0.031) in patients with childhood asthma. However, there was no correlation between these trace elements and albumin content in patient groups. These observations suggest that increased Fe and decreased Se concentrations in patients with childhood asthma may be responsible for the oxidant/antioxidant imbalance.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Childhood asthma
Konu Başlıkları
[dc.subject]
Copper
Konu Başlıkları
[dc.subject]
Iron
Konu Başlıkları
[dc.subject]
Manganese
Konu Başlıkları
[dc.subject]
Oxidative status
Konu Başlıkları
[dc.subject]
Selenium
Konu Başlıkları
[dc.subject]
Zinc
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0163-4984
İlk Sayfa Sayısı
[dc.identifier.startpage]
31
Son Sayfa Sayısı
[dc.identifier.endpage]
41
Dergi Adı
[dc.relation.journal]
Biological Trace Element Research
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
97
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1385/BTER:97:1:31
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4167
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
22
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 11:51
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Tıklayınız
concentrations patients status Plasma childhood asthma between albumin levels plasma respectively) determined correlation significantly MDA/TAC elements oxidative increased positive observations suggest imbalance decreased relationships responsible oxidant/antioxidant different controls negative subjects values However groups content patient
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