Caffeic Acid Phenethyl Ester Improves Oxidative Erythrocyte Damage in a Rat Model of Thermal Injury
Oxygen-derived free radicals impair cell membrane functions and induce circulatory disturbances, and free radicals, such as superoxide anion, hydrogen peroxide, hydroxyl radicals, and peroxynitrite, have been suggested to play important roles in the pathogenesis of major burn injuries. The present study investigated the effects of thermal injury on erythrocyte lipid peroxidation and antioxidant status and investigated the effects of caffeic acid phenethyl ester (CAPE), a new antioxidant and anti-inflammatory agent, in rats subjected to thermal injury. Burn injury caused a remarkable increase in erythrocyte lipid peroxidation, levels of nitric oxide (NO), and activities of antioxidant enzymes and xanthine oxidase (XO). The treatment with CAPE decreased both activity of burn-induced XO activity and levels of NO in the erythrocytes. In conclusion, CAPE treatment resulted in decreased erythrocyte lipid peroxidation in thermal injury and helped to prevent oxidative damage by decreasing activity of XO and levels of NO.
| Yazar |
Armutcu F. Gürel A. Hoşnuter M. Pabuçcu O. Altinyazar C. |
| Yayın Türü | Article |
| Tek Biçim Adres | https://hdl.handle.net/20.500.12628/4549 |
| Tek Biçim Adres | 10.1097/01.BCR.0000111765.08625.D4 |
| Koleksiyonlar |
Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD Scopus İndeksli Yayınlar Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu |
| Dergi Adı | Journal of Burn Care and Rehabilitation |
| Dergi Cilt Bilgisi | 25 |
| Dergi Sayısı | 2 |
| Sayfalar | 171 - 178 |
| Yayın Yılı | 2004 |
| Eser Adı [dc.title] | Caffeic Acid Phenethyl Ester Improves Oxidative Erythrocyte Damage in a Rat Model of Thermal Injury |
| Yazar [dc.contributor.author] | Armutcu F. |
| Yazar [dc.contributor.author] | Gürel A. |
| Yazar [dc.contributor.author] | Hoşnuter M. |
| Yazar [dc.contributor.author] | Pabuçcu O. |
| Yazar [dc.contributor.author] | Altinyazar C. |
| Yayın Yılı [dc.date.issued] | 2004 |
| Yayın Türü [dc.type] | article |
| Özet [dc.description.abstract] | Oxygen-derived free radicals impair cell membrane functions and induce circulatory disturbances, and free radicals, such as superoxide anion, hydrogen peroxide, hydroxyl radicals, and peroxynitrite, have been suggested to play important roles in the pathogenesis of major burn injuries. The present study investigated the effects of thermal injury on erythrocyte lipid peroxidation and antioxidant status and investigated the effects of caffeic acid phenethyl ester (CAPE), a new antioxidant and anti-inflammatory agent, in rats subjected to thermal injury. Burn injury caused a remarkable increase in erythrocyte lipid peroxidation, levels of nitric oxide (NO), and activities of antioxidant enzymes and xanthine oxidase (XO). The treatment with CAPE decreased both activity of burn-induced XO activity and levels of NO in the erythrocytes. In conclusion, CAPE treatment resulted in decreased erythrocyte lipid peroxidation in thermal injury and helped to prevent oxidative damage by decreasing activity of XO and levels of NO. |
| Kayıt Giriş Tarihi [dc.date.accessioned] | 2019-12-23 |
| Açık Erişim Tarihi [dc.date.available] | 2019-12-23 |
| Yayın Dili [dc.language.iso] | eng |
| Haklar [dc.rights] | info:eu-repo/semantics/closedAccess |
| ISSN [dc.identifier.issn] | 0273-8481 |
| İlk Sayfa Sayısı [dc.identifier.startpage] | 171 |
| Son Sayfa Sayısı [dc.identifier.endpage] | 178 |
| Dergi Adı [dc.relation.journal] | Journal of Burn Care and Rehabilitation |
| Dergi Sayısı [dc.identifier.issue] | 2 |
| Dergi Cilt Bilgisi [dc.identifier.volume] | 25 |
| Tek Biçim Adres [dc.identifier.uri] | https://dx.doi.org/10.1097/01.BCR.0000111765.08625.D4 |
| Tek Biçim Adres [dc.identifier.uri] | https://hdl.handle.net/20.500.12628/4549 |
