Amiodarone has anti-inflammatory and anti-oxidative properties: An experimental study in rats with carrageenan-induced paw edema

Amiodarone is a widely used anti-arrhythmic agent. We have investigated alterations in the glutathione (GSH) level and the activities of anti-oxidative enzymes (superoxide dismutase, catalase, glutathione s-transferase and glutathione reductase) and myeloperoxidase, as marker of acute inflammation, following oral administration of amiodarone and diclofenac in rats with carrageenan-induced paw edema. In the present study, we found that 1) Amiodarone reduced the development of carrageenan-induced paw edema, to a greater degree than diclofenac; 2) Amiodarone and diclofenac alleviated increases in the activities of catalase and glutathione s-transferase enzymes resulting from edema; 3) Amiodarone and diclofenac ameliorated depressions in the GSH level and the activities of superoxide dismutase and glutathione reductase enzymes caused by carrageenan injection; and 4) All doses of amiodarone and diclofenac caused an amplification in myeloperoxidase activity resulting from induced paw edema. These results suggest that the anti-inflammatory effect of amiodarone on carrageenan-induced acute inflammation can be attributed to its ameliorating effect on the oxidative damage. © 2007 Elsevier B.V. All rights reserved.

Yazar Halici Z.
Dengiz G.O.
Odabasoglu F.
Suleyman H.
Cadirci E.
Halici M.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4174
Tek Biçim Adres 10.1016/j.ejphar.2007.03.046
Konu Başlıkları Acute inflammation
Amiodarone
Anti-oxidant enzyme
Carrageenan
Myeloperoxidase
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı European Journal of Pharmacology
Dergi Cilt Bilgisi 566
Dergi Sayısı 01.Mar
Sayfalar 215 - 221
Yayın Yılı 2007
Eser Adı
[dc.title]
Amiodarone has anti-inflammatory and anti-oxidative properties: An experimental study in rats with carrageenan-induced paw edema
Yazar
[dc.contributor.author]
Halici Z.
Yazar
[dc.contributor.author]
Dengiz G.O.
Yazar
[dc.contributor.author]
Odabasoglu F.
Yazar
[dc.contributor.author]
Suleyman H.
Yazar
[dc.contributor.author]
Cadirci E.
Yazar
[dc.contributor.author]
Halici M.
Yayın Yılı
[dc.date.issued]
2007
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Amiodarone is a widely used anti-arrhythmic agent. We have investigated alterations in the glutathione (GSH) level and the activities of anti-oxidative enzymes (superoxide dismutase, catalase, glutathione s-transferase and glutathione reductase) and myeloperoxidase, as marker of acute inflammation, following oral administration of amiodarone and diclofenac in rats with carrageenan-induced paw edema. In the present study, we found that 1) Amiodarone reduced the development of carrageenan-induced paw edema, to a greater degree than diclofenac; 2) Amiodarone and diclofenac alleviated increases in the activities of catalase and glutathione s-transferase enzymes resulting from edema; 3) Amiodarone and diclofenac ameliorated depressions in the GSH level and the activities of superoxide dismutase and glutathione reductase enzymes caused by carrageenan injection; and 4) All doses of amiodarone and diclofenac caused an amplification in myeloperoxidase activity resulting from induced paw edema. These results suggest that the anti-inflammatory effect of amiodarone on carrageenan-induced acute inflammation can be attributed to its ameliorating effect on the oxidative damage. © 2007 Elsevier B.V. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Acute inflammation
Konu Başlıkları
[dc.subject]
Amiodarone
Konu Başlıkları
[dc.subject]
Anti-oxidant enzyme
Konu Başlıkları
[dc.subject]
Carrageenan
Konu Başlıkları
[dc.subject]
Myeloperoxidase
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0014-2999
İlk Sayfa Sayısı
[dc.identifier.startpage]
215
Son Sayfa Sayısı
[dc.identifier.endpage]
221
Dergi Adı
[dc.relation.journal]
European Journal of Pharmacology
Dergi Sayısı
[dc.identifier.issue]
01.Mar
Dergi Cilt Bilgisi
[dc.identifier.volume]
566
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.ejphar.2007.03.046
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4174
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
228
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Temmuz 2024 11:16
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Tıklayınız
diclofenac glutathione Amiodarone carrageenan-induced amiodarone activities enzymes myeloperoxidase caused resulting effect inflammation s-transferase catalase dismutase injection Elsevier carrageenan amplification rights reductase superoxide reserved induced activity attributed damage results suggest oxidative anti-inflammatory ameliorating depressions reduced ameliorated
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