Anticonvulsant and hypnotic effects of amiodarone

Amiodarone hydrochloride is a potent anti-arrhythmic agent, known as a multiple ion-channel blocker in the heart. Although it has been detected in the rat brain, there are no data related to its central nervous system (CNS) effects. In this study, we evaluated anticonvulsant and hypnotic effects of amiodarone. Convulsions were induced by phentylenetetrazole (PTZ) (100 mg/kg) or caffeine (300 mg/kg) in mice. In both models, amiodarone prolonged both latency period and time to death, and acted as an anticonvulsant drug. It was found to be more effective in the PTZ model than in the caffeine model; none of the animals treated with 150 mg/kg dose amiodarone had died in the PTZ model. For hypnotic effect, sleeping was induced with pentobarbital (35 mg/kg) in rats. Amiodarone dose-dependently increased the sleeping time (677.7%~725.9%). In the sleeping test, all rats in 200 mg/kg amiodarone group died. In conclusion, anticonvulsant and hypnotic effects of amiodarone have shown the depressant effects on CNS. These effects may be dependent on its pharmacological properties. © Zhejiang University and Springer-Verlag GmbH 2009.

Dergi Adı Journal of Zhejiang University: Science B
Dergi Cilt Bilgisi 10
Dergi Sayısı 4
Sayfalar 317 - 322
Yayın Yılı 2009
Eser Adı
[dc.title]
Anticonvulsant and hypnotic effects of amiodarone
Yazar
[dc.contributor.author]
Ozbakis-Dengiz G.
Yazar
[dc.contributor.author]
Bakirci A.
Yayın Yılı
[dc.date.issued]
2009
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Amiodarone hydrochloride is a potent anti-arrhythmic agent, known as a multiple ion-channel blocker in the heart. Although it has been detected in the rat brain, there are no data related to its central nervous system (CNS) effects. In this study, we evaluated anticonvulsant and hypnotic effects of amiodarone. Convulsions were induced by phentylenetetrazole (PTZ) (100 mg/kg) or caffeine (300 mg/kg) in mice. In both models, amiodarone prolonged both latency period and time to death, and acted as an anticonvulsant drug. It was found to be more effective in the PTZ model than in the caffeine model; none of the animals treated with 150 mg/kg dose amiodarone had died in the PTZ model. For hypnotic effect, sleeping was induced with pentobarbital (35 mg/kg) in rats. Amiodarone dose-dependently increased the sleeping time (677.7%~725.9%). In the sleeping test, all rats in 200 mg/kg amiodarone group died. In conclusion, anticonvulsant and hypnotic effects of amiodarone have shown the depressant effects on CNS. These effects may be dependent on its pharmacological properties. © Zhejiang University and Springer-Verlag GmbH 2009.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Amiodarone
Konu Başlıkları
[dc.subject]
Caffeine
Konu Başlıkları
[dc.subject]
Convulsion
Konu Başlıkları
[dc.subject]
Phentylenetetrazole (PTZ)
Konu Başlıkları
[dc.subject]
Sleeping
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1673-1581
İlk Sayfa Sayısı
[dc.identifier.startpage]
317
Son Sayfa Sayısı
[dc.identifier.endpage]
322
Dergi Adı
[dc.relation.journal]
Journal of Zhejiang University: Science B
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
10
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1631/jzus.B0820316
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4303
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
16
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
04 Şubat 2024 06:18
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effects amiodarone anticonvulsant hypnotic mg/kg) sleeping induced caffeine Amiodarone University Zhejiang treated Springer-Verlag animals effective properties 7%~725 increased conclusion dose-dependently effect pentobarbital depressant dependent pharmacological prolonged related detected nervous Although blocker ion-channel multiple anti-arrhythmic potent
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