Clinical characterization of patients with macroprolactinemia and monomeric hyperprolactinemia

Macroprolactinemia is often a cause of misdiagnosis, unnecessary expensive investigation, and unsuitable treatment. The aim of the present study was to investigate the clinical findings and the concentrations of macroprolactin in patients with hyperprolactinemia in our region. Eighty-four female hyperprolactinemic patients were screened for macroprolactinemia. Prolactin was measured by chemiluminesans method on an Immulite 2000 analyzer (Siemens Health Diagnostics, Deerfield, IL, USA). Recoveries less than or equal to 40% after polyethylene glycol precipitation were indicative of macroprolactinemia. Clinical features and biochemical values were compared in true hyperprolactinemic and macroprolactinemic patients. Macroprolactinemia was detected in 31 patients (36.9%), with 84 hyperprolactinemic female patients. There was no difference in frequency of galactorrhea and oligomenorrhea/ amenorrhea between the two groups. When we evaluated the clinical features of patients according to prolactin levels, no significant difference was found between the groups. In conclusion, our initial data show that no clinical features could reliably differentiate macroprolactinemic from true hyperprolactinemic patients, but at least one of these symptoms was present in most macroprolactinemic patients. © 2011 Published by Elsevier Inc.

Yazar Can M.
Guven B.
Atmaca H.
Ackgoz S.
Mungan G.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4704
Tek Biçim Adres 10.1016/j.kjms.2010.07.002
Konu Başlıkları Galactorrhea
Hyperprolactinemia
Macroprolactinemia
Oligomenorrhea/ amenorrhea
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Kaohsiung Journal of Medical Sciences
Dergi Cilt Bilgisi 27
Dergi Sayısı 5
Sayfalar 173 - 176
Yayın Yılı 2011
Eser Adı
[dc.title]
Clinical characterization of patients with macroprolactinemia and monomeric hyperprolactinemia
Yazar
[dc.contributor.author]
Can M.
Yazar
[dc.contributor.author]
Guven B.
Yazar
[dc.contributor.author]
Atmaca H.
Yazar
[dc.contributor.author]
Ackgoz S.
Yazar
[dc.contributor.author]
Mungan G.
Yayın Yılı
[dc.date.issued]
2011
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Macroprolactinemia is often a cause of misdiagnosis, unnecessary expensive investigation, and unsuitable treatment. The aim of the present study was to investigate the clinical findings and the concentrations of macroprolactin in patients with hyperprolactinemia in our region. Eighty-four female hyperprolactinemic patients were screened for macroprolactinemia. Prolactin was measured by chemiluminesans method on an Immulite 2000 analyzer (Siemens Health Diagnostics, Deerfield, IL, USA). Recoveries less than or equal to 40% after polyethylene glycol precipitation were indicative of macroprolactinemia. Clinical features and biochemical values were compared in true hyperprolactinemic and macroprolactinemic patients. Macroprolactinemia was detected in 31 patients (36.9%), with 84 hyperprolactinemic female patients. There was no difference in frequency of galactorrhea and oligomenorrhea/ amenorrhea between the two groups. When we evaluated the clinical features of patients according to prolactin levels, no significant difference was found between the groups. In conclusion, our initial data show that no clinical features could reliably differentiate macroprolactinemic from true hyperprolactinemic patients, but at least one of these symptoms was present in most macroprolactinemic patients. © 2011 Published by Elsevier Inc.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Galactorrhea
Konu Başlıkları
[dc.subject]
Hyperprolactinemia
Konu Başlıkları
[dc.subject]
Macroprolactinemia
Konu Başlıkları
[dc.subject]
Oligomenorrhea/ amenorrhea
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1607551X
İlk Sayfa Sayısı
[dc.identifier.startpage]
173
Son Sayfa Sayısı
[dc.identifier.endpage]
176
Dergi Adı
[dc.relation.journal]
Kaohsiung Journal of Medical Sciences
Dergi Sayısı
[dc.identifier.issue]
5
Dergi Cilt Bilgisi
[dc.identifier.volume]
27
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.kjms.2010.07.002
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4704
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
17
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
14 Şubat 2024 06:59
Google Kontrol
Tıklayınız
patients hyperprolactinemic macroprolactinemic clinical features Macroprolactinemia difference between groups macroprolactinemia female present reliably Elsevier amenorrhea oligomenorrhea/ galactorrhea frequency detected compared evaluated values differentiate Published according initial conclusion symptoms significant levels prolactin biochemical screened Eighty-four region
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms