Clinical and cognitive profiles of patients with both Parkinson's disease and essential tremor

Although Parkinson's disease (PD) and essential tremor (ET) are distinct clinical disorders, their coexistence can sometimes cause diagnostic problems. In this study, we conducted detailed investigations of patients with both ET and PD (ET-PD) and compared their clinical and cognitive profiles with those of patients with only ET or only PD. This study examined three groups of patients: the first group had ET-PD concomitantly (n = 9); the second group had only ET (n = 9); the third group had only PD (n = 10). The groups were compared in terms of demographic characteristics, clinical features, and cognitive functions. With the exception of positive family histories, which were more common in ET-PD than in PD patients, we found no differences among the groups with respect to demographic characteristics (p = 0.044). PD-only patients had more akinetic-rigid type Parkinsonism (p = 0.016), and their levodopa response was better than that of ET-PD patients (p = 0.017). Patients with ET-PD obtained significantly lower scores than those with pure ET on several cognitive tests, suggesting a prominent frontal-type cognitive dysfunction. In conclusion ET-PD patients differed from PD patients, showing more frequent familial tremor histories and lower levodopa responsiveness. This patient population also demonstrated more severe cognitive impairments than pure-ET patients. This result suggests that ET-PD patients are a subset of ET patients with more widespread neurodegeneration, which may indicate the presence of a syndrome that includes overlap between ET and PD. © 2012 Belgian Neurological Society.

Yazar Ozen Barut B.
Gunal D.I.
Turkmen Ç.
Mollahasanoglu A.
Ankarali H.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4698
Tek Biçim Adres 10.1007/s13760-012-0124-z
Konu Başlıkları Cognition
Essential tremor
Parkinson's disease
Tremor
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Acta Neurologica Belgica
Dergi Cilt Bilgisi 113
Dergi Sayısı 2
Sayfalar 117 - 125
Yayın Yılı 2013
Eser Adı
[dc.title]
Clinical and cognitive profiles of patients with both Parkinson's disease and essential tremor
Yazar
[dc.contributor.author]
Ozen Barut B.
Yazar
[dc.contributor.author]
Gunal D.I.
Yazar
[dc.contributor.author]
Turkmen Ç.
Yazar
[dc.contributor.author]
Mollahasanoglu A.
Yazar
[dc.contributor.author]
Ankarali H.
Yayın Yılı
[dc.date.issued]
2013
Yayıncı
[dc.publisher]
Springer-Verlag Italia s.r.l.
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Although Parkinson's disease (PD) and essential tremor (ET) are distinct clinical disorders, their coexistence can sometimes cause diagnostic problems. In this study, we conducted detailed investigations of patients with both ET and PD (ET-PD) and compared their clinical and cognitive profiles with those of patients with only ET or only PD. This study examined three groups of patients: the first group had ET-PD concomitantly (n = 9); the second group had only ET (n = 9); the third group had only PD (n = 10). The groups were compared in terms of demographic characteristics, clinical features, and cognitive functions. With the exception of positive family histories, which were more common in ET-PD than in PD patients, we found no differences among the groups with respect to demographic characteristics (p = 0.044). PD-only patients had more akinetic-rigid type Parkinsonism (p = 0.016), and their levodopa response was better than that of ET-PD patients (p = 0.017). Patients with ET-PD obtained significantly lower scores than those with pure ET on several cognitive tests, suggesting a prominent frontal-type cognitive dysfunction. In conclusion ET-PD patients differed from PD patients, showing more frequent familial tremor histories and lower levodopa responsiveness. This patient population also demonstrated more severe cognitive impairments than pure-ET patients. This result suggests that ET-PD patients are a subset of ET patients with more widespread neurodegeneration, which may indicate the presence of a syndrome that includes overlap between ET and PD. © 2012 Belgian Neurological Society.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Cognition
Konu Başlıkları
[dc.subject]
Essential tremor
Konu Başlıkları
[dc.subject]
Parkinson's disease
Konu Başlıkları
[dc.subject]
Tremor
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0300-9009
İlk Sayfa Sayısı
[dc.identifier.startpage]
117
Son Sayfa Sayısı
[dc.identifier.endpage]
125
Dergi Adı
[dc.relation.journal]
Acta Neurologica Belgica
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
113
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s13760-012-0124-z
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4698
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
10
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 07:33
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Tıklayınız
patients cognitive groups clinical demographic characteristics levodopa histories compared tremor prominent between suggesting several scores dysfunction significantly obtained Belgian Neurological Patients Society better frontal-type includes conclusion responsiveness severe pure-ET result demonstrated suggests population subset patient
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