Caffeic acid phenethyl ester improves oxidative organ damage in rat model of thermal trauma

Severe burn injuries cause functional impairment in distant internal organs. Although this mechanism is not clear, it is possible that free radical toxicity plays an important role. Research in animals and clinical studies have shown that there is a close relationship between a lipid peroxidative reaction and secondary pathological changes following thermal injury. It has been demonstrated that antioxidant treatment prevents oxidative tissue damage associated with thermal trauma. This study was designed to determine the possible protective effect of caffeic acid phenethyl ester (CAPE) treatment against oxidative damage in the kidney and lung induced by thermal injury. Rats were decapitated either 1, 3 or 7 days after burn injury. CAPE was administered intraperitoneally immediately after thermal injury. Kidney and lung tissues were taken for the determination of malondialdehyde (MDA) level, myeloperoxidase (MPO), catalase (CAT), Superoxide dismutase (SOD) and xanthine oxidase (XO) activities. Severe skin thermal injury caused a significant decrease in SOD and CAT activities, as well as significant increases in MDA level, XO and MPO activities in tissues during the postburn period. Treatment of rats with CAPE (10 µmol/kg) significantly elevated the decreased SOD and CAT activities, while it decreased MDA levels and MPO as well as XO activity.

Dergi Adı Physiological Research
Dergi Cilt Bilgisi 53
Dergi Sayısı 6
Sayfalar 675 - 682
Yayın Yılı 2004
Eser Adı
[dc.title]
Caffeic acid phenethyl ester improves oxidative organ damage in rat model of thermal trauma
Yazar
[dc.contributor.author]
Gurel A.
Yazar
[dc.contributor.author]
Armutcu F.
Yazar
[dc.contributor.author]
Hosnuter M.
Yazar
[dc.contributor.author]
Unalacak M.
Yazar
[dc.contributor.author]
Kargi E.
Yazar
[dc.contributor.author]
Altinyazar C.
Yayın Yılı
[dc.date.issued]
2004
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Severe burn injuries cause functional impairment in distant internal organs. Although this mechanism is not clear, it is possible that free radical toxicity plays an important role. Research in animals and clinical studies have shown that there is a close relationship between a lipid peroxidative reaction and secondary pathological changes following thermal injury. It has been demonstrated that antioxidant treatment prevents oxidative tissue damage associated with thermal trauma. This study was designed to determine the possible protective effect of caffeic acid phenethyl ester (CAPE) treatment against oxidative damage in the kidney and lung induced by thermal injury. Rats were decapitated either 1, 3 or 7 days after burn injury. CAPE was administered intraperitoneally immediately after thermal injury. Kidney and lung tissues were taken for the determination of malondialdehyde (MDA) level, myeloperoxidase (MPO), catalase (CAT), Superoxide dismutase (SOD) and xanthine oxidase (XO) activities. Severe skin thermal injury caused a significant decrease in SOD and CAT activities, as well as significant increases in MDA level, XO and MPO activities in tissues during the postburn period. Treatment of rats with CAPE (10 µmol/kg) significantly elevated the decreased SOD and CAT activities, while it decreased MDA levels and MPO as well as XO activity.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Burn
Konu Başlıkları
[dc.subject]
CAPE
Konu Başlıkları
[dc.subject]
Honeybee extracts
Konu Başlıkları
[dc.subject]
Kidney
Konu Başlıkları
[dc.subject]
Lung
Konu Başlıkları
[dc.subject]
Oxidative damage
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0862-8408
İlk Sayfa Sayısı
[dc.identifier.startpage]
675
Son Sayfa Sayısı
[dc.identifier.endpage]
682
Dergi Adı
[dc.relation.journal]
Physiological Research
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
53
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4550
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
20
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 07:29
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Tıklayınız
thermal injury activities significant decreased treatment oxidative damage tissues Severe possible oxidase xanthine dismutase Superoxide catalase myeloperoxidase malondialdehyde mechanism determination Kidney immediately intraperitoneally administered period activity levels injuries elevated significantly µmol/kg) Treatment postburn caused during
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