Outcome of cystic hygroma in fetuses with normal karyotypes depends on associated findings

Objective: To determine the associated diagnostic findings which are linked with adverse fetal outcome in nuchal cystic hygroma. Study design: Based on a series of 32 cases, we determined the sonographic morphology of the hygroma, associated structural anomalies, karyotypes and autopsy findings. Intrauterine fetal death, spontaneous abortion and abnormal karyotypes were assigned as adverse outcome parameters. Results: The mean gestational age at diagnosis was 14.4 weeks (range 10-21). There were 18 nonseptated and 14 septated hygromas. Besides hygroma, associated sonographic detectable structural anomalies were observed in 17 cases (53.1%). The greatest number of associated sonographic anomalies were hydrops (31.3%), generalised skin oedema (6.3%) and pterygium colli (6.3%). Cytogenetic analysis revealed an abnormal karyotype in 13 of 26 (50%) invasive procedures. Turner syndrome and Trisomy 18 (both 15.4%) were the most frequent cytogenetic abnormalities. Autopsy was performed in 24 cases and 16 cases (66.7%) had an associated autopsy finding to hygroma colli. The most frequent associated autopsy findings were limb and craniofacial anomalies (both 25%). Only 3 (9.4%) mothers gave birth to healthy newborns. The overall fetal adverse outcome rate was 68.8% (22 cases). Conclusions: Fetuses with NCH are at high risk for adverse outcome and detailed prenatal diagnosis including invasive procedures should be offered. According to the presented autopsy findings, to determine fetal outcome in NCH cases with normal karyotypes, detailed sonography should be concentrated beside the exclusion of fetal heart defects and existence of hydrops fetalis, on the skeletal, urogenital and craniofacial anomalies, as these might cause severe morbidity. © 2004 Elsevier Ireland Ltd. All rights reserved.

Yazar Tanriverdi H.A.
Ertan A.K.
Hendrik H.J.
Remberger K.
Schmidt W.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/6890
Tek Biçim Adres 10.1016/j.ejogrb.2004.04.005
Konu Başlıkları Associated antenatal findings
Fetal outcome
Hygroma colli
Prenatal diagnosis
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı European Journal of Obstetrics and Gynecology and Reproductive Biology
Dergi Cilt Bilgisi 118
Dergi Sayısı 1
Sayfalar 40 - 46
Yayın Yılı 2005
Eser Adı
[dc.title]
Outcome of cystic hygroma in fetuses with normal karyotypes depends on associated findings
Yazar
[dc.contributor.author]
Tanriverdi H.A.
Yazar
[dc.contributor.author]
Ertan A.K.
Yazar
[dc.contributor.author]
Hendrik H.J.
Yazar
[dc.contributor.author]
Remberger K.
Yazar
[dc.contributor.author]
Schmidt W.
Yayın Yılı
[dc.date.issued]
2005
Yayıncı
[dc.publisher]
Elsevier Ireland Ltd
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: To determine the associated diagnostic findings which are linked with adverse fetal outcome in nuchal cystic hygroma. Study design: Based on a series of 32 cases, we determined the sonographic morphology of the hygroma, associated structural anomalies, karyotypes and autopsy findings. Intrauterine fetal death, spontaneous abortion and abnormal karyotypes were assigned as adverse outcome parameters. Results: The mean gestational age at diagnosis was 14.4 weeks (range 10-21). There were 18 nonseptated and 14 septated hygromas. Besides hygroma, associated sonographic detectable structural anomalies were observed in 17 cases (53.1%). The greatest number of associated sonographic anomalies were hydrops (31.3%), generalised skin oedema (6.3%) and pterygium colli (6.3%). Cytogenetic analysis revealed an abnormal karyotype in 13 of 26 (50%) invasive procedures. Turner syndrome and Trisomy 18 (both 15.4%) were the most frequent cytogenetic abnormalities. Autopsy was performed in 24 cases and 16 cases (66.7%) had an associated autopsy finding to hygroma colli. The most frequent associated autopsy findings were limb and craniofacial anomalies (both 25%). Only 3 (9.4%) mothers gave birth to healthy newborns. The overall fetal adverse outcome rate was 68.8% (22 cases). Conclusions: Fetuses with NCH are at high risk for adverse outcome and detailed prenatal diagnosis including invasive procedures should be offered. According to the presented autopsy findings, to determine fetal outcome in NCH cases with normal karyotypes, detailed sonography should be concentrated beside the exclusion of fetal heart defects and existence of hydrops fetalis, on the skeletal, urogenital and craniofacial anomalies, as these might cause severe morbidity. © 2004 Elsevier Ireland Ltd. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Associated antenatal findings
Konu Başlıkları
[dc.subject]
Fetal outcome
Konu Başlıkları
[dc.subject]
Hygroma colli
Konu Başlıkları
[dc.subject]
Prenatal diagnosis
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0301-2115
İlk Sayfa Sayısı
[dc.identifier.startpage]
40
Son Sayfa Sayısı
[dc.identifier.endpage]
46
Dergi Adı
[dc.relation.journal]
European Journal of Obstetrics and Gynecology and Reproductive Biology
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
118
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.ejogrb.2004.04.005
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6890
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
16
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 00:23
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Tıklayınız
associated outcome anomalies hygroma autopsy findings adverse sonographic karyotypes diagnosis should hydrops abnormal detailed structural frequent craniofacial determine procedures invasive finding cases) Conclusions newborns healthy mothers overall Objective Fetuses urogenital severe morbidity fetalis Elsevier Ireland
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