Stereological evaluation of local administered palmatine on bone regeneration [Lokal olarak uygulanan palmatinin kemik rejenerasyonuna etkisinin stereolojik olarak incelenmesi]

Aim: The purpose of this study is to investigate the healing potential of the local administration of palmatine on autogenous grafted critical-sized cortical bone defects. Material and Method: Twenty-four rats were divided into three groups: Group C (passive control), Group G (active control) and Group G+PLM. A 5-mm diameter critical-size defect was created in the calvarium of each animal. In Group C, the defects were left empty. In Group G defects were filled with only autogenous graft and an absorbable collagen sponge treated with 300 mg sterile saline solution was applied on grafted area. In Group G+PLM defects were filled with autogenous graft, and 300 mg palmatine treated absorbable collagen sponge was applied on grafted area. All animals were euthanized at 28 days postoperative. Stereologic analyses were performed. New bone volume and connective tissue volumes were measured. Results: Stereologic analysis showed that Group G and G+PLM significantly had more new bone at four weeks compared with group C. Connective tissue volumes were also significantly higher in autografted groups. New bone and connective tissue volumes’ difference were not statistically significant between group G and G+PLM groups. Discussion: Locally administered 500 mg palmatine doesn’t enhance bone regeneration in critical size calvarial rat defects filled with autologous graft. © 2017, Derman Medical Publishing. All rights reserved.

Yazar Türer Ç.C.
Türer A.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7637
Tek Biçim Adres 10.4328/JCAM.5213
Konu Başlıkları Bone regeneration
Palmatine
Rat
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Journal of Clinical and Analytical Medicine
Dergi Cilt Bilgisi 8
Dergi Sayısı 6
Sayfalar 478 - 481
Yayın Yılı 2017
Eser Adı
[dc.title]
Stereological evaluation of local administered palmatine on bone regeneration [Lokal olarak uygulanan palmatinin kemik rejenerasyonuna etkisinin stereolojik olarak incelenmesi]
Yazar
[dc.contributor.author]
Türer Ç.C.
Yazar
[dc.contributor.author]
Türer A.
Yayın Yılı
[dc.date.issued]
2017
Yayıncı
[dc.publisher]
Derman Medical Publishing
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Aim: The purpose of this study is to investigate the healing potential of the local administration of palmatine on autogenous grafted critical-sized cortical bone defects. Material and Method: Twenty-four rats were divided into three groups: Group C (passive control), Group G (active control) and Group G+PLM. A 5-mm diameter critical-size defect was created in the calvarium of each animal. In Group C, the defects were left empty. In Group G defects were filled with only autogenous graft and an absorbable collagen sponge treated with 300 mg sterile saline solution was applied on grafted area. In Group G+PLM defects were filled with autogenous graft, and 300 mg palmatine treated absorbable collagen sponge was applied on grafted area. All animals were euthanized at 28 days postoperative. Stereologic analyses were performed. New bone volume and connective tissue volumes were measured. Results: Stereologic analysis showed that Group G and G+PLM significantly had more new bone at four weeks compared with group C. Connective tissue volumes were also significantly higher in autografted groups. New bone and connective tissue volumes’ difference were not statistically significant between group G and G+PLM groups. Discussion: Locally administered 500 mg palmatine doesn’t enhance bone regeneration in critical size calvarial rat defects filled with autologous graft. © 2017, Derman Medical Publishing. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Bone regeneration
Konu Başlıkları
[dc.subject]
Palmatine
Konu Başlıkları
[dc.subject]
Rat
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1309-0720
İlk Sayfa Sayısı
[dc.identifier.startpage]
478
Son Sayfa Sayısı
[dc.identifier.endpage]
481
Dergi Adı
[dc.relation.journal]
Journal of Clinical and Analytical Medicine
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
8
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.4328/JCAM.5213
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7637
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
8
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 06:14
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Tıklayınız
defects filled groups grafted autogenous palmatine tissue Stereologic volumes applied collagen significantly treated absorbable sponge connective control) statistically calvarial autologous Derman showed analysis Medical Results measured Publishing rights reserved critical enhance regeneration Connective difference volumes’
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