Relationship of fetuin - A with restenosis in patients who underwent revascularization

We investigated whether fetuin-A (a hepatic secretory protein that prevents arterial calcification) was related to revascularization in patients who had previously undergone coronary revascularization (percutaneous coronary intervention and/or coronary artery bypass grafting operation). Methods: This study included 71 patients who had previously undergone any revascularization procedure. All patients presented to the cardiology outpatient clinic with angina or angina equivalent and underwent coronary angiography upon findings of preliminary tests. The patients were grouped on the basis of the presence of restenosis on angiography: Group 1 consisted of 44 subjects with restenosis on angiography (30 male, 14 female; mean age 64.2±4.2 years) and group 2; 30 subjects without restenosis on angiography (20 male, 10 female; 61.2±13.1 years). In addition to routine biochemical tests and lipid panel, all patients underwent C-reactive protein, and fetuin-A measurements. Results: The groups were not significantly different with respect to age, sex, systolic and diastolic blood pressure. As compared to Group 2, Group 1 had a significantly lower fetuin-A level (383.8±76.2 vs. 416.3±49.3 ng/mL; p=0.029). There was a significantly negative correlation between fetuin-A and age; and a significantly positive correlation between fetuin-A and calcium. Conclusions: Fetuin-A levels were significantly lower in patients detected to have restenosis. Lower fetuin-A levels may contribute to restenosis by directly increasing calcium-phosphate precipitation. © 2016 by De Gruyter.

Yazar Karabag T.
Kucuk E.
Tekin I.O.
Sayin M.R.
Gursoy Y.C.
Aydin M.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7366
Tek Biçim Adres 10.1515/labmed-2015-0065
Konu Başlıkları Calcification
fetuin-A
inflammation
restenosis
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı LaboratoriumsMedizin
Dergi Cilt Bilgisi 40
Dergi Sayısı 1
Sayfalar 43 - 48
Yayın Yılı 2016
Eser Adı
[dc.title]
Relationship of fetuin - A with restenosis in patients who underwent revascularization
Yazar
[dc.contributor.author]
Karabag T.
Yazar
[dc.contributor.author]
Kucuk E.
Yazar
[dc.contributor.author]
Tekin I.O.
Yazar
[dc.contributor.author]
Sayin M.R.
Yazar
[dc.contributor.author]
Gursoy Y.C.
Yazar
[dc.contributor.author]
Aydin M.
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
Walter de Gruyter GmbH
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
We investigated whether fetuin-A (a hepatic secretory protein that prevents arterial calcification) was related to revascularization in patients who had previously undergone coronary revascularization (percutaneous coronary intervention and/or coronary artery bypass grafting operation). Methods: This study included 71 patients who had previously undergone any revascularization procedure. All patients presented to the cardiology outpatient clinic with angina or angina equivalent and underwent coronary angiography upon findings of preliminary tests. The patients were grouped on the basis of the presence of restenosis on angiography: Group 1 consisted of 44 subjects with restenosis on angiography (30 male, 14 female; mean age 64.2±4.2 years) and group 2; 30 subjects without restenosis on angiography (20 male, 10 female; 61.2±13.1 years). In addition to routine biochemical tests and lipid panel, all patients underwent C-reactive protein, and fetuin-A measurements. Results: The groups were not significantly different with respect to age, sex, systolic and diastolic blood pressure. As compared to Group 2, Group 1 had a significantly lower fetuin-A level (383.8±76.2 vs. 416.3±49.3 ng/mL; p=0.029). There was a significantly negative correlation between fetuin-A and age; and a significantly positive correlation between fetuin-A and calcium. Conclusions: Fetuin-A levels were significantly lower in patients detected to have restenosis. Lower fetuin-A levels may contribute to restenosis by directly increasing calcium-phosphate precipitation. © 2016 by De Gruyter.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Calcification
Konu Başlıkları
[dc.subject]
fetuin-A
Konu Başlıkları
[dc.subject]
inflammation
Konu Başlıkları
[dc.subject]
restenosis
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0342-3026
İlk Sayfa Sayısı
[dc.identifier.startpage]
43
Son Sayfa Sayısı
[dc.identifier.endpage]
48
Dergi Adı
[dc.relation.journal]
LaboratoriumsMedizin
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
40
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1515/labmed-2015-0065
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7366
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
19
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
10 Şubat 2024 05:53
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patients fetuin-A restenosis significantly angiography coronary revascularization between correlation female subjects angina underwent levels undergone protein previously years) pressure Results C-reactive measurements diastolic groups compared respect systolic different detected Gruyter precipitation calcium-phosphate increasing directly contribute
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