Oxidative stress and apoptosis in preeclampsia

We aimed to determine the oxidative stress and antioxidant status in preeclamptic placenta. Also, we investigated the apoptotic index of villous trophoblast and proliferation index of cytotrophoblasts. The study included 32 pregnant with preeclampsia and 31 normotensive healthy pregnant women. Malondialdehyde (MDA) and total antioxidant status (TAS) levels were measured in the placenta. For detection of apoptosis and proliferation in trophoblast, apoptosis protease activating factor 1 (APAF-1) and Ki-67 were used. Placental MDA levels in preeclamptic women were significantly higher than normal pregnancies (. p=. 0.002). There was no significant difference between the groups in the TAS levels of placenta (. p=. 0.773). Also, the apoptotic index in villous trophoblasts increased (. p<. 0.001), but proliferation index did not change in preeclampsia (. p=. 0.850). Increased oxidative stress and apoptosis in pathological placenta are not balanced by antioxidant systems and proliferation mechanisms. © 2014 Elsevier Ltd.

Yazar Can M.
Guven B.
Bektas S.
Arikan I.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/6902
Tek Biçim Adres 10.1016/j.tice.2014.08.004
Konu Başlıkları APAF-1
Ki-67
Oxidative stress
Preeclampsia
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Tissue and Cell
Dergi Cilt Bilgisi 46
Dergi Sayısı 6
Sayfalar 477 - 481
Yayın Yılı 2014
Eser Adı
[dc.title]
Oxidative stress and apoptosis in preeclampsia
Yazar
[dc.contributor.author]
Can M.
Yazar
[dc.contributor.author]
Guven B.
Yazar
[dc.contributor.author]
Bektas S.
Yazar
[dc.contributor.author]
Arikan I.
Yayın Yılı
[dc.date.issued]
2014
Yayıncı
[dc.publisher]
Churchill Livingstone
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
We aimed to determine the oxidative stress and antioxidant status in preeclamptic placenta. Also, we investigated the apoptotic index of villous trophoblast and proliferation index of cytotrophoblasts. The study included 32 pregnant with preeclampsia and 31 normotensive healthy pregnant women. Malondialdehyde (MDA) and total antioxidant status (TAS) levels were measured in the placenta. For detection of apoptosis and proliferation in trophoblast, apoptosis protease activating factor 1 (APAF-1) and Ki-67 were used. Placental MDA levels in preeclamptic women were significantly higher than normal pregnancies (. p=. 0.002). There was no significant difference between the groups in the TAS levels of placenta (. p=. 0.773). Also, the apoptotic index in villous trophoblasts increased (. p<. 0.001), but proliferation index did not change in preeclampsia (. p=. 0.850). Increased oxidative stress and apoptosis in pathological placenta are not balanced by antioxidant systems and proliferation mechanisms. © 2014 Elsevier Ltd.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
APAF-1
Konu Başlıkları
[dc.subject]
Ki-67
Konu Başlıkları
[dc.subject]
Oxidative stress
Konu Başlıkları
[dc.subject]
Preeclampsia
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0040-8166
İlk Sayfa Sayısı
[dc.identifier.startpage]
477
Son Sayfa Sayısı
[dc.identifier.endpage]
481
Dergi Adı
[dc.relation.journal]
Tissue and Cell
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
46
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.tice.2014.08.004
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6902
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
17
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 05:59
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Tıklayınız
proliferation placenta antioxidant levels apoptosis preeclampsia trophoblast pregnant villous preeclamptic stress apoptotic status oxidative significant difference between increased groups Elsevier trophoblasts change Increased pathological balanced systems mechanisms activating pregnancies included Malondialdehyde healthy normotensive cytotrophoblasts investigated
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

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