Study of DNA-Binding Activity and Antibacterial Effect of Escitalopram Oxalate, an Extensively Prescribed Antidepressant

Escitalopram oxalate (EO) is considered as one of the extensively prescribed antidepressant drug in Turkey and some other countries, therefore this research was aimed to study the interaction of the drug with DNA and study of the substance effect on bacterial growth. The absorption value of the drug solution at 238 nm was increased when DNA was added gradually to it and it showed hyperchromism effect. The value obtained for DNA binding constant (Kb) was 0.035 M -1. When we added the CuCl2 2H2O to the mixture, any breakage was not shown in double strand DNA in comparison with control DNA. In addition low concentration of EO couldn't protect DNA (0.5273 µmole bp) against Hydroxyl free radical (0.12 µmole) although it could protect the DNA when it was at the same or higher concentrations (0.5273, 5.273 and 252.73 µmole) than the DNA concentration. In addition, MIC of the drug for E.coli and Bacillus subtilis was almost 0.185 mM and 0.55 mM respectively. The E.coli strain was killed at concentrations 45, 15, 5 mM while the Bacillus subtilis was stable against all of the concentrations. © Georg Thieme Verlag KG Stuttgart New York.

Yazar Valipour R.
Yilmaz M.B.
Valipour E.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7674
Tek Biçim Adres 10.1055/a-0809-5044
Konu Başlıkları antibacteria
antidepressant
breakage
DNA
escitalopram
MIC
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Drug Research
Dergi Cilt Bilgisi 69
Dergi Sayısı 10
Sayfalar 545 - 550
Yayın Yılı 2019
Eser Adı
[dc.title]
Study of DNA-Binding Activity and Antibacterial Effect of Escitalopram Oxalate, an Extensively Prescribed Antidepressant
Yazar
[dc.contributor.author]
Valipour R.
Yazar
[dc.contributor.author]
Yilmaz M.B.
Yazar
[dc.contributor.author]
Valipour E.
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
Georg Thieme Verlag
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Escitalopram oxalate (EO) is considered as one of the extensively prescribed antidepressant drug in Turkey and some other countries, therefore this research was aimed to study the interaction of the drug with DNA and study of the substance effect on bacterial growth. The absorption value of the drug solution at 238 nm was increased when DNA was added gradually to it and it showed hyperchromism effect. The value obtained for DNA binding constant (Kb) was 0.035 M -1. When we added the CuCl2 2H2O to the mixture, any breakage was not shown in double strand DNA in comparison with control DNA. In addition low concentration of EO couldn't protect DNA (0.5273 µmole bp) against Hydroxyl free radical (0.12 µmole) although it could protect the DNA when it was at the same or higher concentrations (0.5273, 5.273 and 252.73 µmole) than the DNA concentration. In addition, MIC of the drug for E.coli and Bacillus subtilis was almost 0.185 mM and 0.55 mM respectively. The E.coli strain was killed at concentrations 45, 15, 5 mM while the Bacillus subtilis was stable against all of the concentrations. © Georg Thieme Verlag KG Stuttgart New York.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
antibacteria
Konu Başlıkları
[dc.subject]
antidepressant
Konu Başlıkları
[dc.subject]
breakage
Konu Başlıkları
[dc.subject]
DNA
Konu Başlıkları
[dc.subject]
escitalopram
Konu Başlıkları
[dc.subject]
MIC
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
2194-9379
Sponsor YAYINCI
[dc.description.sponsorship]
UGC-DAE Consortium for Scientific Research, University Grants Commission: FYL-2017–9464
Sponsor YAYINCI
[dc.description.sponsorship]
We wish to thank the Cukurova University Scientific Research Commission for supporting our research through project grants no FYL-2017–9464
İlk Sayfa Sayısı
[dc.identifier.startpage]
545
Son Sayfa Sayısı
[dc.identifier.endpage]
550
Dergi Adı
[dc.relation.journal]
Drug Research
Dergi Sayısı
[dc.identifier.issue]
10
Dergi Cilt Bilgisi
[dc.identifier.volume]
69
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1055/a-0809-5044
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7674
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
4
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
28 Ocak 2024 22:42
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Tıklayınız
concentrations concentration Bacillus subtilis effect protect µmole) addition against couldn higher µmole Hydroxyl radical although Escitalopram Stuttgart Verlag Thieme stable killed strain respectively almost countries absorption growth bacterial substance interaction research therefore Turkey antidepressant prescribed
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