Salinomycin encapsulated nanoparticles as a targeting vehicle for glioblastoma cells

Salinomycin has been introduced as a novel alternative to traditional anti-cancer drugs. The aim of this study was to test a strategy designed to deliver salinomycin to glioblastoma cells in vitro. Salinomycin-encapsulated polysorbate 80-coated poly(lactic-co-glycolic acid) nanoparticles (P80-SAL-PLGA) were prepared and characterized with respect to particle size, morphology, thermal properties, drug encapsulation efficiency and controlled salinomycin-release behaviour. The in vitro cellular uptake of P80-SAL-PLGA (5 and 10 µM) or uncoated nanoparticles was assessed in T98G human glioblastoma cells, and the cell viability was investigated with respect to anti-growth activities. SAL, which was successfully transported to T98G glioblastoma cells via P80 coated nanoparticles (~14% within 60 min), greatly decreased (p < 0.01) the cellular viability of T98G cells. Substantial morphological changes were observed in the T98G cells with damaged actin cytoskeleton. Thus, P80-SAL-PLGA nanoparticles induced cell death, suggesting a potential therapeutic role for this salinomycin delivery system in the treatment of human glioblastoma. © 2015 Wiley Periodicals, Inc.

Yazar Ti?li Aydin R.S.
Kaynak G.
Gümüşderelio?lu M.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7461
Tek Biçim Adres 10.1002/jbm.a.35591
Konu Başlıkları glioblastoma
nanoparticle
PLGA
polysorbate 80
salinomycin
targeting
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
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Dergi Adı Journal of Biomedical Materials Research - Part A
Dergi Cilt Bilgisi 104
Dergi Sayısı 2
Sayfalar 455 - 464
Yayın Yılı 2016
Eser Adı
[dc.title]
Salinomycin encapsulated nanoparticles as a targeting vehicle for glioblastoma cells
Yazar
[dc.contributor.author]
Ti?li Aydin R.S.
Yazar
[dc.contributor.author]
Kaynak G.
Yazar
[dc.contributor.author]
Gümüşderelio?lu M.
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
John Wiley and Sons Inc.
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Salinomycin has been introduced as a novel alternative to traditional anti-cancer drugs. The aim of this study was to test a strategy designed to deliver salinomycin to glioblastoma cells in vitro. Salinomycin-encapsulated polysorbate 80-coated poly(lactic-co-glycolic acid) nanoparticles (P80-SAL-PLGA) were prepared and characterized with respect to particle size, morphology, thermal properties, drug encapsulation efficiency and controlled salinomycin-release behaviour. The in vitro cellular uptake of P80-SAL-PLGA (5 and 10 µM) or uncoated nanoparticles was assessed in T98G human glioblastoma cells, and the cell viability was investigated with respect to anti-growth activities. SAL, which was successfully transported to T98G glioblastoma cells via P80 coated nanoparticles (~14% within 60 min), greatly decreased (p < 0.01) the cellular viability of T98G cells. Substantial morphological changes were observed in the T98G cells with damaged actin cytoskeleton. Thus, P80-SAL-PLGA nanoparticles induced cell death, suggesting a potential therapeutic role for this salinomycin delivery system in the treatment of human glioblastoma. © 2015 Wiley Periodicals, Inc.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
glioblastoma
Konu Başlıkları
[dc.subject]
nanoparticle
Konu Başlıkları
[dc.subject]
PLGA
Konu Başlıkları
[dc.subject]
polysorbate 80
Konu Başlıkları
[dc.subject]
salinomycin
Konu Başlıkları
[dc.subject]
targeting
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1549-3296
İlk Sayfa Sayısı
[dc.identifier.startpage]
455
Son Sayfa Sayısı
[dc.identifier.endpage]
464
Dergi Adı
[dc.relation.journal]
Journal of Biomedical Materials Research - Part A
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
104
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1002/jbm.a.35591
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7461
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
15
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 15:53
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Tıklayınız
nanoparticles glioblastoma cellular salinomycin P80-SAL-PLGA respect viability within treatment coated decreased transported successfully Periodicals greatly activities potential therapeutic induced cytoskeleton damaged observed suggesting changes morphological delivery system Substantial Salinomycin anti-growth poly(lactic-co-glycolic 80-coated polysorbate Salinomycin-encapsulated deliver
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