Plasma total homocysteine levels in a healthy Turkish population sample

Objective - The objective of this study is to determine the reference values of homocysteine levels from a sample of healthy native Turks, and the relationship of these levels with gender, age and other risk factors. Methods and results - Plasma homocysteine level was measured in 159 healthy Turkish individuals. Homocysteine levels were determined by the HPLC method and differences between sex and age groupings (20-40 years, 41-60 years, and 61 and older) were compared. Mean homocysteine levels were 8.91 ± 1.41 µmol/l. The median homocysteine level was 8.35 µmol/l (men 8.80, women 7.0). Homocysteine levels significantly increased with age (r = 0.49) and higher in men than in women in each age group (p < 0.05) (men: 9.51 ± 1.40; women 7.38 ± 1.36; p < 0.001). The cut-off point for high homocysteine level is selected to be the value that marks the upper 20% of the control population distribution (12.26 µmol/l). Postmenopausal > 60-year-old women manifested significantly higher increases in total homocysteine concentrations than 20 to 40-year-old premenopausal women. There were no significant correlations between homocysteine and body mass index, glucose, total and lipoprotein lipids, C-reactive protein, creatinine, smoking and alcohol consumption except blood pressure and uric acid. Conclusions - These data indicate the significance of sex- and age-associated differences of homocysteine levels in native Turkish subjects. Upper reference limits for the plasma total homocysteine concentration increased with age and were higher for men than for women at all ages. Focusing public health initiatives on this issue may reduce the high prevalence of cardiovascular disease in the Turkish population.

Yazar Taskin G.
Yilmaz Sipahi E.
Yildirimkaya M.
Nadirler F.
Halloran M.
Ayoglu F.N.
Laleli Y.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7028
Tek Biçim Adres 10.2143/AC.61.1.2005138
Konu Başlıkları Age
Gender
Homocysteine
Increase in vascular disease risk
Turkish population
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Acta Cardiologica
Dergi Cilt Bilgisi 61
Dergi Sayısı 1
Sayfalar 35 - 42
Yayın Yılı 2006
Eser Adı
[dc.title]
Plasma total homocysteine levels in a healthy Turkish population sample
Yazar
[dc.contributor.author]
Taskin G.
Yazar
[dc.contributor.author]
Yilmaz Sipahi E.
Yazar
[dc.contributor.author]
Yildirimkaya M.
Yazar
[dc.contributor.author]
Nadirler F.
Yazar
[dc.contributor.author]
Halloran M.
Yazar
[dc.contributor.author]
Ayoglu F.N.
Yazar
[dc.contributor.author]
Laleli Y.
Yayın Yılı
[dc.date.issued]
2006
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective - The objective of this study is to determine the reference values of homocysteine levels from a sample of healthy native Turks, and the relationship of these levels with gender, age and other risk factors. Methods and results - Plasma homocysteine level was measured in 159 healthy Turkish individuals. Homocysteine levels were determined by the HPLC method and differences between sex and age groupings (20-40 years, 41-60 years, and 61 and older) were compared. Mean homocysteine levels were 8.91 ± 1.41 µmol/l. The median homocysteine level was 8.35 µmol/l (men 8.80, women 7.0). Homocysteine levels significantly increased with age (r = 0.49) and higher in men than in women in each age group (p < 0.05) (men: 9.51 ± 1.40; women 7.38 ± 1.36; p < 0.001). The cut-off point for high homocysteine level is selected to be the value that marks the upper 20% of the control population distribution (12.26 µmol/l). Postmenopausal > 60-year-old women manifested significantly higher increases in total homocysteine concentrations than 20 to 40-year-old premenopausal women. There were no significant correlations between homocysteine and body mass index, glucose, total and lipoprotein lipids, C-reactive protein, creatinine, smoking and alcohol consumption except blood pressure and uric acid. Conclusions - These data indicate the significance of sex- and age-associated differences of homocysteine levels in native Turkish subjects. Upper reference limits for the plasma total homocysteine concentration increased with age and were higher for men than for women at all ages. Focusing public health initiatives on this issue may reduce the high prevalence of cardiovascular disease in the Turkish population.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Age
Konu Başlıkları
[dc.subject]
Gender
Konu Başlıkları
[dc.subject]
Homocysteine
Konu Başlıkları
[dc.subject]
Increase in vascular disease risk
Konu Başlıkları
[dc.subject]
Turkish population
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0001-5385
İlk Sayfa Sayısı
[dc.identifier.startpage]
35
Son Sayfa Sayısı
[dc.identifier.endpage]
42
Dergi Adı
[dc.relation.journal]
Acta Cardiologica
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
61
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.2143/AC.61.1.2005138
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7028
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
24
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 05:08
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homocysteine levels Turkish higher population Homocysteine between increased significantly differences native healthy reference µmol/l glucose lipoprotein lipids manifested µmol/l) Postmenopausal 60-year-old increases concentrations 40-year-old premenopausal significant correlations C-reactive protein initiatives Focusing public health plasma reduce
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