Helicobacter pylori eradication lowers serum asymmetric dimethylarginine levels

Introduction: Microbial pathogens, one of them is Helicobacter pylori (H. pylori), have frequently been implicated in the atherogenesis. Endothelium-derived nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS) and plays a pivotal role in the regulation of vascular tone. Asymmetric dimethylarginine (ADMA) is the most potent endogenous NOS inhibitor. Elevated levels of ADMA have been reported in many circumstances associated with a high cardiovascular risk. The aim of the present study was to investigate whether the eradication of H. pylori infection affects serum ADMA levels. Materials and Methods. Forty-two H. pylori-positive patients were enrolled in the study. Triple therapy for 14 days were given to all patients. Serum ADMA levels were measured at baseline and 2 months after therapy. Results. Eradication was achieved in 34 (81%) patients. The mean serum ADMA levels before and after therapy were 1,77±0,30 and 1,67±0,29ng/mL in the group with H. pylori eradicated and 1,63±0,28 and 1,56±0,32ng/mL in the noneradicated, respectively. We detected statistically significant decreased serum ADMA levels after therapy in H. pylori eradicated group. Conclusion. These findings have indicated that eradication of H. pylori infection may decrease the risk of atherosclerosis and cardiovascular events. Copyright © 2010 Selim Aydemir et al.

Yazar Aydemir S.
Eren H.
Tekin I.O.
Harmandar F.A.
Demircan N.
Cabuk M.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/6049
Tek Biçim Adres 10.1155/2010/685903
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Mediators of Inflammation
Dergi Cilt Bilgisi 2010
Sayfalar -
Yayın Yılı 2010
Eser Adı
[dc.title]
Helicobacter pylori eradication lowers serum asymmetric dimethylarginine levels
Yazar
[dc.contributor.author]
Aydemir S.
Yazar
[dc.contributor.author]
Eren H.
Yazar
[dc.contributor.author]
Tekin I.O.
Yazar
[dc.contributor.author]
Harmandar F.A.
Yazar
[dc.contributor.author]
Demircan N.
Yazar
[dc.contributor.author]
Cabuk M.
Yayın Yılı
[dc.date.issued]
2010
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Introduction: Microbial pathogens, one of them is Helicobacter pylori (H. pylori), have frequently been implicated in the atherogenesis. Endothelium-derived nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS) and plays a pivotal role in the regulation of vascular tone. Asymmetric dimethylarginine (ADMA) is the most potent endogenous NOS inhibitor. Elevated levels of ADMA have been reported in many circumstances associated with a high cardiovascular risk. The aim of the present study was to investigate whether the eradication of H. pylori infection affects serum ADMA levels. Materials and Methods. Forty-two H. pylori-positive patients were enrolled in the study. Triple therapy for 14 days were given to all patients. Serum ADMA levels were measured at baseline and 2 months after therapy. Results. Eradication was achieved in 34 (81%) patients. The mean serum ADMA levels before and after therapy were 1,77±0,30 and 1,67±0,29ng/mL in the group with H. pylori eradicated and 1,63±0,28 and 1,56±0,32ng/mL in the noneradicated, respectively. We detected statistically significant decreased serum ADMA levels after therapy in H. pylori eradicated group. Conclusion. These findings have indicated that eradication of H. pylori infection may decrease the risk of atherosclerosis and cardiovascular events. Copyright © 2010 Selim Aydemir et al.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0962-9351
Dergi Adı
[dc.relation.journal]
Mediators of Inflammation
Dergi Cilt Bilgisi
[dc.identifier.volume]
2010
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1155/2010/685903
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6049
Görüntülenme Sayısı ( Şehir )
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7
09.12.2022 tarihinden bu yana
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1
09.12.2022 tarihinden bu yana
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10 Nisan 2024 21:49
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pylori levels therapy patients eradicated cardiovascular infection eradication nitric before baseline measured Results achieved Eradication months findings Aydemir Copyright events atherosclerosis decrease indicated Conclusion decreased significant statistically detected respectively noneradicated 32ng/mL 29ng/mL Introduction regulation pivotal
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