Protein carbonyl levels in the aqueous humour and serum of patients with pseudoexfoliation syndrome

Purpose: Protein oxidation is an oxidative stress marker and the oxidation of proteins is analysed by measuring the carbonyl groups. Protein oxidation can have a role in the physiopathology of pseudoexfoliation (PEX) syndrome. The aim of this study was to investigate the protein oxidation in the aqueous humour and serum of cataract patients with and without PEX. Methods: A multicenter study was carried out. Aqueous humour and serum samples were collected from patients who underwent routine cataract surgery. Patients were divided into PEX (n = 29) and control (n = 27) groups. Patients had no elevated intraocular pressure or glaucoma. Spectrophotometer was used to measure protein carbonyl (PC) levels in the samples. Results: Mean PC concentration in the PEX aqueous (2.18 ± 1.51 nmol/l) and serum (119.62 ± 13.2 nmol/l) samples was significantly higher than that measured in the control aqueous (1.31 ± 0.47 nmol/l) and serum (105.85 ± 11.76 nmol/l) samples, respectively (P < 0.001). Conclusion: The increased PC levels in the aqueous humour and serum of PEX patients suggest that protein oxidation may play a role in the physiopathology of PEX.

Yazar Yagci R.
Ersöz I.
Erdurmuş M.
Gürel A.
Duman S.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7242
Tek Biçim Adres 10.1038/sj.eye.6702751
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Eye
Dergi Cilt Bilgisi 22
Dergi Sayısı 1
Sayfalar 128 - 131
Yayın Yılı 2008
Eser Adı
[dc.title]
Protein carbonyl levels in the aqueous humour and serum of patients with pseudoexfoliation syndrome
Yazar
[dc.contributor.author]
Yagci R.
Yazar
[dc.contributor.author]
Ersöz I.
Yazar
[dc.contributor.author]
Erdurmuş M.
Yazar
[dc.contributor.author]
Gürel A.
Yazar
[dc.contributor.author]
Duman S.
Yayın Yılı
[dc.date.issued]
2008
Yayıncı
[dc.publisher]
Nature Publishing Group
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Purpose: Protein oxidation is an oxidative stress marker and the oxidation of proteins is analysed by measuring the carbonyl groups. Protein oxidation can have a role in the physiopathology of pseudoexfoliation (PEX) syndrome. The aim of this study was to investigate the protein oxidation in the aqueous humour and serum of cataract patients with and without PEX. Methods: A multicenter study was carried out. Aqueous humour and serum samples were collected from patients who underwent routine cataract surgery. Patients were divided into PEX (n = 29) and control (n = 27) groups. Patients had no elevated intraocular pressure or glaucoma. Spectrophotometer was used to measure protein carbonyl (PC) levels in the samples. Results: Mean PC concentration in the PEX aqueous (2.18 ± 1.51 nmol/l) and serum (119.62 ± 13.2 nmol/l) samples was significantly higher than that measured in the control aqueous (1.31 ± 0.47 nmol/l) and serum (105.85 ± 11.76 nmol/l) samples, respectively (P < 0.001). Conclusion: The increased PC levels in the aqueous humour and serum of PEX patients suggest that protein oxidation may play a role in the physiopathology of PEX.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0950222X
İlk Sayfa Sayısı
[dc.identifier.startpage]
128
Son Sayfa Sayısı
[dc.identifier.endpage]
131
Dergi Adı
[dc.relation.journal]
Eye
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
22
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1038/sj.eye.6702751
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7242
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
21
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Mayıs 2024 20:40
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Tıklayınız
oxidation aqueous samples nmol/l) patients humour protein cataract control levels Patients carbonyl Protein physiopathology groups Conclusion increased suggest concentration Results measure respectively Spectrophotometer measured higher significantly Purpose glaucoma investigate syndrome pseudoexfoliation Methods measuring analysed proteins
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