Serum glucagon and cystatin C levels with renal doppler sonography findings in non-azotemic liver cirrhosis cases

Background/Aims: It is well known that the hyperdynamic circulatory state in cirrhosis is characterized by increased splanchnic blood flow and renal vasoconstriction. The role of hyperglucagonemia in the renal hemodynamic changes that occur in this patient group is poorly understood at present. This study investigated relationships between serum glucagon levels, indicators of renal function (serum creatinine [Cr] and cystatin C levels, creatinine clearance rate [CrCl]), and renal hemodynamic findings in early and later stages of liver cirrhosis. Methodology: In total, 40 patients with non-azotemic liver cirrhosis (Group 1) and 20 healthy gender- and age-matched controls (Group 2) were enrolled. The patient group was subdivided into Group la (25 patients with compensated cirrhosis [Child-Pugh A score]) and Group lb (15 patients with decompensated cirrhosis [Child-Pugh B or C]). Results: Group 1 patients had significantly elevated serum glucagon levels than Group 2 (57.8±46.7 pmol/L vs. 22.1±8.1 pmol/L, respectively p<0.05). Group 1b had significantly higher mean serum glucagon than Group 1a (97.4±58.8 pmol/L vs. 35.1±15.2 pmol/L, respectively p<0.05). Although there was no difference between Group la and lb with respect to mean serum Cr and CrCl, mean serum cystatin C was significantly higher in group 1b than group 1a (1.6±0.4 mg/L vs. 1.1±0.2 mg/L, respectively p<0.05). Group 1 had a significantly higher mean renal resistive index (RRI) than the control group (0.64±0.1 vs. 0.57±0.01, respectively, p<0,05). According to Spearman's correlation analysis, serum glucagon was correlated with RRI in Group la (compensated stage of liver cirrhosis) (r=0.52, p=0.008), but not in Group lb (decompensated stage of cirrhosis) (r=-0.07, p=0.803). RRI was not correlated with serum Cr, Serum Cystatin C, Or Crcl In Either Patient Subgroup. Conclusions: The findings indicate that hyperglucagonemia may be associated with renal hemodynamic changes in early-stage liver cirrhosis. However, this relationship was not observed in the decompensated stage. © H.G.E. Update Medical Publishing S.A.

Dergi Adı Hepato-Gastroenterology
Dergi Cilt Bilgisi 58
Dergi Sayısı 107-108
Sayfalar 926 - 931
Yayın Yılı 2011
Eser Adı
[dc.title]
Serum glucagon and cystatin C levels with renal doppler sonography findings in non-azotemic liver cirrhosis cases
Yazar
[dc.contributor.author]
Ustundag Y.
Yazar
[dc.contributor.author]
Hekimoglu K.
Yazar
[dc.contributor.author]
Ilikhan S.
Yazar
[dc.contributor.author]
Zaimoglu G.
Yazar
[dc.contributor.author]
Acikgöz S.
Yazar
[dc.contributor.author]
Aydemir S.
Yayın Yılı
[dc.date.issued]
2011
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background/Aims: It is well known that the hyperdynamic circulatory state in cirrhosis is characterized by increased splanchnic blood flow and renal vasoconstriction. The role of hyperglucagonemia in the renal hemodynamic changes that occur in this patient group is poorly understood at present. This study investigated relationships between serum glucagon levels, indicators of renal function (serum creatinine [Cr] and cystatin C levels, creatinine clearance rate [CrCl]), and renal hemodynamic findings in early and later stages of liver cirrhosis. Methodology: In total, 40 patients with non-azotemic liver cirrhosis (Group 1) and 20 healthy gender- and age-matched controls (Group 2) were enrolled. The patient group was subdivided into Group la (25 patients with compensated cirrhosis [Child-Pugh A score]) and Group lb (15 patients with decompensated cirrhosis [Child-Pugh B or C]). Results: Group 1 patients had significantly elevated serum glucagon levels than Group 2 (57.8±46.7 pmol/L vs. 22.1±8.1 pmol/L, respectively p<0.05). Group 1b had significantly higher mean serum glucagon than Group 1a (97.4±58.8 pmol/L vs. 35.1±15.2 pmol/L, respectively p<0.05). Although there was no difference between Group la and lb with respect to mean serum Cr and CrCl, mean serum cystatin C was significantly higher in group 1b than group 1a (1.6±0.4 mg/L vs. 1.1±0.2 mg/L, respectively p<0.05). Group 1 had a significantly higher mean renal resistive index (RRI) than the control group (0.64±0.1 vs. 0.57±0.01, respectively, p<0,05). According to Spearman's correlation analysis, serum glucagon was correlated with RRI in Group la (compensated stage of liver cirrhosis) (r=0.52, p=0.008), but not in Group lb (decompensated stage of cirrhosis) (r=-0.07, p=0.803). RRI was not correlated with serum Cr, Serum Cystatin C, Or Crcl In Either Patient Subgroup. Conclusions: The findings indicate that hyperglucagonemia may be associated with renal hemodynamic changes in early-stage liver cirrhosis. However, this relationship was not observed in the decompensated stage. © H.G.E. Update Medical Publishing S.A.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Child-Pugh score
Konu Başlıkları
[dc.subject]
Cystatin C
Konu Başlıkları
[dc.subject]
Glucagon
Konu Başlıkları
[dc.subject]
Liver cirrhosis
Konu Başlıkları
[dc.subject]
Renal hemodynamics
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0172-6390
İlk Sayfa Sayısı
[dc.identifier.startpage]
926
Son Sayfa Sayısı
[dc.identifier.endpage]
931
Dergi Adı
[dc.relation.journal]
Hepato-Gastroenterology
Dergi Sayısı
[dc.identifier.issue]
107-108
Dergi Cilt Bilgisi
[dc.identifier.volume]
58
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7501
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
55
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
16 Temmuz 2024 11:14
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cirrhosis significantly pmol/L respectively patients glucagon levels hemodynamic higher cystatin findings correlated cirrhosis) creatinine decompensated (Group hyperglucagonemia changes patient [Child-Pugh between control resistive Update Medical Publishing respect difference correlation However early-stage Cystatin Either Patient Subgroup
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