Perinatal risk factors for neonatal intracerebral hemorrhage in preterm infants

Objective: To investigate the perinatal factors related to neonatal intracerebral hemorrhage (ICH) and possibly to define obstetric and perinatal risk factors. Study design: All medical records of women who delivered in the period from 1 January 1991 to 1 January 2000 were reviewed for intracerebral hemorrhages in infants born between 24 and 34 weeks of gestation and treated in the postnatal period. Sixty infants with ICH (Group I) and 60 infants without ICH (Group II, matched controls) were determined for comparison. Obstetrical parameters and risk factors and perinatal outcome parameters were evaluated and statistically analyzed. Results: Neonatal intracerebral hemorrhage prevalence was 0.8% (60/7635 births). Betamethasone administration was significantly less in Group I than in Group II (27% versus 46%). Although Doppler-sonography of the middle cerebral artery was performed in a minority of the cases, it showed a significant tendency of lower resistance indices (brain sparing) in the intracerebral hemorrhage group (66.7% versus 21.1%). Postnatally, infants with intracerebral hemorrhage showed a significantly more often umbilical arterial acidosis (18% versus 10%), a greater base deficit, lower median 5 min Apgar scores (6 and 8, respectively for Groups I and II), and a lower thrombocyte count (Group I 190,000 ± 76,000 µl-1, and Group II 227,000 ± 96,000 µl-1). Infants in Group I were more often (93% versus 76%) and longer (26.7 ± 30.5 days versus 15.4 ± 11.7 days) dependent on ventilatory support than infants in Group II. Mortality rate in Group I (35%) was significantly higher compared to Group II (17%). Conclusions: Antenatal Doppler sonography in predicting intracerebral hemorrhage in preterm infants should be investigated in large scale prospective studies. Postnatal low pH-values (pH < 7.1) and a base deficit of more than -16 mmol/L in the umbilical artery, low Apgar scores and thrombocytopenia are associated with a neonatal intracerebral hemorrhage and prophylaxis with corticosteroids reduces the risk for it. A higher neonatal mortality and morbidity, including neurological and neuromotoric dysfunctions is expected in this clinical entity. © 2004 Elsevier Ireland Ltd. All rights reserved.

Yazar Ertan A.K.
Tanriverdi H.A.
Meier M.
Schmidt W.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/6977
Tek Biçim Adres 10.1016/j.ejogrb.2004.06.008
Konu Başlıkları Doppler sonography
Neonatal intracerebral hemorrhage
Perinatal outcome
Risk factors
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı European Journal of Obstetrics and Gynecology and Reproductive Biology
Dergi Cilt Bilgisi 127
Dergi Sayısı 1
Sayfalar 29 - 34
Yayın Yılı 2006
Eser Adı
[dc.title]
Perinatal risk factors for neonatal intracerebral hemorrhage in preterm infants
Yazar
[dc.contributor.author]
Ertan A.K.
Yazar
[dc.contributor.author]
Tanriverdi H.A.
Yazar
[dc.contributor.author]
Meier M.
Yazar
[dc.contributor.author]
Schmidt W.
Yayın Yılı
[dc.date.issued]
2006
Yayıncı
[dc.publisher]
Elsevier Ireland Ltd
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: To investigate the perinatal factors related to neonatal intracerebral hemorrhage (ICH) and possibly to define obstetric and perinatal risk factors. Study design: All medical records of women who delivered in the period from 1 January 1991 to 1 January 2000 were reviewed for intracerebral hemorrhages in infants born between 24 and 34 weeks of gestation and treated in the postnatal period. Sixty infants with ICH (Group I) and 60 infants without ICH (Group II, matched controls) were determined for comparison. Obstetrical parameters and risk factors and perinatal outcome parameters were evaluated and statistically analyzed. Results: Neonatal intracerebral hemorrhage prevalence was 0.8% (60/7635 births). Betamethasone administration was significantly less in Group I than in Group II (27% versus 46%). Although Doppler-sonography of the middle cerebral artery was performed in a minority of the cases, it showed a significant tendency of lower resistance indices (brain sparing) in the intracerebral hemorrhage group (66.7% versus 21.1%). Postnatally, infants with intracerebral hemorrhage showed a significantly more often umbilical arterial acidosis (18% versus 10%), a greater base deficit, lower median 5 min Apgar scores (6 and 8, respectively for Groups I and II), and a lower thrombocyte count (Group I 190,000 ± 76,000 µl-1, and Group II 227,000 ± 96,000 µl-1). Infants in Group I were more often (93% versus 76%) and longer (26.7 ± 30.5 days versus 15.4 ± 11.7 days) dependent on ventilatory support than infants in Group II. Mortality rate in Group I (35%) was significantly higher compared to Group II (17%). Conclusions: Antenatal Doppler sonography in predicting intracerebral hemorrhage in preterm infants should be investigated in large scale prospective studies. Postnatal low pH-values (pH < 7.1) and a base deficit of more than -16 mmol/L in the umbilical artery, low Apgar scores and thrombocytopenia are associated with a neonatal intracerebral hemorrhage and prophylaxis with corticosteroids reduces the risk for it. A higher neonatal mortality and morbidity, including neurological and neuromotoric dysfunctions is expected in this clinical entity. © 2004 Elsevier Ireland Ltd. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Doppler sonography
Konu Başlıkları
[dc.subject]
Neonatal intracerebral hemorrhage
Konu Başlıkları
[dc.subject]
Perinatal outcome
Konu Başlıkları
[dc.subject]
Risk factors
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0301-2115
İlk Sayfa Sayısı
[dc.identifier.startpage]
29
Son Sayfa Sayısı
[dc.identifier.endpage]
34
Dergi Adı
[dc.relation.journal]
European Journal of Obstetrics and Gynecology and Reproductive Biology
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
127
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.ejogrb.2004.06.008
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6977
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
182
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
15 Temmuz 2024 04:03
Google Kontrol
Tıklayınız
intracerebral hemorrhage infants versus significantly (Group neonatal factors perinatal parameters artery showed higher period scores umbilical January deficit Mortality dependent ventilatory support Objective thrombocyte µl-1) longer Infants investigated compared expected reduces mortality morbidity including neurological
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms