Pretreatment with stellate ganglion blockade before ischemia reduces infarct size in rat hearts

Objectives: To investigate the role of stellate ganglion blockade (SGB) in cardio-protection against ischemia reperfusion injury. Methods: This prospective randomized, experimental study was carried out between August and October 2008 in the Department of Anesthesia, Abant Izzet Baysal University, Bolu, Turkey. Twenty-one rats were randomly divided into 3 groups; group 1 - SGB group (rats with percutaneous ganglion blockade), group 2 - preconditioned (P) group (rats that were subjected to ischemia and then reperfusion periods for 5 minutes), and group 3 - control group (rats that were injected with normal saline). Results: During the ligation period, the length of arrhythmia was significantly shorter in group 2 compared with group 3 (p<0.001). The arrhythmia score in groups 1 and 2 was significantly lower compared with group 3 (p<0.001). In the reperfusion period, the length of arrhythmia was not significantly different in all study groups (p>0.05). But the arrhythmia score was significantly lower both in group 1 and group 3, compared with group 2 (p<0.02). Both in the ischemic and reperfusion periods, the incidence of arrhythmia was lowest in group 1. The infarct size was measured significantly less in groups 1 and 2 compared with group 3 (p<0.001). Conclusion: Pretreatment with the left SGB leads to lower arrhythmia scores and reduced infarct size in the Langendorff-perfused rat hearts compared with group 3, but not with group 2.

Yazar Gulcu-Bulut N.
Gonca E.
Kocoglu H.
Bozdogan O.
Karaaslan K.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7158
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Saudi Medical Journal
Dergi Cilt Bilgisi 31
Dergi Sayısı 2
Sayfalar 148 - 152
Yayın Yılı 2010
Eser Adı
[dc.title]
Pretreatment with stellate ganglion blockade before ischemia reduces infarct size in rat hearts
Yazar
[dc.contributor.author]
Gulcu-Bulut N.
Yazar
[dc.contributor.author]
Gonca E.
Yazar
[dc.contributor.author]
Kocoglu H.
Yazar
[dc.contributor.author]
Bozdogan O.
Yazar
[dc.contributor.author]
Karaaslan K.
Yayın Yılı
[dc.date.issued]
2010
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objectives: To investigate the role of stellate ganglion blockade (SGB) in cardio-protection against ischemia reperfusion injury. Methods: This prospective randomized, experimental study was carried out between August and October 2008 in the Department of Anesthesia, Abant Izzet Baysal University, Bolu, Turkey. Twenty-one rats were randomly divided into 3 groups; group 1 - SGB group (rats with percutaneous ganglion blockade), group 2 - preconditioned (P) group (rats that were subjected to ischemia and then reperfusion periods for 5 minutes), and group 3 - control group (rats that were injected with normal saline). Results: During the ligation period, the length of arrhythmia was significantly shorter in group 2 compared with group 3 (p<0.001). The arrhythmia score in groups 1 and 2 was significantly lower compared with group 3 (p<0.001). In the reperfusion period, the length of arrhythmia was not significantly different in all study groups (p>0.05). But the arrhythmia score was significantly lower both in group 1 and group 3, compared with group 2 (p<0.02). Both in the ischemic and reperfusion periods, the incidence of arrhythmia was lowest in group 1. The infarct size was measured significantly less in groups 1 and 2 compared with group 3 (p<0.001). Conclusion: Pretreatment with the left SGB leads to lower arrhythmia scores and reduced infarct size in the Langendorff-perfused rat hearts compared with group 3, but not with group 2.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0379-5284
İlk Sayfa Sayısı
[dc.identifier.startpage]
148
Son Sayfa Sayısı
[dc.identifier.endpage]
152
Dergi Adı
[dc.relation.journal]
Saudi Medical Journal
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
31
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7158
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
14
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Mayıs 2024 03:47
Google Kontrol
Tıklayınız
arrhythmia significantly compared reperfusion groups infarct ischemia length period ganglion periods shorter ligation During Results Objectives hearts Langendorff-perfused reduced scores Pretreatment Conclusion measured different lowest incidence ischemic normal saline) preconditioned injected Methods August between carried
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms