Structural studies and cytotoxic activity of a new dinuclear coordination compound of palladium(II)–2,2':6',2¨-terpyridine with rigid dianionic 1,2,4-triazole-3-sulfonate linker

A new dinuclear coordination compound of palladium(II), [Pd2(terpy)2(µ-tas-N1,N4)]SO4·11H2O (1), was synthesized by tethering a doubly deprotonated 1,2,4-triazole-3-sulfonate (tas) linker generated in situ via oxidation of 1,2,4-triazole-3-thione (tat) under the synthetic conditions. X-ray diffraction analysis reveals that tat molecules adopt the thione form in the solid state, and are combined in infinite chains by symmetrically related classical intermolecular hydrogen bonds N1¦H1···S1, N3¦H3···N2 to give rise to R2 2(7) pattern in one-dimensional chains along the b-axis propagating along the a-axis. Further short contacts through lone pairs of N2···S1 on the rings between the adjacent chains along the a-axis lead to a two-dimensional network structure. Compound 1 was characterized using infrared, 1H NMR and UV–visible spectroscopies, electrospray ionization mass spectrometry and X-ray crystallography. The crystal structure determination of 1 reveals that the Pd(II) ions are coordinated with four nitrogen atoms: three from terpy and one from tas acting as an end-to-end (µ-1,4) bridging ligand. The Pd(II) ions in 1 adopt a distorted square planar geometry. The anti-growth effect of 1 was tested on colorectal cancer (HCT-15), non-small-cell lung cancer (A549), prostate cancer (PC-3) and cervical cancer (HeLa) cell lines using sulforhodamine B viability assay. The cytotoxic effect was further confirmed using adenosine triphosphate viability assay. Compound 1 shows a promising cytotoxic activity in the diverse cancer cell models in vitro (p <0.0001). Copyright © 2018 John Wiley & Sons, Ltd.

Yazar Işık Büyükekşi S.
Erkısa M.
Şengül A.
Ulukaya E.
Yılmaztepe Oral A.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7659
Tek Biçim Adres 10.1002/aoc.4406
Konu Başlıkları cytotoxicity
dinuclear
palladium
terpyridine
triazole
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Applied Organometallic Chemistry
Dergi Cilt Bilgisi 32
Dergi Sayısı 8
Sayfalar -
Yayın Yılı 2018
Eser Adı
[dc.title]
Structural studies and cytotoxic activity of a new dinuclear coordination compound of palladium(II)–2,2':6',2¨-terpyridine with rigid dianionic 1,2,4-triazole-3-sulfonate linker
Yazar
[dc.contributor.author]
Işık Büyükekşi S.
Yazar
[dc.contributor.author]
Erkısa M.
Yazar
[dc.contributor.author]
Şengül A.
Yazar
[dc.contributor.author]
Ulukaya E.
Yazar
[dc.contributor.author]
Yılmaztepe Oral A.
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
John Wiley and Sons Ltd
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
A new dinuclear coordination compound of palladium(II), [Pd2(terpy)2(µ-tas-N1,N4)]SO4·11H2O (1), was synthesized by tethering a doubly deprotonated 1,2,4-triazole-3-sulfonate (tas) linker generated in situ via oxidation of 1,2,4-triazole-3-thione (tat) under the synthetic conditions. X-ray diffraction analysis reveals that tat molecules adopt the thione form in the solid state, and are combined in infinite chains by symmetrically related classical intermolecular hydrogen bonds N1¦H1···S1, N3¦H3···N2 to give rise to R2 2(7) pattern in one-dimensional chains along the b-axis propagating along the a-axis. Further short contacts through lone pairs of N2···S1 on the rings between the adjacent chains along the a-axis lead to a two-dimensional network structure. Compound 1 was characterized using infrared, 1H NMR and UV–visible spectroscopies, electrospray ionization mass spectrometry and X-ray crystallography. The crystal structure determination of 1 reveals that the Pd(II) ions are coordinated with four nitrogen atoms: three from terpy and one from tas acting as an end-to-end (µ-1,4) bridging ligand. The Pd(II) ions in 1 adopt a distorted square planar geometry. The anti-growth effect of 1 was tested on colorectal cancer (HCT-15), non-small-cell lung cancer (A549), prostate cancer (PC-3) and cervical cancer (HeLa) cell lines using sulforhodamine B viability assay. The cytotoxic effect was further confirmed using adenosine triphosphate viability assay. Compound 1 shows a promising cytotoxic activity in the diverse cancer cell models in vitro (p <0.0001). Copyright © 2018 John Wiley & Sons, Ltd.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
cytotoxicity
Konu Başlıkları
[dc.subject]
dinuclear
Konu Başlıkları
[dc.subject]
palladium
Konu Başlıkları
[dc.subject]
terpyridine
Konu Başlıkları
[dc.subject]
triazole
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0268-2605
Sponsor YAYINCI
[dc.description.sponsorship]
214Z090
Sponsor YAYINCI
[dc.description.sponsorship]
This work was supported by the Turkish Scientific and Technical Research Council (TÜBİTAK; grant number 214Z090). The authors acknowledge Scientific and Technological Research Application and Research Center, Sinop University, Turkey, for the use of the Bruker D8 QUEST diffractometer.
Dergi Adı
[dc.relation.journal]
Applied Organometallic Chemistry
Dergi Sayısı
[dc.identifier.issue]
8
Dergi Cilt Bilgisi
[dc.identifier.volume]
32
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1002/aoc.4406
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7659
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
13
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Şubat 2024 19:39
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cancer chains reveals viability structure effect a-axis Compound Pd(II) cytotoxic confirmed bridging Copyright end-to-end acting distorted nitrogen coordinated determination crystal ligand planar square adenosine triphosphate promising activity diverse sulforhodamine models (HeLa) cervical spectrometry further (PC-3)
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