Oxidative stress markers, C-reactive protein and heat shock protein 70 levels in subjects with metabolic syndrome

Background: The metabolic syndrome is a cluster of cardiovascular risk factors and essential components of metabolic syndrome are hyperglycemia, hypertension, visceral obesity, hypertriglyceridemia and low high-density lipoprotein cholesterol. Oxidative stress plays a critical role in the pathogenesis of metabolic syndrome components and insulin resistance. The aim of this study was to investigate the role of oxidative stress, C-reactive protein and heat shock protein 70 levels in the pathogenesis of this disease. Methods: A total of 36 patients diagnosed with metabolic syndrome and 33 controls were included in the study. Malondialdehyde, carbonyl protein, C-reactive protein and heat shock protein 70 levels and xanthine oxidase and superoxide dismutase activities were measured in the serum of the subjects. Results: Mean serum malondialdehyde, carbonyl protein, C-reactive protein (p<0.01, p<0.05 and p<0.001, respectively) and xanthine oxidase activity were significantly higher (p<0.01) in serum of the patients than the control group. Superoxide dismutase activity and heat shock protein 70 levels were significantly lower (p<0.01 and p<0.05, respectively) in serum of the patients. Conclusions: These results suggest that oxidative stress parameters and components of metabolic syndrome are closely related; therefore, significant alterations may occur in the antioxidant and inflammatory status. However, further studies are required to evaluate the possible molecular mechanisms of heat shock protein 70 levels in metabolic syndrome. © 2008 by Walter de Gruyter.

Dergi Adı Clinical Chemistry and Laboratory Medicine
Dergi Cilt Bilgisi 46
Dergi Sayısı 6
Sayfalar 785 - 790
Yayın Yılı 2008
Eser Adı
[dc.title]
Oxidative stress markers, C-reactive protein and heat shock protein 70 levels in subjects with metabolic syndrome
Yazar
[dc.contributor.author]
Armutcu F.
Yazar
[dc.contributor.author]
Ataymen M.
Yazar
[dc.contributor.author]
Atmaca H.
Yazar
[dc.contributor.author]
Gurel A.
Yayın Yılı
[dc.date.issued]
2008
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: The metabolic syndrome is a cluster of cardiovascular risk factors and essential components of metabolic syndrome are hyperglycemia, hypertension, visceral obesity, hypertriglyceridemia and low high-density lipoprotein cholesterol. Oxidative stress plays a critical role in the pathogenesis of metabolic syndrome components and insulin resistance. The aim of this study was to investigate the role of oxidative stress, C-reactive protein and heat shock protein 70 levels in the pathogenesis of this disease. Methods: A total of 36 patients diagnosed with metabolic syndrome and 33 controls were included in the study. Malondialdehyde, carbonyl protein, C-reactive protein and heat shock protein 70 levels and xanthine oxidase and superoxide dismutase activities were measured in the serum of the subjects. Results: Mean serum malondialdehyde, carbonyl protein, C-reactive protein (p<0.01, p<0.05 and p<0.001, respectively) and xanthine oxidase activity were significantly higher (p<0.01) in serum of the patients than the control group. Superoxide dismutase activity and heat shock protein 70 levels were significantly lower (p<0.01 and p<0.05, respectively) in serum of the patients. Conclusions: These results suggest that oxidative stress parameters and components of metabolic syndrome are closely related; therefore, significant alterations may occur in the antioxidant and inflammatory status. However, further studies are required to evaluate the possible molecular mechanisms of heat shock protein 70 levels in metabolic syndrome. © 2008 by Walter de Gruyter.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
C-reactive protein
Konu Başlıkları
[dc.subject]
Carbonyl protein
Konu Başlıkları
[dc.subject]
Heat shock protein 70
Konu Başlıkları
[dc.subject]
Metabolic syndrome
Konu Başlıkları
[dc.subject]
Oxidative stress
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1434-6621
İlk Sayfa Sayısı
[dc.identifier.startpage]
785
Son Sayfa Sayısı
[dc.identifier.endpage]
790
Dergi Adı
[dc.relation.journal]
Clinical Chemistry and Laboratory Medicine
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
46
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1515/CCLM.2008.166
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6905
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
32
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Nisan 2024 06:59
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protein metabolic syndrome levels components stress patients C-reactive pathogenesis oxidative dismutase carbonyl xanthine oxidase significantly activity respectively) Conclusions Superoxide suggest control higher results Background required Gruyter Walter mechanisms molecular possible evaluate studies parameters further However
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