Serum cardiovascular risk factors in obstructive sleep apnea

Background: Obstructive sleep apnea (OSA) patients have increased cardiovascular morbidity and mortality. The cardiovascular markers associated with OSA are currently not defined. Objectives: The aims of this study were to determine whether OSA is associated with serum cardiac risk markers and to investigate the relationship between them. Methods: Sixty-two male patients were classified into two groups with respect to apnea-hypopnea index (AHI): group 1, sleep apnea (n = 30), with AHI > 5; and group 2 (n = 32), with AHI < 5. We compared cardiovascular risk factors in both groups with control subjects (n = 30) without OSA (AHI < 1). Serum cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A-I, apolipoprotein B, lipoprotein (a), C-reactive protein (CRP), and homocysteine were measured. Statistical significance was assessed with analysis of variance at p < 0.05. In correlation analysis, Pearson correlation was used. Results: There was no significant difference between group 1 and group 2 in total cholesterol, LDL-C, HDL-C, triglyceride, apolipoprotein A-I, apolipoprotein B, and lipoprotein (a). All of the M-mode echocardiographic parameters were in the normal reference range. Serum homocysteine and CRP levels were significantly increased in group 1 compared to group 2 (p < 0.05). Serum CRP values were increased in both group 1 and group 2 when compared with control subjects (p < 0.05). Serum homocysteine values were higher in group 1 than in control subjects (p < 0.05). Conclusions: Our results show that OSA syndrome is associated not only with slight hyperhomocysteinemia but also with increased CRP concentrations. Increased plasma concentrations of homocysteine and CRP can be useful in clinical practice to be predictor of long-term prognosis for cardiovascular disease and the treatment of OSA.

Yazar Can M.
Açikgöz Ş.
Mungan G.
Bayraktaroglu T.
Koçak E.
Güven B.
Demirtas S.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7499
Tek Biçim Adres 10.1378/chest.129.2.233
Konu Başlıkları C-reactive protein
Homocysteine
Obstructive sleep apnea
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Chest
Dergi Cilt Bilgisi 129
Dergi Sayısı 2
Sayfalar 233 - 237
Yayın Yılı 2006
Eser Adı
[dc.title]
Serum cardiovascular risk factors in obstructive sleep apnea
Yazar
[dc.contributor.author]
Can M.
Yazar
[dc.contributor.author]
Açikgöz Ş.
Yazar
[dc.contributor.author]
Mungan G.
Yazar
[dc.contributor.author]
Bayraktaroglu T.
Yazar
[dc.contributor.author]
Koçak E.
Yazar
[dc.contributor.author]
Güven B.
Yazar
[dc.contributor.author]
Demirtas S.
Yayın Yılı
[dc.date.issued]
2006
Yayıncı
[dc.publisher]
American College of Chest Physicians
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: Obstructive sleep apnea (OSA) patients have increased cardiovascular morbidity and mortality. The cardiovascular markers associated with OSA are currently not defined. Objectives: The aims of this study were to determine whether OSA is associated with serum cardiac risk markers and to investigate the relationship between them. Methods: Sixty-two male patients were classified into two groups with respect to apnea-hypopnea index (AHI): group 1, sleep apnea (n = 30), with AHI > 5; and group 2 (n = 32), with AHI < 5. We compared cardiovascular risk factors in both groups with control subjects (n = 30) without OSA (AHI < 1). Serum cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A-I, apolipoprotein B, lipoprotein (a), C-reactive protein (CRP), and homocysteine were measured. Statistical significance was assessed with analysis of variance at p < 0.05. In correlation analysis, Pearson correlation was used. Results: There was no significant difference between group 1 and group 2 in total cholesterol, LDL-C, HDL-C, triglyceride, apolipoprotein A-I, apolipoprotein B, and lipoprotein (a). All of the M-mode echocardiographic parameters were in the normal reference range. Serum homocysteine and CRP levels were significantly increased in group 1 compared to group 2 (p < 0.05). Serum CRP values were increased in both group 1 and group 2 when compared with control subjects (p < 0.05). Serum homocysteine values were higher in group 1 than in control subjects (p < 0.05). Conclusions: Our results show that OSA syndrome is associated not only with slight hyperhomocysteinemia but also with increased CRP concentrations. Increased plasma concentrations of homocysteine and CRP can be useful in clinical practice to be predictor of long-term prognosis for cardiovascular disease and the treatment of OSA.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
C-reactive protein
Konu Başlıkları
[dc.subject]
Homocysteine
Konu Başlıkları
[dc.subject]
Obstructive sleep apnea
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0012-3692
İlk Sayfa Sayısı
[dc.identifier.startpage]
233
Son Sayfa Sayısı
[dc.identifier.endpage]
237
Dergi Adı
[dc.relation.journal]
Chest
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
129
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1378/chest.129.2.233
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7499
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
21
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
03 Şubat 2024 14:03
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homocysteine apolipoprotein cholesterol lipoprotein cardiovascular increased compared control subjects associated concentrations values markers triglyceride analysis patients correlation groups between difference M-mode echocardiographic normal parameters Results reference significant treatment disease prognosis long-term predictor practice clinical useful
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