Role of anti-adhesive barriers following rotator cuff repair surgery: An experimental study

Objective: This experimental study investigates the effectiveness of expanded polytetrafluoroethylene (Dualmesh®, Gore Medical, Flagstaff, AZ, USA), sodium hyaluronate-carboxymethyl cellulose (Seprafilm ®, Genzyme, Cambridge, MA, USA), and polysiloxane (silicone) as anti-adhesive barriers for inhibition of fibrosis in the subacromial area following rotator cuff repair. Methods: Rabbit rotator cuff tenotomy and repair was conducted on 24 rabbits in 4 groups: control (Group A), Dualmesh® (Group B), Seprafilm® (Group C), and silicone (Group D). Anti-adhesive barrier materials were sutured over the repaired rotator cuff. Macroscopic and histological evaluations were made at the end of the sixth postoperative week. Results: Macroscopic evaluation revealed that minimal adhesion occurred in the control and silicone groups, while the Seprafilm® and Dualmesh® groups showed evidence of fibrosis. Microscopic evaluation revealed diffuse fibrosis and collagen accumulation in the Dualmesh® and Seprafilm® groups, whereas minimal collagen deposition and inflammatory cell reaction was found among the silicone and control groups. Significant differences were found between the silicone and Dualmesh® (p=0.001) and silicone and Seprafilm® groups (p=0.002), as well as between the control and Dualmesh® (p=0.002) and control and Seprafilm® groups (p=0.002). Conclusion: Expanded polytetrafluoroethylene (ePTFE/Dualmesh®) and sodium hyaluronate carboxymethyl cellulose (SH-CMC/Seprafilm®) did not prevent or attenuate postoperative subacromial fibrosis following cuff tear repair. Nor did silicone prevent or attenuate fibrosis. More detailed research is needed for development of an effective anti-adhesive barrier for use after rotator cuff tear surgery. © 2016 Turkish Association of Orthopaedics and Traumatology.

Yazar Kalem M.
Şahin E.
Songür M.
Zehir S.
Armangil M.
Demirtas M.A.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7443
Tek Biçim Adres 10.3944/AOTT.2015.15.0134
Konu Başlıkları Antiadhesive barrier
Rotator cuff
Subacromial fibrosis
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Acta Orthopaedica et Traumatologica Turcica
Dergi Cilt Bilgisi 50
Dergi Sayısı 2
Sayfalar 227 - 233
Yayın Yılı 2016
Eser Adı
[dc.title]
Role of anti-adhesive barriers following rotator cuff repair surgery: An experimental study
Yazar
[dc.contributor.author]
Kalem M.
Yazar
[dc.contributor.author]
Şahin E.
Yazar
[dc.contributor.author]
Songür M.
Yazar
[dc.contributor.author]
Zehir S.
Yazar
[dc.contributor.author]
Armangil M.
Yazar
[dc.contributor.author]
Demirtas M.A.
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
Ekin Medical Publishing
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: This experimental study investigates the effectiveness of expanded polytetrafluoroethylene (Dualmesh®, Gore Medical, Flagstaff, AZ, USA), sodium hyaluronate-carboxymethyl cellulose (Seprafilm ®, Genzyme, Cambridge, MA, USA), and polysiloxane (silicone) as anti-adhesive barriers for inhibition of fibrosis in the subacromial area following rotator cuff repair. Methods: Rabbit rotator cuff tenotomy and repair was conducted on 24 rabbits in 4 groups: control (Group A), Dualmesh® (Group B), Seprafilm® (Group C), and silicone (Group D). Anti-adhesive barrier materials were sutured over the repaired rotator cuff. Macroscopic and histological evaluations were made at the end of the sixth postoperative week. Results: Macroscopic evaluation revealed that minimal adhesion occurred in the control and silicone groups, while the Seprafilm® and Dualmesh® groups showed evidence of fibrosis. Microscopic evaluation revealed diffuse fibrosis and collagen accumulation in the Dualmesh® and Seprafilm® groups, whereas minimal collagen deposition and inflammatory cell reaction was found among the silicone and control groups. Significant differences were found between the silicone and Dualmesh® (p=0.001) and silicone and Seprafilm® groups (p=0.002), as well as between the control and Dualmesh® (p=0.002) and control and Seprafilm® groups (p=0.002). Conclusion: Expanded polytetrafluoroethylene (ePTFE/Dualmesh®) and sodium hyaluronate carboxymethyl cellulose (SH-CMC/Seprafilm®) did not prevent or attenuate postoperative subacromial fibrosis following cuff tear repair. Nor did silicone prevent or attenuate fibrosis. More detailed research is needed for development of an effective anti-adhesive barrier for use after rotator cuff tear surgery. © 2016 Turkish Association of Orthopaedics and Traumatology.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Antiadhesive barrier
Konu Başlıkları
[dc.subject]
Rotator cuff
Konu Başlıkları
[dc.subject]
Subacromial fibrosis
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1017995X
İlk Sayfa Sayısı
[dc.identifier.startpage]
227
Son Sayfa Sayısı
[dc.identifier.endpage]
233
Dergi Adı
[dc.relation.journal]
Acta Orthopaedica et Traumatologica Turcica
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
50
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.3944/AOTT.2015.15.0134
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7443
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
28
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
22 Şubat 2024 09:40
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Tıklayınız
groups silicone control Seprafilm® Dualmesh® fibrosis rotator (Group repair subacromial prevent following attenuate barrier between Macroscopic anti-adhesive postoperative minimal revealed evaluation collagen polytetrafluoroethylene sodium cellulose inflammatory deposition differences Significant accumulation diffuse reaction Microscopic whereas development
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