Protective effects of caffeic acid phenethyl ester against experimental allergic encephalomyelitis-induced oxidative stress in rats

Because oxidative damage has been known to be involved in inflammatory and autoimmune-mediated tissue destruction, modulation of oxygen free radical production represents a new approach to the treatment of inflammatory and autoimmune diseases. Central nervous system tissue is particularly vulnerable to oxidative damage, suggesting that oxidation plays an important role in the pathogenesis of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Caffeic acid phenethyl ester (CAPE), an active component of honeybee propolis, has been determined to have antioxidant, anti-inflammatory, antiviral, and anticancer activities. We have previously reported that CAPE inhibits ischemia-reperfusion injury and oxidative stress in rabbit spinal cord tissue. The present study, therefore, examined effects of CAPE on oxidative tissue damage in EAE in rats. Treatment with CAPE significantly inhibited reactive oxygen species (ROS) production induced by EAE, and ameliorated clinical symptoms in rats. These results suggest that CAPE may exert its anti-inflammatory effect by inhibiting ROS production at the transcriptional level through the suppression of nuclear factor ?B activation, and by directly inhibiting the catalytic activity of inducible nitric oxide synthase. © 2004 Elsevier Inc. All rights reserved.

Dergi Adı Free Radical Biology and Medicine
Dergi Cilt Bilgisi 37
Dergi Sayısı 3
Sayfalar 386 - 394
Yayın Yılı 2004
Eser Adı
[dc.title]
Protective effects of caffeic acid phenethyl ester against experimental allergic encephalomyelitis-induced oxidative stress in rats
Yazar
[dc.contributor.author]
Ilhan A.
Yazar
[dc.contributor.author]
Akyol O.
Yazar
[dc.contributor.author]
Gurel A.
Yazar
[dc.contributor.author]
Armutcu F.
Yazar
[dc.contributor.author]
Iraz M.
Yazar
[dc.contributor.author]
Oztas E.
Yayın Yılı
[dc.date.issued]
2004
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Because oxidative damage has been known to be involved in inflammatory and autoimmune-mediated tissue destruction, modulation of oxygen free radical production represents a new approach to the treatment of inflammatory and autoimmune diseases. Central nervous system tissue is particularly vulnerable to oxidative damage, suggesting that oxidation plays an important role in the pathogenesis of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Caffeic acid phenethyl ester (CAPE), an active component of honeybee propolis, has been determined to have antioxidant, anti-inflammatory, antiviral, and anticancer activities. We have previously reported that CAPE inhibits ischemia-reperfusion injury and oxidative stress in rabbit spinal cord tissue. The present study, therefore, examined effects of CAPE on oxidative tissue damage in EAE in rats. Treatment with CAPE significantly inhibited reactive oxygen species (ROS) production induced by EAE, and ameliorated clinical symptoms in rats. These results suggest that CAPE may exert its anti-inflammatory effect by inhibiting ROS production at the transcriptional level through the suppression of nuclear factor ?B activation, and by directly inhibiting the catalytic activity of inducible nitric oxide synthase. © 2004 Elsevier Inc. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Caffeic acid phenethyl ester
Konu Başlıkları
[dc.subject]
Experimental autoimmune encephalomyelitis
Konu Başlıkları
[dc.subject]
Free radicals
Konu Başlıkları
[dc.subject]
Neurologic outcome
Konu Başlıkları
[dc.subject]
Oxidative stress
Konu Başlıkları
[dc.subject]
Spinal cord
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0891-5849
İlk Sayfa Sayısı
[dc.identifier.startpage]
386
Son Sayfa Sayısı
[dc.identifier.endpage]
394
Dergi Adı
[dc.relation.journal]
Free Radical Biology and Medicine
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
37
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.freeradbiomed.2004.04.022
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7234
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
25
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Şubat 2024 06:55
Google Kontrol
Tıklayınız
oxidative tissue production damage autoimmune anti-inflammatory oxygen inhibiting inflammatory ameliorated species clinical symptoms induced Because reactive inhibited significantly Treatment effects examined therefore present results transcriptional suggest catalytic reserved rights Elsevier synthase nitric inducible activity directly
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms