Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism

There is great evidence in recent years that oxygen free radicals play an important role in the pathophysiology of many neuropsychiatric disorders. The present study was performed to assess the changes in red blood cells thiobarbituric acid-reactive substances (TBARS) levels, and Superoxide dismutase (SOD), catalase (CAT), adenosine deaminase (ADA) and xanthine oxidase (XO) activities in patients with autism (n = 27) compared to age- and sex-matched normal controls (n = 26). In the autistic group, increased TBARS levels (p < 0.001) and XO (p < 0.001) and SOD (p < 0.001) activity, decreased CAT (p < 0.001) activity and unchanged ADA activity were detected. It is proposed that antioxidant status may be changed in autism and this new situation may induce lipid peroxidation. These findings indicated a possible role of increased oxidative stress and altered enzymatic antioxidants, both of which may be relevant to the pathophysiology of autism.

Dergi Adı European Archives of Psychiatry and Clinical Neuroscience
Dergi Cilt Bilgisi 254
Dergi Sayısı 3
Sayfalar 143 - 147
Yayın Yılı 2004
Eser Adı
[dc.title]
Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism
Yazar
[dc.contributor.author]
Zoroglu S.S.
Yazar
[dc.contributor.author]
Armutcu F.
Yazar
[dc.contributor.author]
Ozen S.
Yazar
[dc.contributor.author]
Gurel A.
Yazar
[dc.contributor.author]
Sivasli E.
Yazar
[dc.contributor.author]
Yetkin O.
Yazar
[dc.contributor.author]
Meram I.
Yayın Yılı
[dc.date.issued]
2004
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
There is great evidence in recent years that oxygen free radicals play an important role in the pathophysiology of many neuropsychiatric disorders. The present study was performed to assess the changes in red blood cells thiobarbituric acid-reactive substances (TBARS) levels, and Superoxide dismutase (SOD), catalase (CAT), adenosine deaminase (ADA) and xanthine oxidase (XO) activities in patients with autism (n = 27) compared to age- and sex-matched normal controls (n = 26). In the autistic group, increased TBARS levels (p < 0.001) and XO (p < 0.001) and SOD (p < 0.001) activity, decreased CAT (p < 0.001) activity and unchanged ADA activity were detected. It is proposed that antioxidant status may be changed in autism and this new situation may induce lipid peroxidation. These findings indicated a possible role of increased oxidative stress and altered enzymatic antioxidants, both of which may be relevant to the pathophysiology of autism.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Adenosine deaminase (ADA)
Konu Başlıkları
[dc.subject]
Autism
Konu Başlıkları
[dc.subject]
Catalase (CAT)
Konu Başlıkları
[dc.subject]
Free radicals
Konu Başlıkları
[dc.subject]
Superoxide dismutase (SOD)
Konu Başlıkları
[dc.subject]
Thiobarbituric acid-reactive substances (TBARS)
Konu Başlıkları
[dc.subject]
Xanthine oxidase (XO)
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0940-1334
İlk Sayfa Sayısı
[dc.identifier.startpage]
143
Son Sayfa Sayısı
[dc.identifier.endpage]
147
Dergi Adı
[dc.relation.journal]
European Archives of Psychiatry and Clinical Neuroscience
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
254
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s00406-004-0456-7
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6207
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
23
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 01:08
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Tıklayınız
autism activity increased levels pathophysiology findings decreased oxidative stress altered enzymatic unchanged antioxidants relevant autistic changed indicated peroxidation induce situation controls status antioxidant proposed detected possible normal changes assess performed present disorders neuropsychiatric important radicals
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