Plateletcrit in Ocular Pseudoexfoliation Syndrome

Purpose: The aim of this study was to compare all platelet markers, especially plateletcrit (PCT, total platelet mass), in patients with and without ocular pseudoexfoliation (PEX) syndrome. Methods: One hundred six patients with ocular PEX syndrome (study group) and 106 individuals without ocular PEX syndrome (control group) were enrolled in this retrospective case-control study. The biochemical/hematological laboratory results of both the study and control groups were analyzed by a clinician blinded to the group assignments. The main outcome measures were the PCT, platelet count (PLT), mean platelet volume (MPV), and platelet distribution width (PDW). Results: The mean PCT in the study and control groups were 0.206%±0.520% and 0.171%±0.410%, respectively (P<0.001), and the mean PDW in the study and control groups were 16.12%±1.21% and 14.68%±1.40%, respectively (P<0.001). There were no differences in the MPV or mean PLT (P0.138 and P0.055, respectively). The PCT cutoff value was 0.180 (area under the receiver operating characteristics curve, 0.706; P<0.001; 65% sensitivity; 74% specificity). Conclusions: The PCT and PDW were significantly higher in patients with than without ocular PEX syndrome. These increased parameters may cause microvascular blood flow resistance and the heightened inflammatory response caused by excessive platelet activity, as with other cardiovascular diseases, and may also decrease aqueous humor outflow in ocular PEX syndrome. © 2015 Contact Lens Association of Ophthalmologists.

Dergi Adı Eye and Contact Lens
Dergi Cilt Bilgisi 42
Dergi Sayısı 5
Sayfalar 328 - 332
Yayın Yılı 2016
Eser Adı
[dc.title]
Plateletcrit in Ocular Pseudoexfoliation Syndrome
Yazar
[dc.contributor.author]
Yazgan S.
Yazar
[dc.contributor.author]
Celik U.
Yazar
[dc.contributor.author]
Kaldirim H.
Yazar
[dc.contributor.author]
Ayar O.
Yazar
[dc.contributor.author]
Akdemir M.O.
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
Lippincott Williams and Wilkins
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Purpose: The aim of this study was to compare all platelet markers, especially plateletcrit (PCT, total platelet mass), in patients with and without ocular pseudoexfoliation (PEX) syndrome. Methods: One hundred six patients with ocular PEX syndrome (study group) and 106 individuals without ocular PEX syndrome (control group) were enrolled in this retrospective case-control study. The biochemical/hematological laboratory results of both the study and control groups were analyzed by a clinician blinded to the group assignments. The main outcome measures were the PCT, platelet count (PLT), mean platelet volume (MPV), and platelet distribution width (PDW). Results: The mean PCT in the study and control groups were 0.206%±0.520% and 0.171%±0.410%, respectively (P<0.001), and the mean PDW in the study and control groups were 16.12%±1.21% and 14.68%±1.40%, respectively (P<0.001). There were no differences in the MPV or mean PLT (P0.138 and P0.055, respectively). The PCT cutoff value was 0.180 (area under the receiver operating characteristics curve, 0.706; P<0.001; 65% sensitivity; 74% specificity). Conclusions: The PCT and PDW were significantly higher in patients with than without ocular PEX syndrome. These increased parameters may cause microvascular blood flow resistance and the heightened inflammatory response caused by excessive platelet activity, as with other cardiovascular diseases, and may also decrease aqueous humor outflow in ocular PEX syndrome. © 2015 Contact Lens Association of Ophthalmologists.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Excessive platelet activity
Konu Başlıkları
[dc.subject]
Mean platelet volume
Konu Başlıkları
[dc.subject]
Ocular pseudoexfoliation syndrome
Konu Başlıkları
[dc.subject]
Platelet distribution width
Konu Başlıkları
[dc.subject]
Plateletcrit
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1542-2321
İlk Sayfa Sayısı
[dc.identifier.startpage]
328
Son Sayfa Sayısı
[dc.identifier.endpage]
332
Dergi Adı
[dc.relation.journal]
Eye and Contact Lens
Dergi Sayısı
[dc.identifier.issue]
5
Dergi Cilt Bilgisi
[dc.identifier.volume]
42
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1097/ICL.0000000000000197
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7034
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
46
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Nisan 2024 03:48
Google Kontrol
Tıklayınız
platelet ocular syndrome without patients groups control group) respectively sensitivity specificity) Purpose characteristics operating receiver significantly cutoff respectively) Conclusions microvascular higher Ophthalmologists Association Contact outflow aqueous decrease diseases cardiovascular activity excessive caused response inflammatory heightened
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms