Immature Platelet Count Levels as a Novel Quality Marker in Plateletpheresis

The efficiency of plateletpheresis was improved owing to new developments in automated cell separators in the past decades. Nowadays multiple units of plateletpheresis products can be taken per collection from single donor and new parameters such as immature platelet fraction (IPF), immature platelet count (IPC) can be detected practically by automated hematology analyzers. Our aim is to find out a new quality parameter for evaluation of plateletpheresis by analyzing the platelet indices of donor and also to predict platelet recovery in recipients thereby preventing unnecessary platelet transfusion. In this study 104 platelet apheresis procedures were performed on the Trima Accel cell separator. Complete blood counts of donors and recipients were analyzed by Sysmex XN-1000 automated blood cell counter by means of quality parameters such as platelet count, IPF, IPC, mean platelet volume, platelet distribution width. We analyzed these parameters in the follow up after the transfusion of plateletpheresis and evaluated them as quality markers in the assessment of plateletpheresis effectiveness. For recipients of both single and double unit apheresis platelet transfusions, the pre-apheresis donor IPC correlated significantly with 1st and 24th hour recipient IPC values (p values < 0.05 for all comparisons). A-IPC as well as % change in IPF can be used to determine the quality of plateletpheresis in conjunction with platelet number in terms of evaluation of donors and also in the follow up of recipients undergoing platelet transfusion. © 2018, Indian Society of Hematology and Blood Transfusion.

Yazar Unay Demirel O.
Ignak S.
Buyukuysal M.C.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/6148
Tek Biçim Adres 10.1007/s12288-018-0965-6
Konu Başlıkları Complete blood count
Platelet indices
Plateletpheresis
Reticulated platelets
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Indian Journal of Hematology and Blood Transfusion
Dergi Cilt Bilgisi 34
Dergi Sayısı 4
Sayfalar 684 - 690
Yayın Yılı 2018
Eser Adı
[dc.title]
Immature Platelet Count Levels as a Novel Quality Marker in Plateletpheresis
Yazar
[dc.contributor.author]
Unay Demirel O.
Yazar
[dc.contributor.author]
Ignak S.
Yazar
[dc.contributor.author]
Buyukuysal M.C.
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
Springer
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The efficiency of plateletpheresis was improved owing to new developments in automated cell separators in the past decades. Nowadays multiple units of plateletpheresis products can be taken per collection from single donor and new parameters such as immature platelet fraction (IPF), immature platelet count (IPC) can be detected practically by automated hematology analyzers. Our aim is to find out a new quality parameter for evaluation of plateletpheresis by analyzing the platelet indices of donor and also to predict platelet recovery in recipients thereby preventing unnecessary platelet transfusion. In this study 104 platelet apheresis procedures were performed on the Trima Accel cell separator. Complete blood counts of donors and recipients were analyzed by Sysmex XN-1000 automated blood cell counter by means of quality parameters such as platelet count, IPF, IPC, mean platelet volume, platelet distribution width. We analyzed these parameters in the follow up after the transfusion of plateletpheresis and evaluated them as quality markers in the assessment of plateletpheresis effectiveness. For recipients of both single and double unit apheresis platelet transfusions, the pre-apheresis donor IPC correlated significantly with 1st and 24th hour recipient IPC values (p values < 0.05 for all comparisons). A-IPC as well as % change in IPF can be used to determine the quality of plateletpheresis in conjunction with platelet number in terms of evaluation of donors and also in the follow up of recipients undergoing platelet transfusion. © 2018, Indian Society of Hematology and Blood Transfusion.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Complete blood count
Konu Başlıkları
[dc.subject]
Platelet indices
Konu Başlıkları
[dc.subject]
Plateletpheresis
Konu Başlıkları
[dc.subject]
Reticulated platelets
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0971-4502
İlk Sayfa Sayısı
[dc.identifier.startpage]
684
Son Sayfa Sayısı
[dc.identifier.endpage]
690
Dergi Adı
[dc.relation.journal]
Indian Journal of Hematology and Blood Transfusion
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
34
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s12288-018-0965-6
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6148
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
12
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 22:12
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Tıklayınız
platelet plateletpheresis quality recipients parameters transfusion automated apheresis immature evaluation values single follow analyzed donors volume distribution transfusions double effectiveness assessment markers evaluated pre-apheresis correlated Transfusion Hematology Society Indian undergoing number conjunction determine change significantly
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