Serum and BAL cytokine and antioxidant enzyme levels at different stages of pneumoconiosis in coal workers

Coal workers' pneumoconiosis (CWP) is an occupational pulmonary disease that occurs by chronic inhalation of coal dust. CWP is divided into two stages depending on the extent of the disease, as simple pneumoconiosis (SP) and progressive massive fibrosis (PMF). In the present study, serum and bronchoalveolar lavage (BAL) cytokine (interleukin-1ß [IL-1ß], IL-6, tumor necrosis factor-? [TNF-?], transforming growth factor-ß [TGF-ß]) and antioxidant enzymes levels, their relation with the disease severity, and whether they can be considered as biological markers were investigated. Serum and BAL levels of IL-1ß, IL-6, and TNF-? were higher in SP and PMF patient groups compared with that in active and retired miner groups. Serum and BAL IL-1ß, IL-6, and TNF-? levels were also found to be higher in patients with PMF compared with the SP group. BAL superoxide dismutase (SOD), glutathione peroxidase, and catalase levels and serum SOD level were increased in both patient groups compared with the control group. In addition, mean serum and BAL TGF-ß levels were found to be increased in patients with SP compared with PMF group. Based on these results, BAL and serum cytokine and antioxidant enzymes levels were evaluated and discussed as potential biomarkers for different stages of CWP. © 2008 SAGE Publications.

Yazar Ulker O.C.
Yucesoy B.
Demir O.
Tekin I.O.
Karakaya A.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7497
Tek Biçim Adres 10.1177/0960327108098332
Konu Başlıkları Antioxidant enzymes
Coal workers' pneumoconiosis
Proinflammatory cytokines
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Human and Experimental Toxicology
Dergi Cilt Bilgisi 27
Dergi Sayısı 12
Sayfalar 871 - 877
Yayın Yılı 2008
Eser Adı
[dc.title]
Serum and BAL cytokine and antioxidant enzyme levels at different stages of pneumoconiosis in coal workers
Yazar
[dc.contributor.author]
Ulker O.C.
Yazar
[dc.contributor.author]
Yucesoy B.
Yazar
[dc.contributor.author]
Demir O.
Yazar
[dc.contributor.author]
Tekin I.O.
Yazar
[dc.contributor.author]
Karakaya A.
Yayın Yılı
[dc.date.issued]
2008
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Coal workers' pneumoconiosis (CWP) is an occupational pulmonary disease that occurs by chronic inhalation of coal dust. CWP is divided into two stages depending on the extent of the disease, as simple pneumoconiosis (SP) and progressive massive fibrosis (PMF). In the present study, serum and bronchoalveolar lavage (BAL) cytokine (interleukin-1ß [IL-1ß], IL-6, tumor necrosis factor-? [TNF-?], transforming growth factor-ß [TGF-ß]) and antioxidant enzymes levels, their relation with the disease severity, and whether they can be considered as biological markers were investigated. Serum and BAL levels of IL-1ß, IL-6, and TNF-? were higher in SP and PMF patient groups compared with that in active and retired miner groups. Serum and BAL IL-1ß, IL-6, and TNF-? levels were also found to be higher in patients with PMF compared with the SP group. BAL superoxide dismutase (SOD), glutathione peroxidase, and catalase levels and serum SOD level were increased in both patient groups compared with the control group. In addition, mean serum and BAL TGF-ß levels were found to be increased in patients with SP compared with PMF group. Based on these results, BAL and serum cytokine and antioxidant enzymes levels were evaluated and discussed as potential biomarkers for different stages of CWP. © 2008 SAGE Publications.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Antioxidant enzymes
Konu Başlıkları
[dc.subject]
Coal workers' pneumoconiosis
Konu Başlıkları
[dc.subject]
Proinflammatory cytokines
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0960-3271
İlk Sayfa Sayısı
[dc.identifier.startpage]
871
Son Sayfa Sayısı
[dc.identifier.endpage]
877
Dergi Adı
[dc.relation.journal]
Human and Experimental Toxicology
Dergi Sayısı
[dc.identifier.issue]
12
Dergi Cilt Bilgisi
[dc.identifier.volume]
27
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1177/0960327108098332
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7497
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
5
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 06:38
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Tıklayınız
levels compared groups disease pneumoconiosis patients increased IL-1ß enzymes antioxidant stages cytokine higher patient retired active superoxide results Publications different biomarkers potential discussed evaluated dismutase TGF-ß addition control catalase peroxidase glutathione relation investigated divided fibrosis
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