Protective effect of flaxseed oil on renal injury in hyperlipidaemic rats: The effect of flaxseed oil on hyperlipidaemia

This study evaluated the possible effects of flaxseed oil on renal damage associated with hyperlipidaemic rats. Wistar albino male rats were divided into three groups. Group I was fed with a pellet chow. Group II was fed with a high cholesterol diet (HCD) consisting of 5% cholesterol and 0.35% cholic acid added to the pellet chow. Group III was fed with the same HCD, but were orally treated with a dose of 15 mg/kg body wt/day flaxseed oil. Flaxseed oil treatment started 1 week before and continued throughout the 22 weeks of the HCD. At the end of the experiment, renal tissue and blood samples were collected. The biochemical and histopathological findings confirmed renal damage in hypercholesterolaemia conditions. Flaxseed oil reduced the hypercholesterolaemia-induced increase in the serum levels of total cholesterol, LDL and urea. Oil red O stain revealed that lowered serum lipid was accompanied by a decreased deposition of neutral lipid. Flaxseed oil effectively reversed these abnormalities, verifying the protective effects of flaxseed oil in ameliorating renal injuries associated with hypercholesterolaemia. Copyright © 2010 John Wiley & Sons, Ltd.

Yazar Akpolat M.
Kanter M.
Topcu-Tarladacalisir Y.
Aydogdu N.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7231
Tek Biçim Adres 10.1002/ptr.3334
Konu Başlıkları biochemistry
flaxseed oil
hyperlipidaemia
morphology
renal injury
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Phytotherapy Research
Dergi Cilt Bilgisi 25
Dergi Sayısı 6
Sayfalar 796 - 802
Yayın Yılı 2011
Eser Adı
[dc.title]
Protective effect of flaxseed oil on renal injury in hyperlipidaemic rats: The effect of flaxseed oil on hyperlipidaemia
Yazar
[dc.contributor.author]
Akpolat M.
Yazar
[dc.contributor.author]
Kanter M.
Yazar
[dc.contributor.author]
Topcu-Tarladacalisir Y.
Yazar
[dc.contributor.author]
Aydogdu N.
Yayın Yılı
[dc.date.issued]
2011
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
This study evaluated the possible effects of flaxseed oil on renal damage associated with hyperlipidaemic rats. Wistar albino male rats were divided into three groups. Group I was fed with a pellet chow. Group II was fed with a high cholesterol diet (HCD) consisting of 5% cholesterol and 0.35% cholic acid added to the pellet chow. Group III was fed with the same HCD, but were orally treated with a dose of 15 mg/kg body wt/day flaxseed oil. Flaxseed oil treatment started 1 week before and continued throughout the 22 weeks of the HCD. At the end of the experiment, renal tissue and blood samples were collected. The biochemical and histopathological findings confirmed renal damage in hypercholesterolaemia conditions. Flaxseed oil reduced the hypercholesterolaemia-induced increase in the serum levels of total cholesterol, LDL and urea. Oil red O stain revealed that lowered serum lipid was accompanied by a decreased deposition of neutral lipid. Flaxseed oil effectively reversed these abnormalities, verifying the protective effects of flaxseed oil in ameliorating renal injuries associated with hypercholesterolaemia. Copyright © 2010 John Wiley & Sons, Ltd.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
biochemistry
Konu Başlıkları
[dc.subject]
flaxseed oil
Konu Başlıkları
[dc.subject]
hyperlipidaemia
Konu Başlıkları
[dc.subject]
morphology
Konu Başlıkları
[dc.subject]
renal injury
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0951418X
İlk Sayfa Sayısı
[dc.identifier.startpage]
796
Son Sayfa Sayısı
[dc.identifier.endpage]
802
Dergi Adı
[dc.relation.journal]
Phytotherapy Research
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
25
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1002/ptr.3334
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7231
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
10
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
29 Ocak 2024 17:01
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Tıklayınız
flaxseed Flaxseed cholesterol pellet hypercholesterolaemia associated damage effects reduced levels increase hypercholesterolaemia-induced revealed conditions confirmed findings histopathological biochemical reversed ameliorating Copyright injuries protective lowered verifying abnormalities samples effectively neutral deposition decreased accompanied collected cholic consisting
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