Severe childhood amitriptyline intoxication and plasmapheresis: A case report

Tricyclic antidepressant intoxication is one of the most frequently encountered and life-threatening causes of intoxication among referrals to emergency departments due to drug intoxication. There is no known antidote against any of the tricyclic antidepressants. The American Society for Apheresis (ASFA) recommends plasmapheresis to support primary treatment in this type of drug poisoning, which does not respond to certain and traditional treatments. We present a 15-year-old girl who ingested amitriptyline with suicidal intent. On admission, she was in a comatose state (Glasgow Coma Scale score: 5), with no spontaneous respiration and presence of pathological reflexes. Due to the intake history of lethal doses and the severe clinical picture, plasmapheresis was performed. She was discharged on her fifth day of hospitalization. Due to the high plasma protein binding property of amitriptyline, plasma exchange therapy should be considered in cases of severe amitriptyline intoxication as a life-saving therapeutic modality.

Dergi Adı Turkish Journal of Pediatrics
Dergi Cilt Bilgisi 55
Dergi Sayısı 6
Sayfalar 645 - 647
Yayın Yılı 2013
Eser Adı
[dc.title]
Severe childhood amitriptyline intoxication and plasmapheresis: A case report
Yazar
[dc.contributor.author]
Karaci M.
Yazar
[dc.contributor.author]
Özçetin M.
Yazar
[dc.contributor.author]
Dilsiz G.
Yazar
[dc.contributor.author]
Güçlü-Songür Y.G.
Yayın Yılı
[dc.date.issued]
2013
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Tricyclic antidepressant intoxication is one of the most frequently encountered and life-threatening causes of intoxication among referrals to emergency departments due to drug intoxication. There is no known antidote against any of the tricyclic antidepressants. The American Society for Apheresis (ASFA) recommends plasmapheresis to support primary treatment in this type of drug poisoning, which does not respond to certain and traditional treatments. We present a 15-year-old girl who ingested amitriptyline with suicidal intent. On admission, she was in a comatose state (Glasgow Coma Scale score: 5), with no spontaneous respiration and presence of pathological reflexes. Due to the intake history of lethal doses and the severe clinical picture, plasmapheresis was performed. She was discharged on her fifth day of hospitalization. Due to the high plasma protein binding property of amitriptyline, plasma exchange therapy should be considered in cases of severe amitriptyline intoxication as a life-saving therapeutic modality.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Amitriptyline
Konu Başlıkları
[dc.subject]
Childhood
Konu Başlıkları
[dc.subject]
Intoxication
Konu Başlıkları
[dc.subject]
Plasmapheresis
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0041-4301
İlk Sayfa Sayısı
[dc.identifier.startpage]
645
Son Sayfa Sayısı
[dc.identifier.endpage]
647
Dergi Adı
[dc.relation.journal]
Turkish Journal of Pediatrics
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
55
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7510
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
6
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 09:42
Google Kontrol
Tıklayınız
intoxication amitriptyline plasmapheresis severe plasma history intake lethal reflexes pathological Tricyclic presence respiration spontaneous (Glasgow comatose clinical property modality therapeutic life-saving considered should therapy exchange binding picture protein hospitalization admission discharged performed American antidepressants tricyclic
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms