Radiological and stereological evaluation of the effect of rifampin on bone healing in critical-size defects
Objectives: This study aimed to investigate the effect of rifampin with autogenous bone on bone regeneration in critical-size defects in the calvaria of rats. Materials and Methods: In total, 40 rats were divided into 4 groups and a 5-mm diameter of calvarial defect was made in each rat's calvarium. Control group (C), bone defects were irrigated with sterile saline; rifampin group (R), bone defects were irrigated with rifampin. In the autogenous graft group (Ag), the autogenous graft was contaminated with saliva, and the defects were filled with an autogenous graft. In the autogenous graft + rifampin group (Ag+R), the autogenous graft was contaminated with saliva and was decontaminated with rifampin, and the defects were filled with the autogenous graft. The animals were killed at 4weeks. Bone formation was assessed by micro-computed tomography scanning and stereological analyses. Results: The mean new bone volume was the greatest in the Ag/rifampin group (1.73±0.17), followed by the Ag group (1.50±0.05) (statistically significant difference at P<0.05). The new bone volume was the lowest in the control group (1.05±0.09); however, no difference was observed compared with the rifampin group (1.08±0.07) (P>0.05). Conclusion: This study, despite its limitations, showed that rifampin with autogenous bone increased bone regeneration in rats with critical-size defects. © Copyright 2016 by Mutaz B. Habal, MD.
| Yazar |
Durmuşlar M.C. Balli U. Türer A. Önger M.E. Çelik H.H. |
| Yayın Türü | Article |
| Tek Biçim Adres | https://hdl.handle.net/20.500.12628/7297 |
| Tek Biçim Adres | 10.1097/SCS.0000000000002762 |
| Konu Başlıkları |
Bone regeneration
Critical-size defects Rifampin |
| Koleksiyonlar |
Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD Scopus İndeksli Yayınlar Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu |
| Dergi Adı | Journal of Craniofacial Surgery |
| Dergi Cilt Bilgisi | 27 |
| Dergi Sayısı | 6 |
| Sayfalar | 1481 - 1485 |
| Yayın Yılı | 2016 |
| Eser Adı [dc.title] | Radiological and stereological evaluation of the effect of rifampin on bone healing in critical-size defects |
| Yazar [dc.contributor.author] | Durmuşlar M.C. |
| Yazar [dc.contributor.author] | Balli U. |
| Yazar [dc.contributor.author] | Türer A. |
| Yazar [dc.contributor.author] | Önger M.E. |
| Yazar [dc.contributor.author] | Çelik H.H. |
| Yayın Yılı [dc.date.issued] | 2016 |
| Yayıncı [dc.publisher] | Lippincott Williams and Wilkins |
| Yayın Türü [dc.type] | article |
| Özet [dc.description.abstract] | Objectives: This study aimed to investigate the effect of rifampin with autogenous bone on bone regeneration in critical-size defects in the calvaria of rats. Materials and Methods: In total, 40 rats were divided into 4 groups and a 5-mm diameter of calvarial defect was made in each rat's calvarium. Control group (C), bone defects were irrigated with sterile saline; rifampin group (R), bone defects were irrigated with rifampin. In the autogenous graft group (Ag), the autogenous graft was contaminated with saliva, and the defects were filled with an autogenous graft. In the autogenous graft + rifampin group (Ag+R), the autogenous graft was contaminated with saliva and was decontaminated with rifampin, and the defects were filled with the autogenous graft. The animals were killed at 4weeks. Bone formation was assessed by micro-computed tomography scanning and stereological analyses. Results: The mean new bone volume was the greatest in the Ag/rifampin group (1.73±0.17), followed by the Ag group (1.50±0.05) (statistically significant difference at P<0.05). The new bone volume was the lowest in the control group (1.05±0.09); however, no difference was observed compared with the rifampin group (1.08±0.07) (P>0.05). Conclusion: This study, despite its limitations, showed that rifampin with autogenous bone increased bone regeneration in rats with critical-size defects. © Copyright 2016 by Mutaz B. Habal, MD. |
| Kayıt Giriş Tarihi [dc.date.accessioned] | 2019-12-23 |
| Açık Erişim Tarihi [dc.date.available] | 2019-12-23 |
| Yayın Dili [dc.language.iso] | eng |
| Konu Başlıkları [dc.subject] | Bone regeneration |
| Konu Başlıkları [dc.subject] | Critical-size defects |
| Konu Başlıkları [dc.subject] | Rifampin |
| Haklar [dc.rights] | info:eu-repo/semantics/closedAccess |
| ISSN [dc.identifier.issn] | 1049-2275 |
| İlk Sayfa Sayısı [dc.identifier.startpage] | 1481 |
| Son Sayfa Sayısı [dc.identifier.endpage] | 1485 |
| Dergi Adı [dc.relation.journal] | Journal of Craniofacial Surgery |
| Dergi Sayısı [dc.identifier.issue] | 6 |
| Dergi Cilt Bilgisi [dc.identifier.volume] | 27 |
| Tek Biçim Adres [dc.identifier.uri] | https://dx.doi.org/10.1097/SCS.0000000000002762 |
| Tek Biçim Adres [dc.identifier.uri] | https://hdl.handle.net/20.500.12628/7297 |
