Pathogenesis of Crimean–Congo Hemorrhagic Fever From an Immunological Perspective

Crimean–Congo hemorrhagic fever (CCHF) is a severe viral infection disease. Infection is a battle between the virus and host immune system. The CCHF virus can enter to the organism by way of skin, mucosa, or inhalation and encounters innate immune system cells like monocytes, macrophages, and dendritic cells. These cells cannot successfully eliminate viruses. Thus, the viruses are able to disseminate to regional lymph nodes and to whole body. Different viral pathogen-associated molecular patterns (PAMPs) stimulate the intracellular Toll-like receptors, RIG-like Helicase receptors, and NOD-like receptors. So, different inflammatory cytokines, chemokines, and adhesion molecules are induced. The virus has both direct cytopathic effects on parenchymal cells especially on the liver, spleen, and endothelial cells and non-cytopathic indirect effects depending upon releasing factors from innate immune cells. In severe fatal cases, infection causes coagulation by stimulating both intrinsic and extrinsic coagulation pathways and disseminated intravascular coagulopathy occurs. The prognosis of the disease is dependent on the balance between the viral load and host’s immune system. While high values of IL-12/IL-10, IL-15/IL-10, IL-18/IL-10, and IFN-?/IL-10 ratios show strong TH1 immune status, low values show suppressed immune system. These ratios together with viral load can indicate the patients’ clinical prognosis from an immunological perspective. © 2016, Springer International Publishing AG.

Yazar Arasli M.
Yayın Türü Review
Tek Biçim Adres https://hdl.handle.net/20.500.12628/6932
Tek Biçim Adres 10.1007/s40475-016-0068-0
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Sayfalar 14 - 19
Yayın Yılı 2016
Eser Adı
[dc.title]
Pathogenesis of Crimean–Congo Hemorrhagic Fever From an Immunological Perspective
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
Springer Verlag
Yayın Türü
[dc.type]
review
Özet
[dc.description.abstract]
Crimean–Congo hemorrhagic fever (CCHF) is a severe viral infection disease. Infection is a battle between the virus and host immune system. The CCHF virus can enter to the organism by way of skin, mucosa, or inhalation and encounters innate immune system cells like monocytes, macrophages, and dendritic cells. These cells cannot successfully eliminate viruses. Thus, the viruses are able to disseminate to regional lymph nodes and to whole body. Different viral pathogen-associated molecular patterns (PAMPs) stimulate the intracellular Toll-like receptors, RIG-like Helicase receptors, and NOD-like receptors. So, different inflammatory cytokines, chemokines, and adhesion molecules are induced. The virus has both direct cytopathic effects on parenchymal cells especially on the liver, spleen, and endothelial cells and non-cytopathic indirect effects depending upon releasing factors from innate immune cells. In severe fatal cases, infection causes coagulation by stimulating both intrinsic and extrinsic coagulation pathways and disseminated intravascular coagulopathy occurs. The prognosis of the disease is dependent on the balance between the viral load and host’s immune system. While high values of IL-12/IL-10, IL-15/IL-10, IL-18/IL-10, and IFN-?/IL-10 ratios show strong TH1 immune status, low values show suppressed immune system. These ratios together with viral load can indicate the patients’ clinical prognosis from an immunological perspective. © 2016, Springer International Publishing AG.
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s40475-016-0068-0
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6932
Yayın Dili
[dc.language.iso]
eng
Yazar
[dc.contributor.author]
Arasli M.
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
İlk Sayfa Sayısı
[dc.identifier.startpage]
14
Son Sayfa Sayısı
[dc.identifier.endpage]
19
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
9
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
04 Şubat 2024 23:06
Google Kontrol
Tıklayınız
immune system receptors prognosis ratios innate coagulation viruses between severe values infection disease effects occurs intravascular disseminated dependent coagulopathy Crimean–Congo pathways extrinsic intrinsic stimulating causes factors releasing depending indirect balance strong host’s indicate Publishing International
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms